Výsledky vyhledávání - "Hugh Wiltshire"

Pharmacodynamics of Oral Ganciclovir and Valganciclovir in Solid Organ Transplant Recipients

Autor: Atul Humar, Barbara D. Alexander, Nigel Heaton, Emily A. Blumberg, Kenneth Washburn, Edward A. Dominguez, Rene Bouw, Carlos V. Paya, Richard B. Freeman, Hugh Wiltshire, Mark D. Pescovitz, Klaas P. Zuideveld

Publikováno v: Transplantation. 79:1477-1483

Background A randomized, double-blind study was conducted to evaluate the pharmacokinetics of ganciclovir following oral administration of ganciclovir or valganciclovir for prophylaxis of cytomegalovirus (CMV) disease in solid organ transplant recipi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fcfb7d67dcf43b0edfef2ff35ddaa98
https://doi.org/10.1097/01.tp.0000164512.99703.ad

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Modulation of Oral Squamous Cell Carcinoma Incidence in Rats Via Diet and a Novel Calcium Channel Antagonist

Autor: David A. Eichler, Bernhard Schläppi, John Wood, Flavio Crameri, Robin A. Seymour, Barbara Lenz, Hugh Wiltshire

Publikováno v: Toxicologic Pathology. 33:356-364

An unexpected dose related increase in oral squamous cell carcinomas was observed in a standard 2-year carcinogenicity study with a novel calcium channel blocker, in which Wistar rats received daily doses of 0, 1.5, 7, 20, or 40 mg/kg of the compound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef8dc63259f326fd8ca135e6dee09c23
https://doi.org/10.1080/01926230590930119

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Pharmacokinetic Profile of Ganciclovir After its Oral Administration and From its Prodrug, Valganciclovir, in Solid Organ Transplant Recipients

Autor: Mark D. Pescovitz, Hugh Wiltshire, Barbara D. Alexander, Carlos V. Paya, Richard B. Freeman, Colm Farrell, Emily A. Blumberg, Kenneth Washburn, Edward A. Dominguez, Nigel Heaton, Sarapee Hirankarn, Atul Humar

Publikováno v: Clinical Pharmacokinetics. 44:495-507

Valganciclovir (Valcyte) has recently been approved for the prevention of cytomegalovirus (CMV) disease in high-risk (CMV donor positive [D+]/recipient negative [R-]) solid organ transplant (SOT) recipients. Large-scale studies describing the pharmac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a6106a7576eb1af4cced20bec69e3e8
https://doi.org/10.2165/00003088-200544050-00003

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Factors Responsible for the Variability of Saquinavir Absorption: Studies Using an Instrumented Dog Model

Autor: Soheir Tawfik, Yun K. Tam, Hugh Wiltshire, Nuzhat Tam-Zaman

Publikováno v: Pharmaceutical Research. 21:436-442

To study the effect of dose and food on the bioavailability of saquinavir in dogs.A Youden Square block design was used for six female mongrel dogs (20-24 kg) who received six saquinavir treatments. The six randomized treatments were 1 mg/kg intraven

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127e90aad1fcc78e3223fb79b0348587
https://doi.org/10.1023/b:pham.0000019296.47762.3f

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Development of a high-performance liquid chromatographic–mass spectrometric assay for the specific and sensitive quantification of Ro 64-0802, an anti-influenza drug, and its pro-drug, oseltamivir, in human and animal plasma and urine

Autor: Carolyn Serpe, Andrea Citron, Hugh Wiltshire, Tony Clarke, Donald Gray, William Herron, Barbara Wiltshire

Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 745:373-388

Oseltamivir phosphate (Ro 64-0796/002) is a pro-drug of the anti-influenza neuraminidase inhibitor, Ro 64-0802, and as Tamiflu, has been developed for the treatment of both A and B strains of the disease. This paper describes an HPLC-MS-MS assay for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18cab5504f5e9a8848febbf9ea341c9c
https://doi.org/10.1016/s0378-4347(00)00300-5

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thy/liv‐SCID‐hu Mice: A System for Investigating the In Vivo Effects of Multidrug Therapy on Plasma Viremia and Human Immunodeficiency Virus Replication in Lymphoid Tissues

Autor: Christina Raker, Massimo Pettoello-Mantovani, Tobias R. Kollmann, Sergey Yurasov, Hugh Wiltshire, Harris Goldstein, Ana Kim, Nikos F. Katopodis

Publikováno v: The Journal of Infectious Diseases. 177:337-346

Modified, human immunodeficiency virus (HIV)-inoculated thy/liv-SCID-hu mice were used to evaluate the in vivo efficacy of antiretroviral drugs. Ritonavir treatment alone initially suppressed plasma viremia, but the viremia recurred with the appearan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9c249c066fe8dfdee8a836deb44918
https://doi.org/10.1086/514214

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Clinical Pharmacokinetics of Mibefradil

Autor: Roy Bullingham, Hugh Wiltshire, Horst A. Welker

Publikováno v: Clinical Pharmacokinetics. 35:405-423

Mibefradil, a tetralol derivative, is a new long-acting calcium antagonist used for the treatment of patients with hypertension and chronic stable angina pectoris. The drug is virtually completely metabolised, with less than 3% of an oral dose excret

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d90d9e97d04df58ce9a3365eea36b9a5
https://doi.org/10.2165/00003088-199835060-00001

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A placebo- and midazolam-controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of remimazolam (CNS 7056): Part II. Population pharmacokinetic and pharmacodynamic modeling and simulation

Autor: Keith M. Borkett, Gavin J. Kilpatrick, Gary Stuart Tilbrook, Hugh Wiltshire

Publikováno v: Anesthesia and analgesia. 115(2)

A new benzodiazepine, remimazolam, which is rapidly metabolized by tissue esterases to an inactive metabolite, has been developed to permit a fast onset, a short, predictable duration of sedative action, and a more rapid recovery profile than current

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00459b7f721476c262e30c8eb4e3f8bc
https://pubmed.ncbi.nlm.nih.gov/23788743

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