Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Hugh Walton"'
Autor:
Vanessa Martins, Lynsey Fazal, Aram Oganesian, Alpesh Shah, Jessie Stow, Hugh Walton, Nicola Wilsher
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 52(8)
Paxlovid, a drug combining nirmatrelvir and ritonavir, was designed for the treatment of COVID-19 and its rapid development has led to emergency use approval by the FDA to reduce the impact of COVID-19 infection on patients.In order to overcome poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee4ca0ff271dad1caf94488e5d4c9327
https://pubmed.ncbi.nlm.nih.gov/36537234
https://pubmed.ncbi.nlm.nih.gov/36537234
Autor:
Michael Reader, Aurélie Courtin, Steven Howard, Nicola G. Wallis, Jonathan Shannon, Hugh Walton, Christopher William Murray, Joseph E. Coyle, Joanne M. Munck, Alison Jo-Anne Woolford, Torren M. Peakman, David C. Rees, James Edward Harvey Day, Charlotte Mary Griffiths-Jones, Marc O'Reilly, Alpesh Shah, David Norton, Valerio Berdini, Lynsey Fazal, Maria Grazia Carr, Charlotte East, Tom D. Heightman, Nicola E. Wilsher, Ildiko Maria Buck, Luke Bevan, Stuart Thomas Onions, Michael Cooke, Justyna Kucia-Tran, Sandra Muench, Nick Palmer, Sharna J. Rich, Vanessa Martins, David Cousin, Puja Pathuri, John P. Watts
Publikováno v:
Journal of medicinal chemistry. 64(16)
Aberrant activation of the mitogen-activated protein kinase pathway frequently drives tumor growth, and the ERK1/2 kinases are positioned at a key node in this pathway, making them important targets for therapeutic intervention. Recently, a number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d0e8543148c5c72af0eca510047c9f
https://pubmed.ncbi.nlm.nih.gov/34387469
https://pubmed.ncbi.nlm.nih.gov/34387469
Autor:
Neil T. Thompson, Charlotte Mary Griffiths-Jones, John Lyons, Vanessa Martins, Nicola E. Wilsher, Tom D. Heightman, Harpreet K Saini, Juan Castro, Stuart Thomas Onions, David Cousin, Nicola G. Wallis, Valerio Berdini, Nick Palmer, Puja Pathuri, Caroline Richardson, Christopher William Murray, Charlotte East, John P. Watts, Marc O'Reilly, Sharna J. Rich, Hugh Walton, James Edward Harvey Day, Aurélie Courtin, Brent Graham, David C. Rees, Hannah Braithwaite, Michael Cooke, Ildiko Maria Buck, Michael Reader, Sandra Muench, Megan Cassidy, Jonathan Shannon, Joanne M. Munck, Alison Jo-Anne Woolford, David Norton, Lynsey Fazal
Publikováno v:
Journal of Medicinal Chemistry. 61:4978-4992
Aberrant activation of the MAPK pathway drives cell proliferation in multiple cancers. Inhibitors of BRAF and MEK kinases are approved for the treatment of BRAF mutant melanoma, but resistance frequently emerges, often mediated by increased signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64bcd2385197c9e1b7f9532e4d26523
https://doi.org/10.1021/acs.jmedchem.8b00421
https://doi.org/10.1021/acs.jmedchem.8b00421
Autor:
S Wedge, Roger J. Griffin, Maria Ahn, Karen Haggerty, Juan Castro, Ian R. Hardcastle, Celine Cano, Christopher N. Johnson, Bernard T. Golding, Herbie Newell, Steven Howard, Luke Bevan, Timothy J. Blackburn, Pamela A. Williams, Martin E.M. Noble, Yan Zhao, Judith Reeks, Ruth H. Bawn, Neil Thompson, Emiliano Tamanini, Ben Cons, Huw Thomas, Lynsey Fazal, Hugh Walton, Elaine Willmore, Sarah J. Cully, Gianni Chessari, Keisha Hearn, Ildiko Maria Buck
Publikováno v:
Cancer Research. 78:1652-1652
In response to cellular stress, the p53 tumor suppressor is activated to modulate cell cycle progression, DNA repair, and cell death. The activity of p53 is tightly regulated by MDM2, an E3 ubiquitin ligase that targets p53 for proteasomal degradatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f11828bba8837e5bc77a00d94f5218f
https://doi.org/10.1158/1538-7445.am2018-1652
https://doi.org/10.1158/1538-7445.am2018-1652
Autor:
Nicola G. Wallis, Nick Palmer, Tom D. Heightman, Mike Reader, Sharna J. Rich, Hannah Braithwaite, Hugh Walton, James Edward Harvey Day, Valerio Berdini, Sandra Muench, Christopher W. Murray, Nicola E. Wilsher, Brent Graham, Neil Thompson, Harpreet K Saini, Charlotte Mary Griffiths-Jones, Caroline Richardson, Juan Castro, Vanessa Martins, Aurélie Courtin, Puja Pathuri, Marc O'Reilly, Charlotte East, David C. Rees, Joanne M. Munck, Alison Jo-Anne Woolford, David Norton, Lynsey Fazal, Ildiko Maria Buck, John Lyons, Megan Cassidy
Publikováno v:
Molecular Cancer Therapeutics. 17:B161-B161
The RAS-RAF-MEK-ERK signalling cascade is activated through mutations in RAS or RAF in over 30% of cancers. The successful development of inhibitors of BRAF and MEK kinases has led to effective treatment particularly of melanomas whose tumor growth i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c708bbf81913113391a623dbb8c78ef
https://doi.org/10.1158/1535-7163.targ-17-b161
https://doi.org/10.1158/1535-7163.targ-17-b161
Autor:
Luke Bevan, John Lyons, Caroline Richardson, Charlotte Mary Griffiths-Jones, Juan Castro, Lukas Stanczuk, Alpesh Shah, Hugh Walton, Neil T. Thompson, Harpreet K Saini, Nicola G. Wallis, Joanne M. Munck, Alison Jo-Anne Woolford, David Norton, Tom D. Heightman, Lynsey Fazal, Christopher J. Hindley, Christopher W. Murray, Hannah Braithwaite, Mike Reader, Vanessa Martins, Charlotte East, Puja Pathuri, Birikiti Kidane, Marc O'Reilly, David C. Rees, Aurélie Courtin, Megan Cassidy, Justyna Kucia-Tran, James Edward Harvey Day, Sandra Muench, Nicola E. Wilsher, Ildiko Maria Buck, Nick Palmer, Sharna J. Rich, Valerio Berdini, Brent Graham
Publikováno v:
Molecular Cancer Therapeutics. 17:B154-B154
The MAPK pathway is commonly hyper-activated in human cancers due to the occurrence of oncogenic mutations in RAF, RAS and the upregulation of RTKs. The therapeutic potential of MAPK pathway inhibition has been demonstrated by the clinical efficacy o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fb0f164a64005dde16a1115a0571fd2
https://doi.org/10.1158/1535-7163.targ-17-b154
https://doi.org/10.1158/1535-7163.targ-17-b154
