Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Hugh R.B. Pelham"'
Autor:
Arthur Abelian, Carol Charan, Amanda Ogilvy-Stuart, Thomas Mund, Martin D. Curran, Paul H. Dear, Nipa Mitra, Stuart A. Savill, Hugh R.B. Pelham
Publikováno v:
BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-11 (2020)
BMC Infectious Diseases
BMC Infectious Diseases
BackgroundPCRctic is an innovative assay based on 16S rDNA PCR technology that has been designed to detect a single intact bacterium in a specimen of cerebro-spinal fluid (CSF). The assay’s potential for accurate, fast and inexpensive discriminatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f20005f8a75918a5e4f8d3b76189ac8
http://link.springer.com/article/10.1186/s12879-020-05160-x
http://link.springer.com/article/10.1186/s12879-020-05160-x
Autor:
Mariann Bienz, Gonzalo J Beitia, Stefan M.V. Freund, Melissa V. Gammons, Hugh R.B. Pelham, Trevor J. Rutherford
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance We report a Dishevelled structural clamp, a β-sheet containing a conserved phosphorylation site immediately upstream of the Dishevelled, Egl-10, and Pleckstrin (DEP) domain, contacting a cognate surface on its partner DEP domain to stab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ef07ee4a12b9b6a992501e1aa33667
https://doi.org/10.1073/pnas.2103258118
https://doi.org/10.1073/pnas.2103258118
Autor:
Hugh R.B. Pelham, Thomas Mund
Publikováno v:
The Journal of Biological Chemistry
The Nedd4 family of HECT domain–containing E3 ligases ubiquitinate many transcription factors and signaling proteins, and their activity is tightly regulated. Normally, intramolecular interactions curb the catalytic activity of the HECT domain, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7207378eacf054d16f549f3f4ec816
https://doi.org/10.1074/jbc.ra117.000934
https://doi.org/10.1074/jbc.ra117.000934
Autor:
Amanda Ogilvy-Stuart, N Mitra, A Abelian, M Curran, Thomas Mund, Hugh R.B. Pelham, C Charan, PH Dear
Publikováno v:
British Association of Perinatal Medicine.
Aims An assay based on 16S rDNA PCR technology has been designed to detect a single intact bacterium whilst eliminating free DNA from dead bacteria, thus offering unprecedented sensitivity and scope to the analysis of bacterial carriage in clinical s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d587f3a8e37fde5d013c6b4a622c790
https://doi.org/10.1136/archdischild-2018-rcpch.200
https://doi.org/10.1136/archdischild-2018-rcpch.200
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200763 (2018)
PLoS ONE
PLoS ONE
Alpha-synuclein can form beta-sheet filaments, the accumulation of which plays a key role in the development of Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. It has previously been shown that alpha-synuclein is a substra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c152fd4b3898cd9f5e89ab86b0afe55
http://europepmc.org/articles/PMC6051637?pdf=render
http://europepmc.org/articles/PMC6051637?pdf=render
Autor:
Elina Nikko, Hugh R.B. Pelham
Publikováno v:
Traffic (Copenhagen, Denmark)
Many plasma membrane transporters in yeast are endocytosed in response to excess substrate or certain stresses and degraded in the vacuole. Endocytosis invariably requires ubiquitination by the HECT domain ligase Rsp5. In the cases of the manganese t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f954f998b17e6a6e90974bcf5232da42
http://europepmc.org/articles/PMC2810449
http://europepmc.org/articles/PMC2810449
Autor:
Mariann Bienz, Michael Graeb, Juliusz Mieszczanek, Hugh R.B. Pelham, Thomas Mund, Melissa V. Gammons
Publikováno v:
Open Biology
Open Biology, Vol 5, Iss 12 (2015)
Open Biology, Vol 5, Iss 12 (2015)
Dishevelled is a pivot in Wnt signal transduction, controlling both β-catenin-dependent transcription to specify proliferative cell fates, and cell polarity and other non-nuclear events in post-mitotic cells. In response to Wnt signals, or when pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf73c487303e2482236a7492eb1a9f5
http://europepmc.org/articles/PMC4703060
http://europepmc.org/articles/PMC4703060
Autor:
Hugh R.B. Pelham
Publikováno v:
Trends in Biochemical Sciences. 31:601-604
Newly synthesized secretory proteins pass through the Golgi apparatus, which consists of multiple cisternae containing distinct populations of enzymes. Are the cargo proteins shuttled between cisternae in vesicles or do they remain in a cisterna whil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3bf7eb8f255ed0cb9456919ed2ed5b8
https://doi.org/10.1016/j.tibs.2006.09.002
https://doi.org/10.1016/j.tibs.2006.09.002
Publikováno v:
The EMBO Journal. 25:662-672
Plasma membrane transporters are often downregulated by their substrates. The yeast manganese transporter Smf1 is subject to two levels of regulation: heavy metals induce its sequestration within the cell, and also its ubiquitination and degradation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4edeca70dd8afc91846987738a331c6
https://doi.org/10.1038/sj.emboj.7600984
https://doi.org/10.1038/sj.emboj.7600984
Publikováno v:
Traffic. 7:182-190
Membrane fusion in cells involves the interaction of SNARE proteins on apposing membranes. Formation of SNARE complexes is preceded by tethering events, and a number of protein complexes that are thought to mediate this have been identified. The VFT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5243f88f4985c745da35f4afa949c25
https://doi.org/10.1111/j.1600-0854.2005.00374.x
https://doi.org/10.1111/j.1600-0854.2005.00374.x