Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Hugh P.J. Bennett"'
Autor:
Hugh P.J. Bennett, Sarah Duhaime, Celine Vrancx, James J Doyle, Claudia Maios, Babykumari P Chitramuthu, J. Alex Parker, Andrew Bateman
Publikováno v:
Proc Natl Acad Sci U S A
In 2006, GRN mutations were first linked to frontotemporal dementia (FTD), the leading cause of non-Alzheimer dementias. While much research has been dedicated to understanding the genetic causes of the disease, our understanding of the mechanistic i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0981699ed71579745f4b221d15f4c3b5
https://doi.org/10.1073/pnas.2022115118
https://doi.org/10.1073/pnas.2022115118
Publikováno v:
Brain. 140:3081-3104
Progranulin, a secreted glycoprotein, is encoded in humans by the single GRN gene. Progranulin consists of seven and a half, tandemly repeated, non-identical copies of the 12 cysteine granulin motif. Many cellular processes and diseases are associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8fcbc4bde4ba007db9ee15674c3029a
https://doi.org/10.1093/brain/awx198
https://doi.org/10.1093/brain/awx198
Publikováno v:
Methods in Molecular Biology ISBN: 9781493985579
Progranulin is composed of seven repeating cysteine-rich granulin domains. In some cells and tissues, the progranulin is fragmented by proteolysis to generate the granulin modules as individual peptides, which are collectively referred to as granulin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9715a095949096a46968b72a80860335
https://doi.org/10.1007/978-1-4939-8559-3_2
https://doi.org/10.1007/978-1-4939-8559-3_2
Publikováno v:
Methods in Molecular Biology ISBN: 9781493985579
The purpose of this brief overview of the progranulin protein is to provide a sense of the range and extent of the roles of progranulin in normal physiology and pathology. Progranulin has received attention due to its role in neurodegeneration, where
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::643033d9965d771e9dd5a5d6836d8f13
https://doi.org/10.1007/978-1-4939-8559-3_1
https://doi.org/10.1007/978-1-4939-8559-3_1
Publikováno v:
Methods in Molecular Biology ISBN: 9781493985579
The zebrafish (Danio rerio), a small tropical fish, has become a powerful model for the study of early vertebrate development, human diseases, and drug screening. Zebrafish provides large numbers of optically clear embryos, and its development is ver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94f7924de9a36ba0d06248961c8f2c43
https://doi.org/10.1007/978-1-4939-8559-3_15
https://doi.org/10.1007/978-1-4939-8559-3_15
Autor:
Nabil G. Seidah, Babykumari P Chitramuthu, Hugh P.J. Bennett, Benoît Cadieux, David C. Baranowski, Estelle Rousselet
Publikováno v:
Developmental Dynamics. 239:2933-2946
Pro-protein convertase subtilisin/kexin 5 (PC5, also known as PC6) is a member of the subtilisin-like superfamily of serine proteases implicated in the maturation of latent precursor proteins into their functionally active derivatives. To investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f42900684f6b0b0eb4aa92b014374b6a
https://doi.org/10.1002/dvdy.22426
https://doi.org/10.1002/dvdy.22426
Publikováno v:
The Journal of Endocrinology
Lys-gamma3-MSH is a melanocortin peptide derived from the C-terminal of the 16 kDa fragment of POMC. The physiological role of Lys-gamma3-MSH is unclear, although it has previously been shown that, although not directly steroidogenic, it can act to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec74293105d94ce0c7ad2c7d9305cc6
http://europepmc.org/articles/PMC2216415
http://europepmc.org/articles/PMC2216415
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 47:14-24
Carp granulins are members of an emerging class of proteins with a sequence motif encoding a parallel stack of two to four β-hairpins. The carp granulin-1 protein forms a stack of four β-hairpins, whereas its amino-terminal fragment appears to adop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9072ad25042f3a5c31674e48ca6c3479
https://doi.org/10.1002/prot.10077
https://doi.org/10.1002/prot.10077
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 3, p e0174784 (2017)
PLoS ONE, Vol 12, Iss 3, p e0174784 (2017)
Progranulin (PGRN) is a glycoprotein with multiple roles in normal and disease states. Mutations within the GRN gene cause frontotemporal lobar degeneration (FTLD). The affected neurons display distinctive TAR DNA binding protein 43 (TDP-43) inclusio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8f9076cad26b2bea23e0d3b34b1955
https://doi.org/10.1371/journal.pone.0174784
https://doi.org/10.1371/journal.pone.0174784
Publikováno v:
Environmental Science & Technology. 33:3812-3820
Batch soil washing experiments were performed to evaluate the feasibility of using surfactin from Bacillus subtilis, a lipopeptide biosurfactant, for the removal of heavy metals from a contaminated soil and sediments. The soil contained high levels o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d82e2bcc2059f5431960d2feefff3fd
https://doi.org/10.1021/es9813055
https://doi.org/10.1021/es9813055