Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Hugh P. C. Robinson"'
Autor:
Hugh P. C. Robinson, Leanne Li
Publikováno v:
Open Biology, Vol 7, Iss 12 (2017)
N-Methyl-d-aspartate receptor (NMDAR) activation is implicated in the malignant progression of many cancer types, as previously shown by the growth-inhibitory effects of NMDAR antagonists. NMDAR-mediated calcium influx and its downstream signalling d
Externí odkaz:
https://doaj.org/article/c695b50c85244517b40cc60882798448
Autor:
Michael eVella, Robert C. Cannon, Sharon eCrook, Andrew P. Davison, Gautham eGanapathy, Hugh P. C. Robinson, R. Angus Silver, Padraig eGleeson
Publikováno v:
Frontiers in Neuroinformatics, Vol 8 (2014)
NeuroML is an XML-based model description language, which provides a powerful common data format for defining and exchanging models of neurons and neuronal networks. In the latest version of NeuroML, the structure and behavior of ion channel, synapse
Externí odkaz:
https://doaj.org/article/2eb9cca98712448f953ab85192b2e134
Autor:
Hugh P. C. Robinson, Victoria Kyle, Philipe R. F. Mendonça, Shel-Hwa Yeo, William H. Colledge
Publikováno v:
The Journal of Physiology. 596:885-899
Key points Neurons in the hypothalamus of the brain which secrete the peptide kisspeptin are important regulators of reproduction, and normal reproductive development. Electrical activity, in the form of action potentials, or spikes, leads to secreti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74861628ef81bc72a54fbff4e9e86dce
https://doi.org/10.1113/jp274474
https://doi.org/10.1113/jp274474
Publikováno v:
Biophysical Journal. 113:2383-2395
Fluctuation analysis is a method that allows measurement of the single-channel current of ion channels even when it is too small to be resolved directly with the patch-clamp technique. This is the case for voltage-gated calcium channels. They are pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::084772fcfe512a60536f7197fdf2ce4f
https://doi.org/10.1016/j.bpj.2017.09.025
https://doi.org/10.1016/j.bpj.2017.09.025
Autor:
Brian D. McCabe, Douglas Hanahan, Graham Knott, Qiqun Zeng, Sadegh Saghafinia, Giovanni Ciriello, Peng Zhang, Inti Zlobec, Hugh P. C. Robinson, Wei Jiao, José A. Galván, Iacovos P. Michael
Publikováno v:
Nature, vol. 573, no. 7775, pp. 526-531
Nature
Nature
Summary Metastasis - the disseminated growth of tumours in distant organs – underlies cancer mortality. Breast-to-brain metastasis (B2BM) is disconcertingly common and disruptive, being prevalent in the aggressive basal-like subtype, albeit evident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19da7ac88268bc4a40f18131aa355b84
https://serval.unil.ch/notice/serval:BIB_7FA9C67632A4
https://serval.unil.ch/notice/serval:BIB_7FA9C67632A4
Autor:
Michael Dannemann, Hugo Zeberg, Victor Wiebe, Wulf Hevers, Kristin Tsuo, Tomislav Maricic, Hugh P. C. Robinson, Kristoffer Sahlholm, Svante Pääbo, Janet Kelso
Publikováno v:
Current Biology
The sodium channel Nav1.7 is crucial for impulse generation and conduction in peripheral pain pathways [1]. In Neanderthals, the Nav1.7 protein carried three amino acid substitutions (M932L, V991L, and D1908G) relative to modern humans. We expressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c5745afdc4658bf1bcf4e41adb7686
https://doi.org/10.1016/j.cub.2020.06.045
https://doi.org/10.1016/j.cub.2020.06.045
Autor:
Ole Paulsen, Hugh P. C. Robinson, Ferenc Erdélyi, Philipe R. F. Mendonça, Gábor Szabó, Mariana Vargas-Caballero
Publikováno v:
eLife
eLife, Vol 5 (2016)
eLife, Vol 5 (2016)
Most cortical neurons fire regularly when excited by a constant stimulus. In contrast, irregular-spiking (IS) interneurons are remarkable for the intrinsic variability of their spike timing, which can synchronize amongst IS cells via specific gap jun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad7a36762ad539da4eeb98feb87e105c
Publikováno v:
Journal of Neurophysiology. 109:2739-2756
The distal apical dendrites of layer 5 pyramidal neurons receive cortico-cortical and thalamocortical top-down and feedback inputs, as well as local recurrent inputs. A prominent source of recurrent inhibition in the neocortical circuit is somatostat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee51ca64119764d9f5f308015565638
https://doi.org/10.1152/jn.00397.2012
https://doi.org/10.1152/jn.00397.2012
Publikováno v:
Biophysical journal. 113(11)
Fluctuation analysis is a method that allows measurement of the single-channel current of ion channels even when it is too small to be resolved directly with the patch-clamp technique. This is the case for voltage-gated calcium channels. They are pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d41867e7916e746f3bd3e574ec9e58fc
https://pubmed.ncbi.nlm.nih.gov/29211992
https://pubmed.ncbi.nlm.nih.gov/29211992
Autor:
Terrence J. Sejnowski, William A. Catterall, Ole Paulsen, Hugh P. C. Robinson, Indira M. Raman
Publikováno v:
The Journal of Neuroscience. 32:14064-14073
The Hodgkin-Huxley studies of the action potential, published 60 years ago, are a central pillar of modern neuroscience research, ranging from molecular investigations of the structural basis of ion channel function to the computational implications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa00119da7ef373ec00616f55bf432bd
https://doi.org/10.1523/jneurosci.3403-12.2012
https://doi.org/10.1523/jneurosci.3403-12.2012