Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Hugh P Cam"'
Publikováno v:
eLife, Vol 3 (2014)
Histone modifiers play essential roles in controlling transcription and organizing eukaryotic genomes into functional domains. Here, we show that Set1, the catalytic subunit of the highly conserved Set1C/COMPASS complex responsible for histone H3K4 m
Externí odkaz:
https://doaj.org/article/bf67120172524e3684873b94d9e8fffd
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004740 (2014)
Histone modifiers are critical regulators of chromatin-based processes in eukaryotes. The histone methyltransferase Set1, a component of the Set1C/COMPASS complex, catalyzes the methylation at lysine 4 of histone H3 (H3K4me), a hallmark of euchromati
Externí odkaz:
https://doaj.org/article/100c79cfcb8f4027a40d21bafacf16ea
Publikováno v:
PLoS Genetics, Vol 3, Iss 8, p e141 (2007)
Meiotic recombination is initiated by DNA double-strand breaks (DSBs) made by Spo11 (Rec12 in fission yeast), which becomes covalently linked to the DSB ends. Like recombination events, DSBs occur at hotspots in the genome, but the genetic factors re
Externí odkaz:
https://doaj.org/article/b49598dd440744499602cd1523a1bde3
Autor:
Nagendran Ramalingam, Shan-Xue Jin, Tim E. Moors, Luis Fonseca-Ornelas, Kazuma Shimanaka, Shi Lei, Hugh P. Cam, Aurelia Hays Watson, Lisa Brontesi, Lai Ding, Dinc Yasat Hacibaloglu, Haiyang Jiang, Se Joon Choi, Ellen Kanter, Lei Liu, Tim Bartels, Silke Nuber, David Sulzer, Eugene V. Mosharov, Weisheng V. Chen, Shaomin Li, Dennis J. Selkoe, Ulf Dettmer
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract In Parkinson’s disease and other synucleinopathies, the elevation of α-synuclein phosphorylated at Serine129 (pS129) is a widely cited marker of pathology. However, the physiological role for pS129 has remained undefined. Here we use mult
Externí odkaz:
https://doaj.org/article/d183b6fc70b54d8f9e89896f83034181
Autor:
Ping-Chieh Pao, Debasis Patnaik, L. Ashley Watson, Fan Gao, Ling Pan, Jun Wang, Chinnakkaruppan Adaikkan, Jay Penney, Hugh P. Cam, Wen-Chin Huang, Lorena Pantano, Audrey Lee, Alexi Nott, Trongha X. Phan, Elizabeta Gjoneska, Sara Elmsaouri, Stephen J. Haggarty, Li-Huei Tsai
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Defects in DNA repair have been linked to brain aging and neurodegenerative disorders. Here the authors reveal a role for HDAC1 in stimulating OGG1 activity to alleviate 8-oxoG lesions with implications in the aging brain and neurodegenerative diseas
Externí odkaz:
https://doaj.org/article/31affdab15104a389accac5fde35981f
Autor:
Joel W. Blanchard, Leyla Anne Akay, Jose Davila-Velderrain, Djuna von Maydell, Hansruedi Mathys, Shawn M. Davidson, Audrey Effenberger, Chih-Yu Chen, Kristal Maner-Smith, Ihab Hajjar, Eric A. Ortlund, Michael Bula, Emre Agbas, Ayesha Ng, Xueqiao Jiang, Martin Kahn, Cristina Blanco-Duque, Nicolas Lavoie, Liwang Liu, Ricardo Reyes, Yuan-Ta Lin, Tak Ko, Lea R’Bibo, William T. Ralvenius, David A. Bennett, Hugh P. Cam, Manolis Kellis, Li-Huei Tsai
Publikováno v:
Nature
APOE4 is the strongest genetic risk factor for Alzheimer’s disease (AD)(1–3). Yet, the effects of APOE4 on the human brain are not fully understood, limiting opportunities to develop targeted therapeutics for APOE4 and other AD risk factors(4–8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df54e657d5fe7daad7baaff25c0f9d13
https://europepmc.org/articles/PMC9870060/
https://europepmc.org/articles/PMC9870060/
Autor:
Yuan-Ta Lin, Alexander Frank, Li-Huei Tsai, Joel W. Blanchard, Michael Bula, Matheus B. Victor, Hansruedi Mathys, Jose Davila-Velderrain, Lena Zhu, Manolis Kellis, Julia Maeve Bonner, Tak Ko, Leyla Anne Akay, Hugh P. Cam, David A. Bennett
Publikováno v:
Nat Med
In Alzheimer's disease, amyloid deposits along the brain vasculature lead to a condition known as cerebral amyloid angiopathy (CAA), which impairs blood-brain barrier (BBB) function and accelerates cognitive degeneration. Apolipoprotein (APOE4) is th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796c6e72f10ca2eb5e7400e54801203f
https://doi.org/10.1038/s41591-020-0886-4
https://doi.org/10.1038/s41591-020-0886-4
Autor:
Leyla Anne Akay, Fatema Abdurrob, Li-Huei Tsai, Maggie Chen, Wen-Chin Huang, Jay Penney, Lorena Pantano Rubino, William T. Ralvenius, Zhuyu Peng, Xiao Chen, Hugh P. Cam
Cyclin dependent kinase 5 (Cdk5) regulates various developmental and physiological processes in the central nervous system. Deregulation of Cdk5 activity in neurons induces severe neurodegeneration and has been implicated in Alzheimer’s disease (AD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c18e44f37dde0631c3bbcda6ca3dc03
https://doi.org/10.1101/2020.05.12.090605
https://doi.org/10.1101/2020.05.12.090605
Autor:
Peter Johansen, Hugh P. Cam
Publikováno v:
Genetics. 201:897-904
Meiotic homologous recombination (HR) is not uniform across eukaryotic genomes, creating regions of HR hot- and coldspots. Previous study reveals that the Spo11 homolog Rec12 responsible for initiation of meiotic double-strand breaks in the fission y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44675b0a6e0abef4089c0eb29195a9b6
https://doi.org/10.1534/genetics.115.179465
https://doi.org/10.1534/genetics.115.179465
Autor:
Hugh P. Cam, Simon K. Whitehall
Publikováno v:
Cold Spring Harbor protocols. 2016(11)
Digestion of chromatin with micrococcal nuclease (MNase) is widely used to probe nucleosome organization. Analysis of MNase digests by end-labeling techniques or overlapping quantitative polymerase chain reaction (qPCR) can be used to map locus-speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464689982ce0e9fb45bb34a3d160ca63
https://pubmed.ncbi.nlm.nih.gov/27803256
https://pubmed.ncbi.nlm.nih.gov/27803256