Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Hugh McDade"'
Autor:
R.H. Kauffmann, N.A. Foudraine, F. De Wolf, C M Schuwirth, S. A. Danner, Jaap Goudsmit, John M. Leonard, Pieter L. Meenhorst, Suzanne Jurriaans, C. Goodwin, J J de Jong, Hugh McDade, Daan W. Notermans, Winston Cavert
Publikováno v:
AIDS, 12(2), 167-173. Lippincott Williams and Wilkins
Notermans, D W, Jurriaans, S, De Wolf, F, Foudraine, N A, De Jong, J J, Cavert, W, Schuwirth, C M, Kauffmann, R H, Meenhorst, P L, McDade, H, Goodwin, C, Leonard, J M, Goudsmit, J & Danner, S A 1998, ' Decrease of HIV-1 RNA levels in lymphoid tissue and peripheral blood during treatment with ritonavir, lamivudine and zidovudine ', AIDS, vol. 12, no. 2, pp. 167-173 . https://doi.org/10.1097/00002030-199802000-00006
Notermans, D W, Jurriaans, S, De Wolf, F, Foudraine, N A, De Jong, J J, Cavert, W, Schuwirth, C M, Kauffmann, R H, Meenhorst, P L, McDade, H, Goodwin, C, Leonard, J M, Goudsmit, J & Danner, S A 1998, ' Decrease of HIV-1 RNA levels in lymphoid tissue and peripheral blood during treatment with ritonavir, lamivudine and zidovudine ', AIDS, vol. 12, no. 2, pp. 167-173 . https://doi.org/10.1097/00002030-199802000-00006
Objectives: Triple combination treatment of HIV-1 infection using two reverse transcriptase inhibitors and a protease inhibitor can result in significant and sustained decreases in the quantity of viral RNA in peripheral blood. Lymphoid tissue, howev
Autor:
John Bartlett, Christine Katlama, Schlomo Staszewski, Hugh McDade, Judy Johnson, Andrew M. Hill, W. Sawyer, Joseph J. Eron
Publikováno v:
AIDS. 11:477-483
Objectives: Four randomized double-blind trials have demonstrated that zidovudine/lamivudine (ZDV/3TC) reduces HIV RNA and raises CD4 counts relative to control treatments [ZDV or ZDV/zalcitabine (ddC)]. A meta-analysis of the clinical events in thes
Autor:
Martin A. Nowak, Andrew M. Hill, Hugh McDade, Richard Boehme, Sebastian Bonhoeffer, Howard C. Thomas
Publikováno v:
Proceedings of the National Academy of Sciences. 93:4398-4402
Treatment of chronic hepatitis B virus (HBV) infections with the reverse transcriptase inhibitor lamivudine leads to a rapid decline in plasma viremia and provides estimates for crucial kinetic constants of HBV replication. We find that in persistent
Autor:
Valerie Kitchen, Hugh McDade, Remko van Leeuwen, Andrew M. Hill, Roland Tubiana, Didier Ingrand, Sven A. Danner, Jonathan Weber, Michael McBride, Charles A. Boucher, Christine Katlama
Publikováno v:
Journal of Infectious Diseases, 171(5), 1166-1171. Oxford University Press
Van Leeuwen, R, Katlama, C, Kitchen, V, Boucher, C A B, Tubiana, R, Mc Bride, M, Ingrand, D, Weber, J, Hill, A, Mc Dade, H & Danner, S A 1995, ' Evaluation of safety and efficacy of 3tc (lamivudine) in patients with asymptomatic or mildly symptomatic human immunodeficiency virus infection : A phase i/ii study ', Journal of Infectious Diseases, vol. 171, no. 5, pp. 1166-1171 . https://doi.org/10.1093/infdis/171.5.1166
Van Leeuwen, R, Katlama, C, Kitchen, V, Boucher, C A B, Tubiana, R, Mc Bride, M, Ingrand, D, Weber, J, Hill, A, Mc Dade, H & Danner, S A 1995, ' Evaluation of safety and efficacy of 3tc (lamivudine) in patients with asymptomatic or mildly symptomatic human immunodeficiency virus infection : A phase i/ii study ', Journal of Infectious Diseases, vol. 171, no. 5, pp. 1166-1171 . https://doi.org/10.1093/infdis/171.5.1166
In a phase 1/11 study, 7 levelsof3TC therapy (from 0.5 to 20.0 mg/kg/day) were studied in 104 asymptomatic and mildly symptomatic human immunodeficiency virus-infected patients with CD4 cell counts Ȧ4400 × 106/L. Mild and transient episodes of diar
Autor:
Jan Andersson, Anders Sönnerborg, Hugh McDade, Brian Gazzard, Hans-Jürgen Stellbrink, Li-Ean Goh, Christina Broström, Rainer Weber, Laura A. Napolitano, Karin Loré, Luc Perrin, Yvette van Kooyk
Publikováno v:
AIDS, 16(5), 683-92. Lippincott Williams and Wilkins
Loré, K, Sönnerborg, A, Broström, C, Goh, L-E, Perrin, L, McDade, H, Stellbrink, H-J, Gazzard, B, Weber, R, Napolitano, L A, van Kooyk, Y & Andersson, J 2002, ' Accumulation of DC-SIGN+CD40+ dendritic cells with reduced CD80 and CD86 expression in lymphoid tissue during acute HIV-1 infection ', AIDS, vol. 16, no. 5, pp. 683-92 .
Loré, K, Sönnerborg, A, Broström, C, Goh, L-E, Perrin, L, McDade, H, Stellbrink, H-J, Gazzard, B, Weber, R, Napolitano, L A, van Kooyk, Y & Andersson, J 2002, ' Accumulation of DC-SIGN+CD40+ dendritic cells with reduced CD80 and CD86 expression in lymphoid tissue during acute HIV-1 infection ', AIDS, vol. 16, no. 5, pp. 683-92 .
BACKGROUND: Dendritic cells (DC) are target cells for HIV-1 and play a key role in antigen presentation and activation of T cells.OBJECTIVE: To characterize interdigitating DC in lymphoid tissue (LT) with regard to maturation, expression of cytokines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be3cd37cefa48af35fb0590435d60e3
https://research.vumc.nl/en/publications/e5bdb187-6a24-4852-b11b-15441b0c0ffc
https://research.vumc.nl/en/publications/e5bdb187-6a24-4852-b11b-15441b0c0ffc
Autor:
Hugh McDade, Hans Jürgen Stellbrink, Sabine Kinloch, Luc Perrin, David A. Cooper, Anna-Lena Spetz, Jakob Nilsson, Jan Andersson, Thomas E. Fehniger, Homira Behbahani, Brian Gazzard, Anders Sönnerborg, Li-Ean Goh
Publikováno v:
The Journal of infectious diseases. 185(9)
Human immunodeficiency virus (HIV)‐s pecific cytotoxic T lymphocyte (CTL) responses are detectable shortly after the acute phase of HIV infection, but they cannot control viral replication and prevent development of chronic immune suppression. This
Autor:
Adriano Lazzarin, Giuseppe Tambussi, Cecilia Graziosi, Jean-Marc Corpataux, Giuseppe Pantaleo, Pascal Meylan, G. Paolo Rizzardi, Miguel Munoz, Jean Philippe Chave, Hugh McDade, Luc Perrin, Nermin Halkic, Jean-Yves Meuwly, Sabine Yerly, William Spreen, A. Chapuis, Pierre-Alexandre Bart
Publikováno v:
AIDS, vol. 14, no. 13, pp. 1887-1897
OBJECTIVE: To evaluate the immunological and virological responses to highly active antiretroviral therapy (HAART) in blood and lymphoid compartments of HIV-1-infected patients at an early stage of infection. DESIGN: An open-label, observational, non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f367f366287e501e47e27dd20650e7
https://serval.unil.ch/notice/serval:BIB_93716372A45C
https://serval.unil.ch/notice/serval:BIB_93716372A45C
Autor:
Stephen W. Wietgrefe, Marc K. Jenkins, Carolyn Goodwin, Winston Cavert, Ashley T. Haase, Keith Henry, Zong-ming Chen, Gerald Sedgewick, Kristin Gebhard, Lawrence R. Boies, Roger Mills, Daan W. Notermans, Zhiqiang Zhang, Sven A. Danner, Mary Zupancic, Hugh McDade, Caspar M. Schuwirth
Publikováno v:
Zhang, Z Q, Notermans, D W, Sedgewick, G, Cavert, W, Wietgrefe, S, Zupancic, M, Gebhard, K, Henry, K, Boies, L, Chen, Z, Jenkins, M, Mills, R, Mcdade, H, Goodwin, C, Schuwirth, C M, Danner, S A & Haase, A T 1998, ' Kinetics of CD4+ T cell repopulation of lymphoid tissues after treatment of HIV-1 infection ', Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 3, pp. 1154-1159 . https://doi.org/10.1073/pnas.95.3.1154
Proceedings of the National Academy of Sciences of the United States of America, 95(3), 1154-1159. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 95(3), 1154-1159. National Academy of Sciences
Potent combinations of antiretroviral drugs diminish the turnover of CD4+ T lymphocytes productively infected with HIV-1 and reduce the large pool of virions deposited in lymphoid tissue (LT). To determine to what extent suppression of viral replicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a31d6a424a4868ec498a379b5df4241
https://europepmc.org/articles/PMC18704/
https://europepmc.org/articles/PMC18704/
Autor:
Luc Perrin, Andrew N. Phillips, Chris Tsoukas, David A. Cooper, Anders Sönnerborg, Sabine Kinloch, Hugh McDade, Brigitte Autran, Li-Ean Goh, Bruno Hoen
Publikováno v:
Nature Medicine. 6:1194-1194
Autor:
Clive Loveday, Peter Skinhøj, Lucy Verity, Pierre Dellamonica, P. Richard Harrigan, Schlomo Staszewski, Juan J. Picazo, Hugh McDade, Sven A. Danner, Andrew M. Hill, Margaret A. Johnson
Publikováno v:
Staszewski, S, Loveday, C, Picazo, J J, Dellamonica, P, Skinhøj, P, Johnson, M A, Danner, S A, Harrigan, P R, Hill, A M, Verity, L & McDade, H 1996, ' Safety and efficacy of lamivudine-zidovudine combination therapy in zidovudine-experienced patients : A randomized controlled comparison with zidovudine monotherapy ', Journal of the American Medical Association, vol. 276, no. 2, pp. 111-117 . https://doi.org/10.1001/jama.276.2.111
Journal of the American Medical Association, 276(2), 111-117. American Medical Association
Journal of the American Medical Association, 276(2), 111-117. American Medical Association
Objective. - To compare the safety and efficacy of 2 doses of lamivudine given in combination with zidovudine with continued zidovudine monotherapy. Design. - Double-blind, randomized, multicenter, comparative trial of 223 patients treated for 24 wee