BRCA1-IRIS overexpression promotes formation of aggressive breast cancers.

Autor: Yoshiko Shimizu, Hugh Luk, David Horio, Penelope Miron, Michael Griswold, Dirk Iglehart, Brenda Hernandez, Jeffrey Killeen, Wael M ElShamy

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e34102 (2012)

INTRODUCTION: Women with HER2(+) or triple negative/basal-like (TN/BL) breast cancers succumb to their cancer rapidly due, in part to acquired Herceptin resistance and lack of TN/BL-targeted therapies. BRCA1-IRIS is a recently discovered, 1399 residu

Externí odkaz: https://doaj.org/article/3225956a554e477f82956337ce290c00

Clinical and pathological associations of PTEN expression in ovarian cancer: a multicentre study from the Ovarian Tumour Tissue Analysis Consortium

Autor: Scott H. Kaufmann, Daniel Guimarães Tiezzi, Valerie Rhenius, Gary L. Keeney, Alexander Hein, Dominique-Laurent Couturier, Florin Andrei Taran, Robert Edwards, Aline Talhouk, Stacey J. Winham, Christiani Bisinoto de Sousa, Nadja Pejovic, Andreas D. Hartkopf, Ramona Erber, Brenda Y. Hernandez, Jenny Lester, Teri A. Longacre, Anna L. Paterson, Peter Sinn, Robin Crawford, Lene Lundvall, Hugh Luk, Roberta B. Ness, Adekunle Odunsi, Suha Deen, Javier Benitez, Alice S. Whittemore, Anna Fischer, Anthony N. Karnezis, Christine Chow, Ana Osorio, Ellen L. Goode, Stefan Kommoss, Angela Brooks-Wilson, Linda E. Kelemen, Tanja Pejovic, Simon A. Gayther, Peter A. Fasching, Beth Y. Karlan, Jurandyr Moreira de Andrade, Samuel Leung, David D.L. Bowtell, James D. Brenton, Aleksandra Vrvilo, Marc T. Goodman, Paul D.P. Pharoah, Sara Y. Brucker, Honglin Song, Jennifer M Koziak, Robert A. Vierkant, Naveena Singh, Valerie McGuire, Chloe Karpinskyj, Mercedes Jimenez-Linan, Aleksandra Gentry-Maharaj, Anna deFazio, Jenny Chang-Claude, Linda S. Cook, Francesmary Modugno, Filipe C. Martins, Estrid Høgdall, Prafull Ghatage, Marie Lyne Alcaraz, Susan J. Ramus, Annette Staebler, Jennifer Alsop, David G. Huntsman, Joseph H. Rothstein, Tayyebeh M. Nazeran, Cristina Rodríguez-Antona, Luis Robles-Díaz, Bryan M. McCauley, María Jesús Gómez García, Michael E. Carney, Michael S. Anglesio, Yurii B. Shvetsov, Claus Høgdall, Sian Fereday, Martin Köbel, Maria P. Intermaggio, Sandra Orsulic, Luis Paz-Ares, Mary Anne Brett, Weiva Sieh, Matthias W. Beckmann, Helen Steed, Arndt Hartmann, Michael Schneider, Lynne R. Wilkens, Esther Herpel, Jacek Gronwald, Francisco José Candido dos Reis, Nhu D. Le, Gregg Nelson, Kirsten B. Moysich, Nadia Traficante, Usha Menon

Publikováno v: British journal of cancer, vol 123, iss 5
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Martins, F C, Couturier, D, Paterson, A, Karnezis, A N, Chow, C, Nazeran, T M, Odunsi, A, Gentry-maharaj, A, Vrvilo, A, Hein, A, Talhouk, A, Osorio, A, Hartkopf, A D, Brooks-wilson, A, Defazio, A, Fischer, A, Hartmann, A, Hernandez, B Y, Mccauley, B M, Karpinskyj, C, De Sousa, C B, Høgdall, C, Tiezzi, D G, Herpel, E, Taran, F A, Modugno, F, Keeney, G, Nelson, G, Steed, H, Song, H, Luk, H, Benitez, J, Alsop, J, Koziak, J M, Lester, J, Rothstein, J H, De Andrade, J M, Lundvall, L, Paz-ares, L, Robles-díaz, L, Wilkens, L R, Garcia, M J, Intermaggio, M P, Alcaraz, M, Brett, M A, Beckmann, M W, Jimenez-linan, M, Anglesio, M, Carney, M E, Schneider, M, Traficante, N, Pejovic, N, Singh, N, Le, N, Sinn, P, Ghatage, P, Erber, R, Edwards, R, Vierkant, R, Ness, R B, Leung, S, Orsulic, S, Brucker, S Y, Kaufmann, S H, Fereday, S, Gayther, S, Winham, S J, Kommoss, S, Pejovic, T, Longacre, T A, Mcguire, V, Rhenius, V, Sieh, W, Shvetsov, Y B, Whittemore, A S, Staebler, A, Karlan, B Y, Rodriguez-antona, C, Bowtell, D D, Goode, E L, Høgdall, E, Candido Dos Reis, F J, Gronwald, J, Chang-claude, J, Moysich, K B, Kelemen, L E, Cook, L S, Goodman, M T, Fasching, P A, Crawford, R, Deen, S, Menon, U, Huntsman, D G, Köbel, M, Ramus, S J, Pharoah, P D P & Brenton, J D 2020, ' Clinical and pathological associations of PTEN expression in ovarian cancer : a multicentre study from the Ovarian Tumour Tissue Analysis Consortium ', British Journal of Cancer, vol. 123, no. 5, pp. 793-802 . https://doi.org/10.1038/s41416-020-0900-0
British Journal of Cancer

Background PTEN loss is a putative driver in histotypes of ovarian cancer (high-grade serous (HGSOC), endometrioid (ENOC), clear cell (CCOC), mucinous (MOC), low-grade serous (LGSOC)). We aimed to characterise PTEN expression as a biomarker in epithe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13264fefe2a6be09d6a938187ba510f0

High Incidence of Somatic BAP1 Alterations in Sporadic Malignant Mesothelioma

Autor: Harvey I. Pass, Michele Carbone, Sandra Pastorino, Francine Baumann, Michael J. Becich, Mika Tanji, Adi F. Gazdar, Amy Powers, Giovanni Gaudino, Hugh Luk, Maarit Tiirikainen, Shreya Kanodia, Erin G. Flores, Mitsuru Emi, Haining Yang, Masaki Nasu, Yu An Zhang

Publikováno v: Journal of Thoracic Oncology. 10:565-576

Background Breast cancer 1-associated protein 1 (BAP1) is a nuclear deubiquitinase that regulates gene expression, transcription, DNA repair, and more. Several findings underscore the apparent driver role of BAP1 in malignant mesothelioma (MM). Howev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b802d8a5e2eafccd5640d20749342e65
https://doi.org/10.1097/jto.0000000000000471

Geminin overexpression induces mammary tumors via suppressing cytokinesis

Autor: Jeffrey Killeen, Brenda Hernandez, Rohit Malik, David Horio, Nicole Mullins, Zannel Blanchard, Hugh Luk, Wael M. ElShamy, Christine Maric

Publikováno v: Oncotarget
Scopus-Elsevier

Zannel Blanchard * , Rohit Malik * , Nicole Mullins, Christine Maric, Hugh Luk, David Horio, Brenda Hernandez, Jeffrey Killeen and Wael M. ElShamy 1 Cancer Institute and Department of Biochemistry, University of Mississippi Medical Center, 2500 N. St

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9811d4918a873379603d1f9f17150f1
http://europepmc.org/articles/PMC3282064

Abstract 3944: High incidence of somatic BAP1 alterations in sporadic malignant mesothelioma

Autor: Erin G. Flores, Michele Carbone, Haining Yang, Masaki Nasu, Giovanni Gaudino, Shreya Kanodia, Hugh Luk, Amy Powers, Adi F. Gazdar, Sandra Pastorino, Mitsuru Emi, Yuan Zhang, Harvey I. Pass, Francine Baumann

Publikováno v: Cancer Research. 75:3944-3944

Background: Malignant mesothelioma (MM) is a lethal tumor whose pathogenesis results from complex interactions between host genetics and environmental carcinogens. BAP1 mutations were reported in 22% and 23% of sporadic MM in two US Caucasian studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70c0fe3d7bf55e81cff691238b9446c8
https://doi.org/10.1158/1538-7445.am2015-3944