Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Hugh L.J. Makin"'
Publikováno v:
Journal of Bone and Mineral Research. 22:V11-V15
Plasma 25(OH)D has emerged as a valuable biomarker for the many varied health-related effects of vitamin D in the clinic mainly because of the recognition of the importance of the enzyme, CYP27B1, or the 25(OH)D-alpha-hydroxylase in the extrarenal, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ebf03ad641a94f1eab26c4f2c82f14
https://doi.org/10.1359/jbmr.07s219
https://doi.org/10.1359/jbmr.07s219
Publikováno v:
Collection of Czechoslovak Chemical Communications. 67:1-9
Cortisol and cortisone are the two main glucocorticoids found in human plasma. Cortisol is commonly measured as a means of assessing adrenal function, usually by immunoassay, but such procedures must be subject to proper quality control which ideally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfe4e4f99a0bbdbad18b812256d4b0ec
https://doi.org/10.1135/cccc20020001
https://doi.org/10.1135/cccc20020001
Autor:
E. Barbara Mawer, Glenville Jones, Valarie Byford, Michael Davies, Joyce C. Knutson, Neil J. Schroeder, Pamela E. Still, Hugh L.J. Makin, Charles W. Bishop
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 83:2156-2166
We have produced evidence for a new metabolic pathway for vitamin D2 in humans involving the production of 24-hydroxyvitamin D2 (24OHD2) and 1,24-dihydroxyvitamin D2 [1,24-(OH)2D2]. These metabolites were produced after either a single large dose (10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7d4cb95f7c6f3e585d7a50419adb09d
https://doi.org/10.1210/jcem.83.6.4841
https://doi.org/10.1210/jcem.83.6.4841
Autor:
Ernst Torndal Binderup, Christina Mørk Hansen, Glenville Jones, Lise Binderup, V.Narayanaswamy Shankar, Neil J. Schroeder, Niels Smidt Rastrup Andersen, Anne-Marie Kissmeyer, Hugh L.J. Makin
Publikováno v:
Biochemical Pharmacology. 53:1087-1097
l(S),3(R)-dihydroxy-20(R)-(5′-ethyl-5′-hydroxy-hepta-l′(E),3′(E)-dien-l′-yl)-9,10-secopregna-5(Z),7(E),10(19)-triene (EB 1089) is a novel analog of the vitamin D hormone, calcitriol that has been modified in the side-chain resulting in an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57064e4eef13550be2b28c7cfca67e8c
https://doi.org/10.1016/s0006-2952(96)00816-7
https://doi.org/10.1016/s0006-2952(96)00816-7
Autor:
Ernst Torndal Binderup, Anne-marie Kissmeyer, Hugh L.J. Makin, F. Jeffrey Dilworth, V.Narayanaswamy Shankar, D.J.H. Trafford, Martin John Calverley, Neil J. Schroeder, Glenville Jones
Publikováno v:
Biochemical Pharmacology. 53:783-793
1(S),3(R)-dihydroxy-20(R)-(5'-ethyl-5'-hydroxy-hepta-1'(E),3' (E)-dien-1'-yl)-9,10-secopregna-5(Z),7(E),10(19)-triene (EB1089) is a novel synthetic analog of 1 alpha,25-dihydroxyvitamin D [1,25-(OH)2D3] with potential for use in the treatment of hype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::331909e760342f04b1aa371f049e490c
https://doi.org/10.1016/s0006-2952(96)00815-5
https://doi.org/10.1016/s0006-2952(96)00815-5
Autor:
Glenville Jones, Joyce C. Knutson, Hugh L.J. Makin, Charles W. Bishop, Robert H. Rice, Lea Ann deGraffenried, Richard Kremer, Valarie Byford
Publikováno v:
Biochemical Pharmacology. 52:133-140
Vitamin D analogs represent valuable new agents for the suppression of proliferation of a variety of cell types, including those of the skin. One such analog is the vitamin D 2 metabolite, 1 α ,24( S )-dihydroxyvitamin D 2 , which binds strongly to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c3c15c987ff402304102f200e29063
https://doi.org/10.1016/0006-2952(96)00173-6
https://doi.org/10.1016/0006-2952(96)00173-6
Autor:
J C Knutson, R M Moriarty, C W Bishop, L W LeVan, Stephen Strugnell, R Gilardi, Glenville Jones, Valarie Byford, Hugh L.J. Makin
Publikováno v:
Biochemical Journal. 310:233-241
A major metabolite of the vitamin D analogue 1 alpha-hydroxyvitamin D2 in human liver cells in culture has been identified as 1 alpha,24(S)-dihydroxyvitamin D2 [1 alpha,24(S)-(OH)2D2]. 1 alpha-Hydroxyvitamin D3 incubated with the same cells gives ris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d1a1c507633ef1bff1156a416969255
https://doi.org/10.1042/bj3100233
https://doi.org/10.1042/bj3100233
Publikováno v:
Journal of Mass Spectrometry. 30:348-356
A mass fragmentographic method for the measurement in plasma of underivatized, dehydrated 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 was developed. Quantitative dehydration of vitamin D metabolites was achieved prior to gas chromatography using a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc37cbd026c68df73fb5d37e1d39f47b
https://doi.org/10.1002/jms.1190300218
https://doi.org/10.1002/jms.1190300218
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 78:1481-1487
It has recently been shown that in the rat, dihydrotachysterol (DHT) is extensively metabolized in the side-chain in vivo along pathways similar to those of vitamin D. In addition 25-hydroxy-DHT2 [25OHDHT2] is hydroxylated at C1, producing both 1 alp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7338a78888c1a175258f012a68fb63a7
https://doi.org/10.1210/jcem.78.6.8200953
https://doi.org/10.1210/jcem.78.6.8200953
Publikováno v:
Biochemical Pharmacology. 47:987-993
The 20-epi series of vitamin D 3 analogs has been shown to be made up of more potent inducers of cell differentiation than calcitriol in vitro . Using 20-epi-1α,25-dihydroxyvitamin D 3 (MC 1288), we attempted to rationalize this increased biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bec2d31011d64379e05e228c7fe402e
https://doi.org/10.1016/0006-2952(94)90409-x
https://doi.org/10.1016/0006-2952(94)90409-x