Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Hugh I. Smith"'
Autor:
Matthew G. Iadanza, Robert Silvers, Joshua Boardman, Hugh I. Smith, Theodoros K. Karamanos, Galia T. Debelouchina, Yongchao Su, Robert G. Griffin, Neil A. Ranson, Sheena E. Radford
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Impaired kidney function can lead to an increase of β2-microglobulin (β2m) serum levels, which can cause β2m aggregation and amyloid fibril formation. Here the authors combine cryo-EM and magic angle spinning NMR measurements to determine the stru
Externí odkaz:
https://doaj.org/article/c2131f4762074ff88b7f948f11bb5fd7
Autor:
Emma E. Cawood, Nicolas Guthertz, Hugh I. Smith, Roberto Maya-Martinez, Sheena E. Radford, Alexander L. Breeze
The D76N variant of human β2-microglobulin (β2m) is the causative agent of a hereditary amyloid disease. Interestingly, D76N-associated amyloidosis has a distinctive pathology compared with aggregation of wild-type (WT) β2m which occurs in dialysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe3eebaaf547831e5070cc0272ce70a
https://eprints.whiterose.ac.uk/163223/13/jbc.RA120.014901.full.pdf
https://eprints.whiterose.ac.uk/163223/13/jbc.RA120.014901.full.pdf
Autor:
Ciaran P A, Doherty, Lydia M, Young, Theodoros K, Karamanos, Hugh I, Smith, Matthew P, Jackson, Sheena E, Radford, David J, Brockwell
Publikováno v:
Protein Science : A Publication of the Protein Society
Protein aggregation is linked with the onset of several neurodegenerative disorders, including Parkinson's disease (PD), which is associated with the aggregation of α‐synuclein (αSyn). The structural mechanistic details of protein aggregation, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c5078c90957310d4b04dcfca450fa8cc
https://pubmed.ncbi.nlm.nih.gov/29417650
https://pubmed.ncbi.nlm.nih.gov/29417650