Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Hugh H. Reid"'
Autor:
Tiing Jen Loh, Jia Jia Lim, Claerwen M. Jones, Hien Thy Dao, Mai T. Tran, Daniel G. Baker, Nicole L. La Gruta, Hugh H. Reid, Jamie Rossjohn
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract CD4+ T cells recognising citrullinated self-epitopes presented by HLA-DRB1 bearing the shared susceptibility epitope (SE) are implicated in rheumatoid arthritis (RA). However, the underlying T cell receptor (TCR) determinants of epitope spec
Externí odkaz:
https://doaj.org/article/da55e0bd7eb74b1a926c2737875550c7
Autor:
Amee Sonigra, Hendrik J. Nel, Pascale Wehr, Nishta Ramnoruth, Swati Patel, Karin A. van Schie, Maxwell W. Bladen, Ahmed M. Mehdi, Joanne Tesiram, Meghna Talekar, Jamie Rossjohn, Hugh H. Reid, Frederik E. Stuurman, Helen Roberts, Phillip Vecchio, Ian Gourley, Mark Rigby, Stephane Becart, Rene E.M. Toes, Hans Ulrich Scherer, Kim-Anh Lê Cao, Kim Campbell, Ranjeny Thomas
Publikováno v:
JCI Insight, Vol 7, Iss 20 (2022)
BACKGROUND Antigen-specific regulation of autoimmune disease is a major goal. In seropositive rheumatoid arthritis (RA), T cell help to autoreactive B cells matures the citrullinated (Cit) antigen-specific immune response, generating RA-specific V do
Externí odkaz:
https://doaj.org/article/25d3db325866461e8778f8d46b427806
Autor:
Mai T. Tran, Pouya Faridi, Jia Jia Lim, Yi Tian Ting, Goodluck Onwukwe, Pushpak Bhattacharjee, Claerwen M. Jones, Eleonora Tresoldi, Fergus J. Cameron, Nicole L. La Gruta, Anthony W. Purcell, Stuart I. Mannering, Jamie Rossjohn, Hugh H. Reid
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Epitopes formed by fusion of more than one self peptide, such as proinsulin and other β cell proteins, can result in the formation of non-self hybrid peptides that can potentially trigger autoimmune responses. Here the authors show how TRBV5 + T cel
Externí odkaz:
https://doaj.org/article/6cfc61766a5b4c9d973ece4ad2e9ab57
Autor:
Joshua D. Ooi, Jhih-Hang Jiang, Peter J. Eggenhuizen, Ling L. Chua, Mirjan van Timmeren, Khai L. Loh, Kim M. O’Sullivan, Poh Y. Gan, Yong Zhong, Kirill Tsyganov, Lani R. Shochet, Jessica Ryan, Coen A. Stegeman, Lars Fugger, Hugh H. Reid, Jamie Rossjohn, Peter Heeringa, Stephen R. Holdsworth, Anton Y. Peleg, A. Richard Kitching
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Autoreactivity to myeloperoxidase (MPO) causes autoimmune vasculitis and severe glomerulonephritis. Here, Ooi et al. show that a Staphylococcus aureus plasmid encodes a peptide that is homologous to an immunodominant MPO epitope and induces anti-MPO
Externí odkaz:
https://doaj.org/article/ec5422e66a47466790d6d136a48ebe74
Autor:
Diahann T. S. L. Jansen, Nishta Ramnoruth, Khai L. Loh, Jamie Rossjohn, Hugh H. Reid, Hendrik J. Nel, Ranjeny Thomas
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
With the advent of novel strategies to induce tolerance in autoimmune and autoimmune-like conditions, clinical trials of antigen-specific tolerizing immunotherapy have become a reality. Besides safety, it will be essential to gather mechanistic data
Externí odkaz:
https://doaj.org/article/24fb871f208c46acb03afd4bcca98903
Autor:
Sebastian Klobuch, Jia Jia Lim, Peter van Balen, Michel G. D. Kester, Wendy de Klerk, Arnoud H. de Ru, Cilia R. Pothast, Inge Jedema, Jan W. Drijfhout, Jamie Rossjohn, Hugh H. Reid, Peter A. van Veelen, J. H. Frederik Falkenburg, Mirjam H. M. Heemskerk
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Human leukocyte antigen (HLA) molecules present small peptide antigens to T cells, thereby allowing them to recognize pathogen-infected and cancer cells. A central dogma over the last 50+ y is that peptide binding to HLA molecules is mediated by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924e586f0f2d4628d906859c2fc0f9c1
https://doi.org/10.1073/pnas.2214331119
https://doi.org/10.1073/pnas.2214331119
Autor:
Goodluck Onwukwe, Mai T. Tran, Jamie Rossjohn, Jia Jia Lim, Eleonora Tresoldi, Nicole L. La Gruta, Claerwen M. Jones, Pouya Faridi, Pushpak Bhattacharjee, Anthony W. Purcell, Fergus J. Cameron, Hugh H. Reid, Yi Tian Ting, Stuart I. Mannering
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
HLA-DQ8, a genetic risk factor in type I diabetes (T1D), presents hybrid insulin peptides (HIPs) to autoreactive CD4+ T cells. The abundance of spliced peptides binding to HLA-DQ8 and how they are subsequently recognised by the autoreactive T cell re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60d011244d03b6c452fee4a14906f90
https://doaj.org/article/6cfc61766a5b4c9d973ece4ad2e9ab57
https://doaj.org/article/6cfc61766a5b4c9d973ece4ad2e9ab57
Autor:
Jan Petersen, Hugh H. Reid, Laura Ciacchi, Melinda Y Hardy, Frits Koning, Robert P. Anderson, Khai Lee Loh, Yvonne Kooy-Winkelaar, Jason A. Tye-Din, Anthony W. Purcell, Zhenjun Chen, Jamie Rossjohn, James McCluskey, Mai T. Tran, Nathan P. Croft
Publikováno v:
Nature Structural and Molecular Biology. NATURE PUBLISHING GROUP
Nature Structural and Molecular Biology
Nature Structural and Molecular Biology
Structural, biochemical and cellular analyses show that bacterial antigens can mimic gliadin epitopes involved in celiac disease being presented by HLA-DQ2.5 and recognized by T cells derived from patients.The human leukocyte antigen (HLA) locus is s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abfd599d8b19bafaf0dfa39cb73754c
https://doi.org/10.1038/s41594-019-0353-4
https://doi.org/10.1038/s41594-019-0353-4
Autor:
Laura Ciacchi, Carine Farenc, Shiva Dahal-Koirala, Jan Petersen, Ludvig M. Sollid, Hugh H. Reid, Jamie Rossjohn
Publikováno v:
The Journal of biological chemistry. 298(3)
Celiac disease is a T cell-mediated chronic inflammatory condition often characterized by human leukocyte antigen (HLA)-DQ2.5 molecules presenting gluten epitopes derived from wheat, barley, and rye. Although some T cells exhibit cross-reactivity tow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c333062e87c5ea0d31dd068f855a1b5
https://pubmed.ncbi.nlm.nih.gov/35065967
https://pubmed.ncbi.nlm.nih.gov/35065967
Autor:
Ling Ling Chua, Peter Heeringa, Kirill Tsyganov, Mirjan M. van Timmeren, Coen A. Stegeman, Yong Zhong, Joshua D. Ooi, Hugh H. Reid, Jamie Rossjohn, A. Richard Kitching, Jhih-Hang Jiang, Poh Y. Gan, Lani Shochet, Stephen R. Holdsworth, Jessica Ryan, Peter J. Eggenhuizen, Kim M. O’Sullivan, Lars Fugger, Khai Lee Loh, Anton Y. Peleg
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, 10(1):3392. Nature Publishing Group
Nature Communications
Ooi, J D, Jiang, J-H, Eggenhuizen, P J, Chua, L L, van Timmeren, M, Loh, K L, O'Sullivan, K M, Gan, P Y, Zhong, Y, Tsyganov, K, Shochet, L R, Ryan, J, Stegeman, C A, Fugger, L, Reid, H H, Rossjohn, J, Heeringa, P, Holdsworth, S R, Peleg, A Y & Kitching, A R 2019, ' A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity ', Nature Communications, vol. 10, no. 1, pp. 3392 . https://doi.org/10.1038/s41467-019-11255-0
Nature Communications, 10(1):3392. Nature Publishing Group
Nature Communications
Ooi, J D, Jiang, J-H, Eggenhuizen, P J, Chua, L L, van Timmeren, M, Loh, K L, O'Sullivan, K M, Gan, P Y, Zhong, Y, Tsyganov, K, Shochet, L R, Ryan, J, Stegeman, C A, Fugger, L, Reid, H H, Rossjohn, J, Heeringa, P, Holdsworth, S R, Peleg, A Y & Kitching, A R 2019, ' A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity ', Nature Communications, vol. 10, no. 1, pp. 3392 . https://doi.org/10.1038/s41467-019-11255-0
Autoreactivity to myeloperoxidase (MPO) causes anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), with rapidly progressive glomerulonephritis. Here, we show that a Staphylococcus aureus peptide, homologous to an immunodominant M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4a62d2d45fd6ad2b22f862b3837244
http://link.springer.com/article/10.1038/s41467-019-11255-0
http://link.springer.com/article/10.1038/s41467-019-11255-0