Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Hugh H. Harris"'
Autor:
Kelvin K. H. Tong, Muhammad Hanif, James H. Lovett, Katja Hummitzsch, Hugh H. Harris, Tilo Söhnel, Stephen M. F. Jamieson, Christian G. Hartinger
Publikováno v:
Molecules, Vol 25, Iss 16, p 3661 (2020)
Thiones have been investigated as ligands in metal complexes with catalytic and biological activity. We report the synthesis, characterization, and biological evaluation of a series of MII/III complexes of the general formulae [MII(cym)(L)Cl]X (cym =
Externí odkaz:
https://doaj.org/article/166377e9d24f47daa7cd997320496ee8
Autor:
Katja Hummitzsch, Jasmine E Kelly, Nicholas Hatzirodos, Wendy M Bonner, Feng Tang, Hugh H Harris, Raymond J Rodgers
Publikováno v:
Reproduction and Fertility, Vol 5, Iss 3, Pp 1-12 (2024)
Reactive oxygen species (ROS) are a by-product of the activity of cytochrome P450 steroidogenic enzymes. Antioxidant enzymes protect against ROS damage. To identify if any particular antioxidant enzyme is used to protect against ROS produced by granu
Externí odkaz:
https://doaj.org/article/57796d5751d943d08ee38df287471b6d
Autor:
Katherine Pinto Irish, Maggie-Anne Harvey, Hugh H. Harris, Mark G. M. Aarts, Cheong Xin Chan, Peter D. Erskine, Antony van der Ent
Publikováno v:
Planta, 257(1)
Planta 257 (2023) 1
Planta 257 (2023) 1
Main conclusion Micro-analytical techniques to untangle Se distribution and chemical speciation in plants coupled with molecular biology analysis enable the deciphering of metabolic pathways responsible for Se tolerance and accumulation. Abstract Sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::603a746b3641e60c14d1030588453e77
https://research.wur.nl/en/publications/micro-analytical-and-molecular-approaches-for-understanding-the-d
https://research.wur.nl/en/publications/micro-analytical-and-molecular-approaches-for-understanding-the-d
Autor:
Christian G. Hartinger, Sanam Movassaghi, Kelvin K. H. Tong, James H. Lovett, Suresh K. Bhargava, Katja Hummitzsch, Hugh H. Harris, Stephen M. F. Jamieson, Muhammad Hanif, Tilo Söhnel, Matthew P. Sullivan
Publikováno v:
ChemMedChem. 16:3017-3026
We report investigations on the anticancer activity of organometallic [MII/III (η6 -p-cymene/η5 -pentamethylcyclopentadienyl)] (M=Ru, Os, Rh, and Ir) complexes of N-heterocyclic carbenes (NHCs) substituted with a triazolyl moiety. Depending on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92287425c2f49b8edfb89e2e02d7fd3d
https://doi.org/10.1002/cmdc.202100311
https://doi.org/10.1002/cmdc.202100311
Autor:
Kelly L. Summers, Graham Roseman, Kevin M. Schilling, Natalia V. Dolgova, M. Jake Pushie, Dimosthenis Sokaras, Thomas Kroll, Hugh H. Harris, Glenn L. Millhauser, Ingrid J. Pickering, Graham N. George
Publikováno v:
Inorg Chem
Although Alzheimer’s disease (AD) was first described over a century ago, it remains the leading cause of age-related dementia. Innumerable changes have been linked to the pathology of AD; however, there remains much discord regarding which might b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055469210add149db9276610ef37d92c
https://europepmc.org/articles/PMC9957665/
https://europepmc.org/articles/PMC9957665/
Autor:
Raijeli Taga, Hugh H. Harris, Jack C. Ng, Trang Huynh, Jiajia Zheng, Barry Noller, V. Diacomanolis
Publikováno v:
The Extractive Industries and Society. 8:123-134
Lead has been mined at Mount Isa, Queensland since the 1930s. The city of Mount Isa is located from 0.5 to 2 km to the east of the mine lease and is divided by the Leichhardt River. A key health issue has been lead dispersion via dust from mining act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46211b28b1d600357e0f782843df21d8
https://doi.org/10.1016/j.exis.2020.11.008
https://doi.org/10.1016/j.exis.2020.11.008
Autor:
Joshua J. Woods, James H. Lovett, Zhouyang Huang, A. Paden King, Barry Lai, Hugh H. Harris, Justin J. Wilson
Publikováno v:
Chemical Communications. 57:11189-11192
The photophysical and photochemical properties of two Pt(IV)Re(I) conjugates were studied via both experimental and computational methods. Both conjugates exhibit modest photocytotoxicity against ovarian cancer cells. X-ray fluorescence microscopy sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1375a0cb96053c0e59589d6a4a3d6559
https://doi.org/10.1039/d1cc04669a
https://doi.org/10.1039/d1cc04669a
Autor:
Graham N. George, Ingrid J. Pickering, Glenn L. Millhauser, Graham Roseman, Hugh H. Harris, Kelly L. Summers, George J Sopasis
Publikováno v:
Inorganic chemistry, vol 59, iss 23
Inorg Chem
Inorg Chem
PBT2 (5,7-dichloro-2-[(dimethylamino)methyl]-8-hydroxyquinoline) is a small Cu(II)-binding drug that has been investigated in the treatment of neurodegenerative diseases, namely, Alzheimer’s disease (AD). PBT2 is thought to be highly effective at c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2bec7dcccf5c50fff9167c14b93d3d
https://doi.org/10.1021/acs.inorgchem.0c02754
https://doi.org/10.1021/acs.inorgchem.0c02754
Autor:
George J Sopasis, Graham N. George, Ingrid J. Pickering, Hugh H. Harris, Nicole J. Sylvain, Barry Lai, Natalia V. Dolgova, Ashley K. James, Helen Nichol, Kelly L. Summers, Kenneth B. Gagnon
Publikováno v:
Metallomics. 12:1979-1994
8-Hydroxyquinolines (8HQs) comprise a family of metal-binding compounds that have been used or tested for use in numerous medicinal applications, including as treatments for bacterial infection, Alzheimer's disease, and cancer. Two key 8HQs, CQ (5-ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6088a1029ed092151261dcd1d966cfe0
https://doi.org/10.1039/d0mt00222d
https://doi.org/10.1039/d0mt00222d
Autor:
Matthew P. Sullivan, David C. Goldstone, Muhammad Hanif, Hugh H. Harris, Katja Hummitzsch, Jake W Andersen, Dianna Truong, Kelvin K. H. Tong, James H. Lovett, Tilo Söhnel, Christian G. Hartinger, Ingo Ott, Nils Metzler-Nolte, Tasha R. Steel, Stephen M. F. Jamieson, Andre Prause, Claire M. Weekley
Publikováno v:
Inorganic Chemistry. 59:3281-3289
Metal complexes provide a versatile platform to develop novel anticancer pharmacophores, and they form stable compounds with N-heterocyclic carbene (NHC) ligands, some of which have been shown to inhibit the cancer-related selenoenzyme thioredoxin re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e12beca9a85af62d04cca5037090f83
https://doi.org/10.1021/acs.inorgchem.9b03640
https://doi.org/10.1021/acs.inorgchem.9b03640