Výsledky vyhledávání - "Hugh Giovinazzo"

RepairSwitch: simultaneous functional assessment of homologous recombination vs end joining DNA repair pathways in living cells

Autor: Ruchama C. Steinberg, Jianyong Liu, Ajay M. Vaghasia, Hugh Giovinazzo, Minh-Tam Pham, Dimitri Tselenchuk, Roshan Chikarmane, Michael C. Haffner, William G. Nelson, Srinivasan Yegnasubramanian

DNA repair pathways are frequently defective in human cancers. DNA double strand breaks (DSBs) are most often repaired by either homologous recombination (HR) or non-homologous end joining (NHEJ). Alterations in repair pathways can indicate sensitivi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f6a4e6862d1a17af93e9152c165ddcd
https://doi.org/10.1101/2023.01.17.524235

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A high-throughput screen of pharmacologically active compounds for inhibitors of UHRF1 reveals epigenetic activity of anthracycline derivative chemotherapeutic drugs

Autor: Jianyong Liu, William G. Nelson, Hugh Giovinazzo, David M. Esopi, Akshay Bhamidipati, Nicolas Wyhs, Srinivasan Yegnasubramanian, Yash Jain, David Walker, Ajay Vaghasia, Jianya Zhou

Publikováno v: Oncotarget

DNA methylation can mediate epigenetic silencing of tumor suppressor and cancer protective genes. The protein ubiquitin-like containing PHD and ring finger domains 1 (UHRF1) is an essential component in cells for DNA methylation maintenance. The SET-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb827409611c44175a0e3ca182ac94a
http://europepmc.org/articles/PMC6508961

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Mononuclear phagocyte system function and nanoparticle pharmacology in obese and normal weight ovarian and endometrial cancer patients

Autor: David A. Barrow, Jeannette T. Bensen, Hugh Giovinazzo, Laura H. Hendrix, William C. Zamboni, Brittney Roberts Starling, Laura Farnan, Andrew T. Lucas, Parag Kumar, Paola A. Gehrig, Gina Song

Publikováno v: Cancer Chemotherapy and Pharmacology. 83:61-70

PURPOSE: Obesity may alter mononuclear phagocyte system (MPS) function and the pharmacology and efficacy of nanoparticles therapies, such as PEGylated liposomal doxorubicin (PLD). We aimed to evaluate relationships between hormone and chemokine media

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a6b086dcf88fc15b5e734bd9dc6fcb
https://doi.org/10.1007/s00280-018-3702-9

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Therapeutic targeting of preleukemia cells in a mouse model of

Autor: Hannah J, Uckelmann, Stephanie M, Kim, Eric M, Wong, Charles, Hatton, Hugh, Giovinazzo, Jayant Y, Gadrey, Andrei V, Krivtsov, Frank G, Rücker, Konstanze, Döhner, Gerard M, McGeehan, Ross L, Levine, Lars, Bullinger, George S, Vassiliou, Scott A, Armstrong

Publikováno v: Science (New York, N.Y.). 367(6477)

The initiating mutations that contribute to cancer development are sometimes present in premalignant cells. Whether therapies targeting these mutations can eradicate premalignant cells is unclear. Acute myeloid leukemia (AML) is an attractive system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7180ea71d666e5b0c2c3ddecb2afd3f9
https://pubmed.ncbi.nlm.nih.gov/32033969

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Simultaneous quantitative determination of 5-aza-2′-deoxycytidine genomic incorporation and DNA demethylation by liquid chromatography tandem mass spectrometry as exposure-response measures of nucleoside analog DNA methyltransferase inhibitors

Autor: Teresia Wanjiku, William G. Nelson, Hugh Giovinazzo, Jianyong Liu, Srinivasan Yegnasubramanian, Nicole M. Anders, Michelle A. Rudek, Ajay Vaghasia, Jianya Zhou

Publikováno v: Journal of Chromatography B. 1022:38-45

The epigenetic and anti-cancer activities of the nucleoside analog DNA methyltransferase (DNMT) inhibitors decitabine (5-aza-2′-deoxycytidine, DAC), azacitidine, and guadecitabine are thought to require cellular uptake, metabolism to 5-aza-2′-deo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6e8267cf3fa584f2be09bcbca1bde9
https://doi.org/10.1016/j.jchromb.2016.03.029

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Abstract 2383: RepairSwitch: a novel cell-based functional assay for simultaneous measurement of homologous recombination and non-homologous end joining mediated DNA repair

Autor: Ajay Vaghasia, Minh-Tam Pham, Hugh Giovinazzo, Ruchama C. Steinberg, Srinivasan Yegnasubramanian, Roshan Chikarmane, Jianyong Liu, William B. Nelson, Dimitri Tselenchuk

Publikováno v: Cancer Research. 80:2383-2383

DNA repair pathways are frequently defective in human cancers. DNA double stranded breaks (DSBs) are most often repaired by either homologous recombination (HR) or non-homologous end joining (NHEJ). Alterations in repair pathways can indicate sensiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3425819f88c9cc8ea9d251397f24258
https://doi.org/10.1158/1538-7445.am2020-2383

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Technetium Tc 99m sulfur colloid phenotypic probe for the pharmacokinetics and pharmacodynamics of PEGylated liposomal doxorubicin in women with ovarian cancer

Autor: Beth A. Zamboni, Marija Ivanovic, Paola A. Gehrig, William C. Zamboni, Hugh Giovinazzo, Linda Van Le, Arif Sheikh, Daniel L. Clarke-Pearson, Richard Kowalsky, Wendy R. Brewster, Victoria L. Bae-Jump, Kristina M Brooks, Gina Song, Ann Whitlow, Mark D. Walsh, Whitney P. Caron, Parag Kumar

Publikováno v: Cancer Chemotherapy and Pharmacology. 77:565-573

Significant variability in the pharmacokinetics and pharmacodynamics of PEGylated liposomal doxorubicin (PLD) exists. PLD undergoes clearance via the mononuclear phagocyte system (MPS). Technetium Tc 99m sulfur colloid (TSC) is approved for imaging M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41cf4e3c88e637111da892f6a2ad95dc
https://doi.org/10.1007/s00280-015-2945-y

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Time-Resolved Fluorescence Resonance Energy Transfer Assay for Discovery of Small-Molecule Inhibitors of Methyl-CpG Binding Domain Protein 2

Autor: David Walker, William G. Nelson, Hugh Giovinazzo, Nicolas Wyhs, Srinivasan Yegnasubramanian

Publikováno v: SLAS Discovery. 19:1060-1069

Methylated DNA binding proteins such as Methyl-CpG Binding Domain Protein 2 (MBD2) can transduce DNA methylation alterations into a repressive signal by recruiting transcriptional co-repressor complexes. Interfering with MBD2 could lead to reactivati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877f7f8372db04799ef5a3d04bcf918b
https://doi.org/10.1177/1087057114526433

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Contribution of tumoral and host solute carriers to clinical drug response

Autor: Jason A. Sprowl, Hugh Giovinazzo, Alex Sparreboom, Torben Stamm Mikkelsen

Publikováno v: Sprowl, J A, Mikkelsen, T S, Giovinazzo, H & Sparreboom, A 2012, ' Contribution of tumoral and host solute carriers to clinical drug response ', Drug Resistance Updates, vol. 15, no. 1-2, pp. 5-20 . https://doi.org/10.1016/j.drup.2012.01.009

Members of the solute carrier family of transporters are responsible for the cellular uptake of a broad range of endogenous compounds and xenobiotics in multiple tissues. Several of these solute carriers are known to be expressed in cancer cells or c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127e9c39447213ffa286e121819208eb
https://doi.org/10.1016/j.drup.2012.01.009

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Abstract 5881: Novel inhibitors of the epigenetic reader protein MBD2

Autor: Akshay Bhamidipati, Traci J. Speed, Yonggang Zhang, Nate Brennen, Jianyong Liu, Theodore L. DeWeese, William G. Nelson, Zachary R. Reichert, Hugh Giovinazzo, Ruchama C. Steinberg, Xiaohui Lin, Ajay Vaghasia, David M. Esopi, Andries M. Bergman, Srinivasan Yegnasubramanian, Matthew Vaughn, Yash Jain, Nicolas Wyhs

Publikováno v: Cancer Research. 78:5881-5881

DNA hypermethylation can trigger silencing of tumor suppressor genes during cancer development and progression, partly through binding by methylated-DNA binding proteins (MBD), such as MBD2, that function as “epigenetic readers” and recruit co-re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c649a89a0fc472b862529f19c742707
https://doi.org/10.1158/1538-7445.am2018-5881

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