Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Hugh D. Mitchell"'
A crucial role for dynamic expression of components encoding the negative arm of the circadian clock
Autor:
Bin Wang, Xiaoying Zhou, Arminja N. Kettenbach, Hugh D. Mitchell, Lye Meng Markillie, Jennifer J. Loros, Jay C. Dunlap
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract In the Neurospora circadian system, the White Collar Complex (WCC) drives expression of the principal circadian negative arm component frequency (frq). FRQ interacts with FRH (FRQ-interacting RNA helicase) and CKI, forming a stable complex t
Externí odkaz:
https://doaj.org/article/e770b14f8af64b27bff68f0d13c8136c
Autor:
Song Feng, Emily Heath, Brett Jefferson, Cliff Joslyn, Henry Kvinge, Hugh D. Mitchell, Brenda Praggastis, Amie J. Eisfeld, Amy C. Sims, Larissa B. Thackray, Shufang Fan, Kevin B. Walters, Peter J. Halfmann, Danielle Westhoff-Smith, Qing Tan, Vineet D. Menachery, Timothy P. Sheahan, Adam S. Cockrell, Jacob F. Kocher, Kelly G. Stratton, Natalie C. Heller, Lisa M. Bramer, Michael S. Diamond, Ralph S. Baric, Katrina M. Waters, Yoshihiro Kawaoka, Jason E. McDermott, Emilie Purvine
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-21 (2021)
Abstract Background Representing biological networks as graphs is a powerful approach to reveal underlying patterns, signatures, and critical components from high-throughput biomolecular data. However, graphs do not natively capture the multi-way rel
Externí odkaz:
https://doaj.org/article/3730664a2b894f34b1b4e404f44398c0
Autor:
Paul D. Piehowski, Ying Zhu, Lisa M. Bramer, Kelly G. Stratton, Rui Zhao, Daniel J. Orton, Ronald J. Moore, Jia Yuan, Hugh D. Mitchell, Yuqian Gao, Bobbie-Jo M. Webb-Robertson, Sudhansu K. Dey, Ryan T. Kelly, Kristin E. Burnum-Johnson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Imaging mass spectrometry is a powerful emerging tool for mapping the spatial distribution of biomolecules across tissue surfaces. Here the authors showcase an automated technology for deep proteome imaging that utilizes ultrasensitive microfluidics
Externí odkaz:
https://doaj.org/article/e3b5a3a1d7b147dd83097e22370e56dc
Autor:
Amy C. Sims, Hugh D. Mitchell, Lisa E. Gralinski, Jennifer E. Kyle, Kristin E. Burnum-Johnson, Mariam Lam, M. Leslie Fulcher, Ande West, Richard D. Smith, Scott H. Randell, Thomas O. Metz, Timothy P. Sheahan, Katrina M. Waters, Ralph S. Baric
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Tissue- and cell-specific expression patterns are highly variable within and across individuals, leading to altered host responses after acute virus infection. Unraveling key tissue-specific response patterns provides novel opportunities for
Externí odkaz:
https://doaj.org/article/a299fa7ab51f41d792827fb0f696c144
Autor:
Tania Chroumpi, Mao Peng, Lye Meng Markillie, Hugh D. Mitchell, Carrie D. Nicora, Chelsea M. Hutchinson, Vanessa Paurus, Nikola Tolic, Chaevien S. Clendinen, Galya Orr, Scott E. Baker, Miia R. Mäkelä, Ronald P. de Vries
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
The filamentous ascomycete Aspergillus niger has received increasing interest as a cell factory, being able to efficiently degrade plant cell wall polysaccharides as well as having an extensive metabolism to convert the released monosaccharides into
Externí odkaz:
https://doaj.org/article/e1d1f3f17cfe4d7aa43a848c4d69d93d
Autor:
Rene M. Boiteau, Lye Meng Markillie, David W. Hoyt, Dehong Hu, Rosalie K. Chu, Hugh D. Mitchell, Ljiljana Pasa-Tolic, Janet K. Jansson, Christer Jansson
Publikováno v:
mSystems, Vol 6, Iss 1 (2021)
ABSTRACT Iron (Fe) availability has well-known effects on plant and microbial metabolism, but its effects on interspecies interactions are poorly understood. The purpose of this study was to investigate metabolite exchange between the grass Brachypod
Externí odkaz:
https://doaj.org/article/4741e9b20cb645a8ab3f1c6cd0f102fa
Autor:
Hugh D. Mitchell, Amie J. Eisfeld, Kelly G. Stratton, Natalie C. Heller, Lisa M. Bramer, Ji Wen, Jason E. McDermott, Lisa E. Gralinski, Amy C. Sims, Mai Q. Le, Ralph S. Baric, Yoshihiro Kawaoka, Katrina M. Waters
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Despite high sequence similarity between pandemic and seasonal influenza viruses, there is extreme variation in host pathogenicity from one viral strain to the next. Identifying the underlying mechanisms of variability in pathogenicity is a critical
Externí odkaz:
https://doaj.org/article/f32b5429bcb647beb09f1399557d0417
Autor:
Vineet D. Menachery, Lisa E. Gralinski, Hugh D. Mitchell, Kenneth H. Dinnon, Sarah R. Leist, Boyd L. Yount, Rachel L. Graham, Eileen T. McAnarney, Kelly G. Stratton, Adam S. Cockrell, Kari Debbink, Amy C. Sims, Katrina M. Waters, Ralph S. Baric
Publikováno v:
mSphere, Vol 2, Iss 6 (2017)
ABSTRACT Coronaviruses (CoVs) encode a mixture of highly conserved and novel genes, as well as genetic elements necessary for infection and pathogenesis, raising the possibility of common targets for attenuation and therapeutic design. In this study,
Externí odkaz:
https://doaj.org/article/7434bb24ede84ab29da1760f9b1e6e0e
Autor:
Vineet D. Menachery, Hugh D. Mitchell, Adam S. Cockrell, Lisa E. Gralinski, Boyd L. Yount, Rachel L. Graham, Eileen T. McAnarney, Madeline G. Douglas, Trevor Scobey, Anne Beall, Kenneth Dinnon, Jacob F. Kocher, Andrew E. Hale, Kelly G. Stratton, Katrina M. Waters, Ralph S. Baric
Publikováno v:
mBio, Vol 8, Iss 4 (2017)
ABSTRACT While dispensable for viral replication, coronavirus (CoV) accessory open reading frame (ORF) proteins often play critical roles during infection and pathogenesis. Utilizing a previously generated mutant, we demonstrate that the absence of a
Externí odkaz:
https://doaj.org/article/438eeeef29a24edba2f4d738b85fb4c0
Autor:
Hannah Kinmonth-Schultz, Stephen Michael Walker, Kerem Bingol, David W Hoyt, Young-Mo Kim, Lye Meng Markillie, Hugh D Mitchell, Carrie D Nicora, Ronald Taylor, Joy K Ward
Publikováno v:
PLoS ONE, Vol 18, Iss 12, p e0287943 (2023)
Since industrialization began, atmospheric CO2 ([CO2]) has increased from 270 to 415 ppm and is projected to reach 800-1000 ppm this century. Some Arabidopsis thaliana (Arabidopsis) genotypes delayed flowering in elevated [CO2] relative to current [C
Externí odkaz:
https://doaj.org/article/6d6a2f4dbebd4987aeb8901b0c69e194