Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Hugh D C, Smyth"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 10, p 1269 (2024)
In this study we have developed a high-dose dry powder inhaler formulation of indomethacin using a novel approach to carrier-based formulations. Specifically, larger drug particles serve as the carrier for the smaller micronized drug particles, such
Externí odkaz:
https://doaj.org/article/bb7740554ea14d43b32eb603c957d554
Autor:
Leisha M. Armijo, Stephen J. Wawrzyniec, Michael Kopciuch, Yekaterina I. Brandt, Antonio C. Rivera, Nathan J. Withers, Nathaniel C. Cook, Dale L. Huber, Todd C. Monson, Hugh D. C. Smyth, Marek Osiński
Publikováno v:
Journal of Nanobiotechnology, Vol 18, Iss 1, Pp 1-27 (2020)
Abstract Background Novel methods are necessary to reduce morbidity and mortality of patients suffering from infections with Pseudomonas aeruginosa. Being the most common infectious species of the Pseudomonas genus, P. aeruginosa is the primary Gram-
Externí odkaz:
https://doaj.org/article/7930d1949eb14b0b901971b2b96e818d
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0246803 (2021)
Niclosamide (NIC) has demonstrated promising in vitro antiviral efficacy against SARS-CoV-2, the causative agent of the COVID-19 pandemic. Though NIC is already FDA-approved, administration of the currently available oral formulation results in syste
Externí odkaz:
https://doaj.org/article/7b9a8a6ac8854a72a9191dcad8183f84
Autor:
Yuanyuan Xue, Youwu Liao, Haiqiao Wang, Shuang Li, Zhengqing Gu, Michael Adu‐Frimpong, Jiangnan Yu, Ximing Xu, Hugh D. C Smyth, Yuan Zhu
Publikováno v:
Journal of the Science of Food and Agriculture. 103:3628-3637
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::341911d1b812a795979d56734283d1ba
https://doi.org/10.1002/jsfa.12527
https://doi.org/10.1002/jsfa.12527
Autor:
Li Ding, Ashlee D. Brunaugh, Sven Stegemann, Scott V. Jermain, Matthew J. Herpin, Justin Kalafat, Hugh D. C. Smyth
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1213 (2021)
Capsule-based dry powder inhalers (cDPIs) are widely utilized in the delivery of pharmaceutical powders to the lungs. In these systems, the fundamental nature of the interactions between the drug/formulation powder, the capsules, the inhaler device,
Externí odkaz:
https://doaj.org/article/f96b50400fd64ad794997089c4e78a70
Autor:
Xin Hua, Qin Yang, Zhimin Dong, Jiashuo Zhang, Wanjiang Zhang, Qiudong Wang, Shengnan Tan, Hugh D. C. Smyth
Publikováno v:
Drug Delivery, Vol 24, Iss 1, Pp 511-518 (2017)
The objective of this study was to describe the magnetic nanoparticle–drug conjugates for improved control of drug delivery and drug release. The widely used anticancer agent Doxorubicin (DOX) was successfully conjugated via amine groups to the car
Externí odkaz:
https://doaj.org/article/3d5680ad73374e44b1672084b85ac235
Publikováno v:
Journal of Pharmaceutical Sciences. 111:403-416
Monoclonal antibody (mAb) based therapies may provide a valuable new treatment modality for acute and chronic lung diseases, including asthma, respiratory infections, and lung cancer. Currently mAbs are delivered via systemic administration routes, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ab72374f525ff991d61618079a7ae8
https://doi.org/10.1016/j.xphs.2021.08.022
https://doi.org/10.1016/j.xphs.2021.08.022
Autor:
Shayden Fritz, Leisha M. Armijo, Kayla Simpson, Kimberly Lopez, Marek Osinski, Nihal Bandara, Hugh D. C. Smyth, Jian Sheng, Wei Xu
Publikováno v:
Colloidal Nanoparticles for Biomedical Applications XVIII.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c629127bb987f487710873ca58002f67
https://doi.org/10.1117/12.2654656
https://doi.org/10.1117/12.2654656
Publikováno v:
Pharmaceutics, Vol 12, Iss 11, p 1042 (2020)
Messenger RNA is a class of promising nucleic acid therapeutics to treat a variety of diseases, including genetic diseases. The development of a stable and efficacious mRNA pulmonary delivery system would enable high therapeutic concentrations locall
Externí odkaz:
https://doaj.org/article/e2b681aa87a04ae595442d25ab47190e
Publikováno v:
Fundamentals of Drug Delivery. :449-469
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a2148815edc8c19fdaf73f1e7f8446d
https://doi.org/10.1002/9781119769644.ch18
https://doi.org/10.1002/9781119769644.ch18