Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Hugh Cahill"'
Autor:
Seerapani Gopaluni, Rona Smith, Donna Goymer, Hugh Cahill, Elizabeth Broadhurst, Elizabeth Wallin, Mark McClure, Afzal Chaudhry, David Jayne
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-13 (2022)
Abstract Background Primary systemic vasculitis (PSV) is a heterogeneous group of autoimmune conditions. There is an unmet need for alternative therapies that lead to sustained remission in patients with refractory disease. Alemtuzumab, an anti-CD52
Externí odkaz:
https://doaj.org/article/2a7289713dcb49f9aa70eb54f28c80b3
Publikováno v:
PLoS Genetics, Vol 11, Iss 9, p e1005532 (2015)
Planar cell polarity (PCP) signaling controls the global orientation of surface structures, such as hairs and bristles, in both vertebrates and invertebrates. In Frizzled6(-/-) (Fz6(-/-)) mice, hair follicle orientations on the head and back are near
Externí odkaz:
https://doaj.org/article/699f34551b3c46308ec230e7c2ba1ba6
Autor:
Hugh Cahill, Jeremy Nathans
Publikováno v:
PLoS ONE, Vol 3, Iss 4, p e2055 (2008)
The optokinetic reflex (OKR), which serves to stabilize a moving image on the retina, is a behavioral response that has many favorable attributes as a test of CNS function. The OKR requires no training, assesses the function of diverse CNS circuits,
Externí odkaz:
https://doaj.org/article/74042d6dd095406180809d17a0995515
Autor:
Rona M Smith, Elizabeth Broadhurst, David Jayne, Donna Goymer, Hugh Cahill, Mark McClure, Seerapani Gopaluni
Publikováno v:
Rheumatology. 58
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c7f233f9bb2577cf2977e64a558470d
https://doi.org/10.1093/rheumatology/kez063.026
https://doi.org/10.1093/rheumatology/kez063.026
Publikováno v:
Journal of Clinical Investigation. 121:3528-3541
The drug development process for CNS indications is hampered by a paucity of preclinical tests that accurately predict drug efficacy in humans. Here, we show that a wide variety of CNS-active drugs induce characteristic alterations in visual stimulus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317d62d0128bd842b2b283090a6ab50e
https://doi.org/10.1172/jci45557
https://doi.org/10.1172/jci45557
Publikováno v:
Neuron. 61:852-864
SummaryTranscriptional regulatory networks that control the morphologic and functional diversity of mammalian neurons are still largely undefined. Here we dissect the roles of the highly homologous POU-domain transcription factors Brn3a and Brn3b in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0039b7074bd26ba5fcbf61d137844bc3
https://doi.org/10.1016/j.neuron.2009.01.020
https://doi.org/10.1016/j.neuron.2009.01.020
Publikováno v:
JARO - Journal of the Association for Research in Otolaryngology. 3:403-417
Sensory deprivation has been shown to exert detrimental effects on the structure and function of central sensory systems. Congenital deafness represents an extreme form of auditory deprivation, and in the adult white cat, synapses between auditory ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dae80f2445a55937e2d2c78716951ac7
https://doi.org/10.1007/s101620020043
https://doi.org/10.1007/s101620020043
Publikováno v:
The Journal of Neuroscience. 21:4761-4771
Wnt signaling has been implicated in the control of cell proliferation and in synapse formation during neural development, and these actions are presumed to be mediated byfrizzledreceptors. In this paper we report the phenotype of mice carrying a tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae5995bfdd47ec9c8fd99598c9ebc85
https://doi.org/10.1523/jneurosci.21-13-04761.2001
https://doi.org/10.1523/jneurosci.21-13-04761.2001
Autor:
Hugh Cahill
Publikováno v:
Alexandria: The Journal of National and International Library and Information Issues. 20:179-181
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83723d3b2ebd460c1188bc0825e60ade
https://doi.org/10.1177/095574900802000108
https://doi.org/10.1177/095574900802000108
Autor:
Neal S. Peachey, Minzhong Yu, Philip M. Smallwood, Xin Ye, Tudor C. Badea, Yanshu Wang, Jeremy Nathans, Hugh Cahill
Publikováno v:
Cell. 141(1)
SummaryDisorders of vascular structure and function play a central role in a wide variety of CNS diseases. Mutations in the Frizzled-4 (Fz4) receptor, Lrp5 coreceptor, or Norrin ligand cause retinal hypovascularization, but the mechanisms by which No
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4880ec33cf13e4ee522478bbe471a394