Výsledky vyhledávání - "Hugh B. Perkin"

PU.1 and the Granulocyte- and Macrophage Colony-Stimulating Factor Receptors Play Distinct Roles in Late-Stage Myeloid Cell Differentiation

Autor: Hugh B. Perkin, Karen L. Anderson, Carol-Gay Anderson, Kent A. Smith, Richard A. Maki, Gary Hermanson, Bruce E. Torbett, Douglas J. Jolly

Publikováno v: Blood. 94:2310-2318

PU.1 is a hematopoietic cell–specific ets family transcription factor. Gene disruption of PU.1 results in a cell autonomous defect in hematopoietic progenitor cells that manifests as abnormal myeloid and B-lymphoid development. Of the myeloid linea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4c6f5ec78aff0802fff662864d229fe
https://doi.org/10.1182/blood.v94.7.2310.419k34_2310_2318

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Targeting and hematopoietic suppression of human CD34+ cells by measles virus

Autor: Hugh B. Perkin, Danelle S. Eto, Marianne Manchester, Bruce E. Torbett, Kent A. Smith

Publikováno v: Journal of virology. 76(13)

The major cause of mortality in measles is generalized suppression of cell-mediated immunity that persists following virus clearance and results in secondary infections. The mechanisms contributing to this long-term immunosuppression are not clear. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9735acd0b53a227bd27d48c70d3f8536
https://pubmed.ncbi.nlm.nih.gov/12050376

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PU.1 is a lineage-specific regulator of tyrosine phosphatase CD45

Autor: Bruce E. Torbett, Karen L. Anderson, Hugh B. Perkin, Stacy L. Nelson, Kent A. Smith, Michael J. Klemsz

Publikováno v: The Journal of biological chemistry. 276(10)

The hematopoietic cell-specific ets family transcription factor PU.1 regulates many lymphoid and myeloid genes. We have determined that PU.1 is critical for lineage-specific expression of the tyrosine phosphatase CD45. CD45 is expressed exclusively i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81bbc595369b3f2cc174c46f71b81436
https://pubmed.ncbi.nlm.nih.gov/11114304

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Transcription factor PU.1 is necessary for development of thymic and myeloid progenitor-derived dendritic cells

Autor: Hugh B. Perkin, Karen L. Anderson, Charles D. Surh, Richard A. Maki, Bruce E. Torbett, Sara Venturini

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 164(4)

Dendritic cells (DCs) are a heterogeneous population of cells that are specialized for Ag processing and presentation. These cells are believed to derive from both myeloid- and lymphoid-committed precursors. Normal human PBMC-derived, human CD14+ cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265b83724de59fa17500806ec458a005
https://pubmed.ncbi.nlm.nih.gov/10657634

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