Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Hugh B Nicholas"'
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e13999 (2010)
Phylogenetic study of protein sequences provides unique and valuable insights into the molecular and genetic basis of important medical and epidemiological problems as well as insights about the origins and development of physiological features in pr
Externí odkaz:
https://doaj.org/article/725716e6756e4a79848a6cfbacac013e
Publikováno v:
BioTechniques, Vol 32, Iss 3, Pp 572-591 (2002)
We present an overview of multiple sequence alignments to outline the practical consequences for the choices among different techniques and parameters. We begin with a discussion of the scoring methods for quantifying the quality of a multiple sequen
Externí odkaz:
https://doaj.org/article/c52d9258078648d7bdbd321b673f65f5
Publikováno v:
BioTechniques, Vol 28, Iss 6, Pp 1174-1191 (2000)
We provide a detailed overview of the choices inherent in performing a sequence database search, including the choice of algorithm, substitution matrix and gap model. Each of these choices has implications that can be described as restrictions on the
Externí odkaz:
https://doaj.org/article/4cc47a63e4544b9ab5d50984c1c5143a
Autor:
Jimmy Torres, Ricardo Gonzalez Mendez, Alexander J. Ropelewski, Hugh B. Nicholas, Pallavi Ishwad
Publikováno v:
XSEDE
Over the last two decades, there has been a general acknowledgement within the scientific community that modern biology is becoming increasingly computational and to be prepared biologists need to build computational skills.We present work in assisti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23e1ae3f07b4c38eb9860cb3ff57369f
https://doi.org/10.1145/2949550.2949641
https://doi.org/10.1145/2949550.2949641
Autor:
Troy Wymore, Kimberly R. Lesnock, Carlos A. Ramirez-Mondragon, Hugh B. Nicholas, Agnieszka Szarecka
Publikováno v:
Protein Engineering, Design and Selection. 24:801-809
Class D β-lactamases, a major source of bacterial resistance to β-lactam antibiotic therapies, represent a distinct subset of the β-lactamase superfamily. They share a serine hydrolase mechanism with Classes A/C vs. Class B. Further understanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272cf92e0480e495d9af0397ee5762b0
https://doi.org/10.1093/protein/gzr041
https://doi.org/10.1093/protein/gzr041
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 38:738-743
Post-translational sulfation of tyrosines affects the affinity and binding of at least some chemokine receptors to their ligand(s) and has been hypothesized to be a feature in all chemokine receptors. This binding initiates downstream signaling casca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082f3bc1c9fd0bb361ee551342ffceb2
https://doi.org/10.1165/rcmb.2007-0118oc
https://doi.org/10.1165/rcmb.2007-0118oc
Autor:
James Tyus, Gary Kelley, Hugh B. Nicholas, Xiaofei Wang, Samuel N. Nahashon, Alexander J. Ropelewski, Carl E. Darris
Publikováno v:
BMC Genomics
Background Guinea fowl (Numidia meleagris) production as an alternative source of meat and poultry has shown potential for economic viability. However, there has been little progress in characterizing the transcriptome of the guinea fowl. In this stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7d86eab8c1e97636bdb3c86fd1bd38
http://europepmc.org/articles/PMC4432510
http://europepmc.org/articles/PMC4432510
Autor:
John E. Shively, Michael T. Davis, Hugh B. Nicholas, David A. Keire, Robert C. Backus, Joseph R. Reeve, Grace L. Rosenquist, Terry D. Lee, Peter Chew
Publikováno v:
Biochemical and Biophysical Research Communications. 348:819-825
Evidence suggests that amino terminal extensions of CCK-8 affect the carboxyl terminal bioactive region of CCK. Cat CCK-58 was purified by low pressure reverse phase and ion-exchange chromatography steps and several reverse phase HPLC steps. The puri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::495937f469a9a392f0577596a74b4a08
https://doi.org/10.1016/j.bbrc.2006.07.081
https://doi.org/10.1016/j.bbrc.2006.07.081
Molecular recognition of aldehydes by aldehyde dehydrogenase and mechanism of nucleophile activation
Autor:
Hugh B. Nicholas, Alexander D. MacKerell, David W. Deerfield, Troy Wymore, Samuel S. Cho, John Hempel
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 57:758-771
Experimental structural data on the state of substrates bound to class 3 Aldehyde Dehydrogenases (ALDH3A1) is currently unknown. We have utilized molecular mechanics (MM) simulations, in conjunction with new force field parameters for aldehydes, to s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb2a2e100d8cf50ea9760cb492905891
https://doi.org/10.1002/prot.20256
https://doi.org/10.1002/prot.20256