Additional file 1: Data S1. of The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinsonâ s disease

Autor: Finkelstein, David, Billings, Jessica, Adlard, Paul, Ayton, Scott, Sedjahtera, Amelia, Masters, Colin, Wilkins, Simon, Shackleford, David, Charman, Susan, Bal, Wojciech, Zawisza, Izabela, Kurowska, Ewa, Gundlach, Andrew, Ma, Sheri, Bush, Ashley, Hare, Dominic, Doble, Philip, Crawford, Simon, Gautier, Elisabeth, Parsons, Jack, Huggins, Penny, Barnham, Kevin, Cherny, Robert

Potentiometric determination of PBT434 affinity for Fe(III), Fe(II) Cu(II) and Zn(II) Ions. Figure S2. Effect of PBT434 on brain iron and peripheral markers of iron metabolism. Data S3. Pharmacokinetics, pharmacodynamics and safety. Figure S4. Experi

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Correction to: The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease.

Autor: Finkelstein DI; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, 3010, Australia. d.finkelstein@florey.edu.au., Billings JL; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, 3010, Australia., Adlard PA; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, 3010, Australia., Ayton S; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, 3010, Australia., Sedjahtera A; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, 3010, Australia., Masters CL; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, 3010, Australia., Wilkins S; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, 3010, Australia., Shackleford DM; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia., Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia., Bal W; The Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland., Zawisza IA; The Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland., Kurowska E; The Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland., Gundlach AL; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, 3010, Australia., Ma S; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, 3010, Australia., Bush AI; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, 3010, Australia., Hare DJ; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, 3010, Australia.; Elemental Bio-Imaging Facility, The University of Technology Sydney, Broadway, Ultimo, NSW, 2007, Australia., Doble PA; Elemental Bio-Imaging Facility, The University of Technology Sydney, Broadway, Ultimo, NSW, 2007, Australia., Crawford S; Australia Electron Microscope Unit, School of Biosciences, The University of Melbourne, Melbourne, VIC, 3010, Australia., Gautier ECL; Prana Biotechnology Ltd, Parkville, VIC, 3052, Australia., Parsons J; Prana Biotechnology Ltd, Parkville, VIC, 3052, Australia., Huggins P; Prana Biotechnology Ltd, Parkville, VIC, 3052, Australia., Barnham KJ; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, 3010, Australia.; Bio21 Institute and Department of Pharmacology and Therapeutics, The University of Melbourne, Melbourne, VIC, 3010, Australia., Cherny RA; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, 3010, Australia. rcherny@unimelb.edu.au.; Prana Biotechnology Ltd, Parkville, VIC, 3052, Australia. rcherny@unimelb.edu.au.

Publikováno v: Acta neuropathologica communications [Acta Neuropathol Commun] 2021 Sep 29; Vol. 9 (1), pp. 161. Date of Electronic Publication: 2021 Sep 29.