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Akademický článek
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Autor:
López-Perrote, Andres, Hug, Nele, González-Corpas, Ana, Rodríguez, Carlos F, Serna, Marina, García-Martín, Carmen, Caceres, Javier F, Llorca, Oscar, Boskovic, Jasminka, Fernandez-Leiro, Rafael, Llorca Blanco, Oscar Antonio
Publikováno v:
Lopez-Perrote, A, Hug, N, González-Corpas, A, F Rodríguez, C, Serna, M, García-Martín, C, Boskovic, J, Fernandez-Leiro, R, Caceres, J F & Llorca, O 2020, ' Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM ', eLIFE . https://doi.org/10.7554/eLife.63042
eLife, Vol 9 (2020)
eLife
Repisalud
Instituto de Salud Carlos III (ISCIII)
eLife, Vol 9 (2020)
eLife
Repisalud
Instituto de Salud Carlos III (ISCIII)
Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that degrades aberrant mRNAs and also regulates the expression of a wide range of physiological transcripts. RUVBL1 and RUVBL2 AAA-ATPases form an hetero-hexameric ring that is part of seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf3c5a5e6df74f7e90b980a4cefe99b
https://hdl.handle.net/20.500.12105/12498
https://hdl.handle.net/20.500.12105/12498
Autor:
Rio-Machin, Ana, Villiamy, Tom, Hug, Nele, Walne, Amanda, Tawana, Kiran, Cardoso, Shirleny, Ellison, Alicia, Pontikos, Nikolas, Wang, Jun, Tummala, Hemanth, Al Seraihi, Ahad Fahad H., Alnajar, Jenna, Bewicke-Copley, Findlay, Barnett, Michael, Armes, Hannah, Bloor, Adrian, Bödör, Csabo, Bowen, David, Fenaux, Pierre, Green, Andrew, Hallahan, Andrew, Hjorth-Hansen, Henrik, Hossein, Upal, Killick, Sally, Lawson, Sarah, Layton, Mark, Male, Alison M., Marsh, Judith, Mehta, Priyanka, Mous, Rogier, Nomdedéu, Josep F., Owen, Carolyn, Pavlu, Jiri, Payne, Elspeth, Protheroe, Rachel E., Preudhomme, Claude, Pujol-Moix, Nuria, Renneville, Aline, Russell, Nigel, Saggar, Anand, Sciuccati, Gabriela, Taussig, David, Toze, Cynthia, Uyttebroeck, Anne, Vandenberghe, Peter, Schlegelberger, Brigitte, Ripperger, Tim, Steinemann, Doris, Wu, John, Mason, Joanne, Page, Paula, Akiki, Susanna, Reay, Kim, Cavenagh, Jamie D., Plagnol, Vincent, Caceres, Javier F., Fitzgibbon, Jude, Dokal, Inderjeet
Externí odkaz:
https://hdl.handle.net/11250/2722007
Akademický článek
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Publikováno v:
In Biophysical Journal 11 February 2022 121(3) Supplement 1:481a-481a
Autor:
Melero, Roberto, Hug, Nele, López-Perrote, Andrés, Yamashita, Akio, Cáceres, Javier F., Llorca, Oscar
Publikováno v:
Melero, R, Hug, N, Lopez-Perrote, A, Yamashita, A, Cáceres, J F & Llorca, O 2016, ' The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation ', Nature Communications, vol. 7, 10585 . https://doi.org/10.1038/ncomms10585
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Digital.CSIC. Repositorio Institucional del CSIC
instname
12 p.-7 fig.
Nonsense-mediated decay (NMD) is a messenger RNA quality-control pathway triggered by SMG1-mediated phosphorylation of the NMD factor UPF1. In recent times, the RNA helicase DHX34 was found to promote mRNP remodelling, leading to ac
Nonsense-mediated decay (NMD) is a messenger RNA quality-control pathway triggered by SMG1-mediated phosphorylation of the NMD factor UPF1. In recent times, the RNA helicase DHX34 was found to promote mRNP remodelling, leading to ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::553e64338527b3a8a1efcfcd76fa62df
https://www.pure.ed.ac.uk/ws/files/23633788/ncomms10585.pdf
https://www.pure.ed.ac.uk/ws/files/23633788/ncomms10585.pdf
Autor:
Casadio, Angela, Longman, Dasa, Hug, Nele, Delavaine, Laurent, Vallejos Baier, Raúl, Alonso, Claudio R, Cáceres, Javier F
Publikováno v:
Casadio, A, Longman, D, Hug, N, Delavaine, L, Vallejos Baier, R, Alonso, C R & Cáceres, J F 2015, ' Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals ', EMBO Reports, vol. 16, no. 1, pp. 71-78 . https://doi.org/10.15252/embr.201439183
EMBO Reports
EMBO Reports
Nonsense‐mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNAs harboring premature termination codons (PTCs). We have conducted a genome‐wide RNAi screen in Caenorhabditis elegans that resulted in the identification of five no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ac0b6472f6e8e9f0f9b4c9d6fa706dbb
https://hdl.handle.net/20.500.11820/fcbf6bc4-be3d-4c77-a549-bb8c7ea62a5f
https://hdl.handle.net/20.500.11820/fcbf6bc4-be3d-4c77-a549-bb8c7ea62a5f
Akademický článek
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Autor:
Hug, Nele, Cáceres, Javier F.
Publikováno v:
Hug, N & Cáceres, J F 2014, ' The RNA Helicase DHX34 Activates NMD by Promoting a Transition from the Surveillance to the Decay-Inducing Complex ', Cell Reports, vol. 8, no. 6, pp. 1845-1856 . https://doi.org/10.1016/j.celrep.2014.08.020
Cell Reports, Vol 8, Iss 6, Pp 1845-1856 (2014)
Cell Reports, Vol 8, Iss 6, Pp 1845-1856 (2014)
SummaryNonsense-mediated decay (NMD) is a surveillance mechanism that degrades aberrant mRNAs. A complex comprising SMG1, UPF1, and the translation termination factors eRF1 and eRF3 (SURF) is assembled in the vicinity of a premature termination codon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ab295828f89e4366ea9a898623594da2
https://www.pure.ed.ac.uk/ws/files/16966127/The_RNA_Helicase_DHX34_Activates_NMD_by_Promoting_a_Transition_from_the_Surveillance_to_the_Decay_Inducing_Complex.pdf
https://www.pure.ed.ac.uk/ws/files/16966127/The_RNA_Helicase_DHX34_Activates_NMD_by_Promoting_a_Transition_from_the_Surveillance_to_the_Decay_Inducing_Complex.pdf
Akademický článek
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