Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain

Autor: He, Yingfang, Grether, Uwe, Taddio, Marco F., Meier, Carla, Keller, Claudia, Edelmann, Martin R., Honer, Michael, Huber, Sylwia, Wittwer, Matthias B., Heer, Dominik, Richter, Hans, Collin, Ludovic, Hug, Melanie N., Hilbert, Manuel, Postmus, Annemarieke G.J., Stevens, Anna Floor, van der Stelt, Mario, Krämer, Stefanie D., Schibli, Roger, Mu, Linjing, Gobbi, Luca C.

Publikováno v: In European Journal of Medicinal Chemistry 5 December 2022 243

Structure-Guided Discovery of cis-Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors

Autor: Kuhn, Bernd, Ritter, Martin, Hornsperger, Benoit, Bell, Charles, Kocer, Buelent, Rombach, Didier, Lutz, Marius D. R., Gobbi, Luca, Kuratli, Martin, Bartelmus, Christian, Bürkler, Markus, Koller, Raffael, Tosatti, Paolo, Ruf, Iris, Guerard, Melanie, Pavlovic, Anto, Stephanus, Juliane, O’Hara, Fionn, Wetzl, Dennis, Saal, Wiebke, Stihle, Martine, Roth, Doris, Hug, Melanie, Huber, Sylwia, Heer, Dominik, Kroll, Carsten, Topp, Andreas, Schneider, Manfred, Gertsch, Jürg, Glasmacher, Sandra, van der Stelt, Mario, Martella, Andrea, Wittwer, Matthias Beat, Collin, Ludovic, Benz, Jörg, Richter, Hans, Grether, Uwe

Publikováno v: Journal of Medicinal Chemistry; October 2024, Vol. 67 Issue: 20 p18448-18464, 17p

Additional file 1 of Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies

Autor: Moors, Tim E., Mona, Daniel, Luehe, Stefan, Duran-Pacheco, Gonzalo, Spycher, Liz, Mundigl, Olaf, Kaluza, Klaus, Huber, Sylwia, Hug, Melanie N., Kremer, Thomas, Ritter, Mirko, Dziadek, Sebastian, Dernick, Gregor, van de Berg, Wilma D. J., Britschgi, Markus

Additional file 1. Supplementary tables and figures: Table S1: AlphaLISA® antibody specifics; Table S2: RPA antibody specifics. Fig. S1: AlphaLISA® hookpoints & standard curves. Fig. S2: Total protein & RPA neuronal and synaptic markers. Fig. S3: A

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Detailed structural orchestration of Lewy pathology in Parkinson's disease as revealed by 3D multicolor STED microscopy

Autor: Moors, Tim E., Maat, Christina A., Niedieker, Daniel, Mona, Daniel, Petersen, Dennis, Timmermans-Huisman, Evelien, Kole, Jeroen, El-Mashtoly, Samir F., Zago, Wagner, Barbour, Robin, Mundigl, Olaf, Kaluza, Klaus, Huber, Sylwia, Hug, Melanie N., Kremer, Thomas, Ritter, Mirko, Dziadek, Sebastian, Geurts, Jeroen J.G., Gerwert, Klaus, Britschgi, Markus, Berg, Wilma D.J. van de

Publikováno v: Moors, T E, Maat, C A, Niedieker, D, Mona, D, Petersen, D, Timmermans-Huisman, E, Kole, J, El-Mashtoly, S F, Zago, W, Barbour, R, Mundigl, O, Kaluza, K, Huber, S, Hug, M N, Kremer, T, Ritter, M, Dziadek, S, Geurts, J J G, Gerwert, K, Britschgi, M & Berg, W D J V D 2018, ' Detailed structural orchestration of Lewy pathology in Parkinson's disease as revealed by 3D multicolor STED microscopy ', Biorxiv, pp. 470476 . https://doi.org/10.1101/470476
Biorxiv. Cold Spring Harbor Laboratory Press
Biorxiv

Post-translational modifications of alpha-synuclein (aSyn), in particular phosphorylation at Serine 129 (Ser129-p) and truncation of its C-terminus (CTT), have been implicated in Parkinson's disease (PD) pathophysiology. Although great interest has e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0be70408ef3a280cdc1fa7aae8176f77
https://research.vumc.nl/en/publications/cec22877-3a96-4c04-aedb-cde9ee301e08