Validation of a distinct psoriatic arthritis risk variant at IL23R

Autor: Budu-Aggrey, A., Bowes, J., Loehr, S., Uebe, S., Zervou, M.I., Helliwell, P., Ryan, A.W., Kane, D., Korendowych, E., Giardina, E., Packham, J., McManus, R., FitzGerald, O., McHugh, N., Behrens, F., Burkhardt, H., Huffmeier, U., Ho, P., Martin, J., Castaneda, S., Goulielmos, G., Reis, A., Barton, A.

Background: PsA is an inflammatory arthritis that is associated with psoriasis and is estimated to present in ∼14% of psoriasis patients in the UK. PsA is a complex disease that is influenced by both genetic and environmental factors. Genetic studi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______610::91bd4c964859e77575a662e79709b5f2
https://publica.fraunhofer.de/handle/publica/244841

Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis

Autor: Bowes, J, Budu-Aggrey, A, Huffmeier, U, Uebe, S, Steel, K, Hebert, HL, Wallace, C, Massey, J, Bruce, IN, Bluett, J, Feletar, M, Morgan, AW, Marzo-Ortega, H, Donohoe, G, Morris, DW, Helliwell, P, Ryan, AW, Kane, D, Warren, RB, Korendowych, E, Alenius, G-M, Giardina, E, Packham, J, McManus, R, FitzGerald, O, McHugh, N, Brown, MA, Ho, P, Behrens, F, Burkhardt, H, Reis, A, Barton, A

Publikováno v: Bowes, J, Budu-Aggrey, A, Huffmeier, U, Uebe, S, Steel, K, Hebert, H L, Wallace, C, Massey, J, Bruce, I N, Bluett, J, Feletar, M, Morgan, A W, Marzo-Ortega, H, Donohoe, G, Morris, D W, Helliwell, P, Ryan, A W, Kane, D, Warren, R B, Korendowych, E, Alenius, G-M, Giardina, E, Packham, J, McManus, R, FitzGerald, O, McHugh, N, Brown, M A, Ho, P, Behrens, F, Burkhardt, H, Reis, A & Barton, A 2015, ' Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis ', Nature Communications, vol. 6, 6046 . https://doi.org/10.1038/ncomms7046
Bowes, J, Budu-Aggrey, A, Huffmeier, U, Uebe, S, Steel, K, Hebert, H, Wallace, C, Massey, J, Bruce, I N, Bluett, J, Feletar, M, Morgan, A W, Marzo-Ortega, H, Donohoe, G, Morris, D W, Helliwell, P, Ryan, A W, Kane, D, Warren, R B, Korendowych, E, Alenius, G-M, Giardina, E, Packham, J, McManus, R, FitzGerald, O, McHugh, N, Brown, M A, Ho, P, Behrens, F, Burkhardt, H, Reis, A & Barton, A 2015, ' Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis. ', Nature Communications, vol. 6, 6046 . https://doi.org/10.1038/ncomms7046
Bowes, J, Budu-Aggrey, A, Huffmeier, U, Uebe, S, Steel, K, Hebert, H, Wallace, C, Massey, J, Bruce, I N, Bluett, J, Feletar, M, Morgan, A W, Marzo-Ortega, H, Donohoe, G, Morris, D W, Helliwell, P, Ryan, A W, Kane, D, Warren, R B, Korendowych, E, Alenius, G-M, Giardina, E, Packham, J, McManus, R, FitzGerald, O, McHugh, N, Brown, M A, Ho, P, Behrens, F, Burkhardt, H, Reis, A & Barton, A 2015, ' Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis. ' Nature Communications, vol. 6, 6046 . https://doi.org/10.1038/ncomms7046
Nature Communications

Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis and, despite the larger estimated heritability for PsA, the majority of genetic susceptibility loci identified to date are shared with psoriasis. Here, we present

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