Augmenting TCR signal strength and ICOS costimulation results in metabolically fit and therapeutically potent human CAR Th17 cells.

Autor: Wyatt MM; Department of Surgery: Oncology, Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA; Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA; Department of Microbiology and Immunology, Hollings Cancer Institute, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address: megan.meek.wyatt@emory.edu., Huff LW; Department of Microbiology and Immunology, Hollings Cancer Institute, Medical University of South Carolina, Charleston, SC 29425, USA., Nelson MH; Department of Microbiology and Immunology, Hollings Cancer Institute, Medical University of South Carolina, Charleston, SC 29425, USA., Neal LR; Department of Microbiology and Immunology, Hollings Cancer Institute, Medical University of South Carolina, Charleston, SC 29425, USA., Medvec AR; Department of Microbiology, Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Rangel Rivera GO; Department of Surgery: Oncology, Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA; Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA; Department of Microbiology and Immunology, Hollings Cancer Institute, Medical University of South Carolina, Charleston, SC 29425, USA., Smith AS; Department of Surgery: Oncology, Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA; Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA; Department of Microbiology and Immunology, Hollings Cancer Institute, Medical University of South Carolina, Charleston, SC 29425, USA., Rivera Reyes AM; Department of Surgery: Oncology, Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA; Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA; Department of Microbiology and Immunology, Hollings Cancer Institute, Medical University of South Carolina, Charleston, SC 29425, USA., Knochelmann HM; Department of Surgery: Oncology, Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA; Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA; Department of Microbiology and Immunology, Hollings Cancer Institute, Medical University of South Carolina, Charleston, SC 29425, USA., Riley JL; Department of Microbiology, Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Lesinski GB; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA., Paulos CM; Department of Surgery: Oncology, Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA; Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA; Department of Microbiology and Immunology, Hollings Cancer Institute, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address: cpaulos@emory.edu.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2023 Jul 05; Vol. 31 (7), pp. 2120-2131. Date of Electronic Publication: 2023 Apr 20.

Identification of human CD4 ⁺ T cell populations with distinct antitumor activity.

Autor: Nelson MH; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA.; Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, SC, USA., Knochelmann HM; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA.; Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, SC, USA., Bailey SR; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA.; Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, SC, USA., Huff LW; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA.; Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, SC, USA., Bowers JS; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA.; Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, SC, USA., Majchrzak-Kuligowska K; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA.; Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, SC, USA., Wyatt MM; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA.; Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, SC, USA., Rubinstein MP; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA.; Department of Surgery, Medical University of South Carolina, Charleston, SC, USA., Mehrotra S; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA.; Department of Surgery, Medical University of South Carolina, Charleston, SC, USA., Nishimura MI; Department of Surgery, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA., Armeson KE; Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA., Giresi PG; Epinomics, Menlo Park, CA, USA., Zilliox MJ; Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA., Broxmeyer HE; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA., Paulos CM; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA. paulos@musc.edu paulos@emory.edu.; Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, SC, USA.

Publikováno v: Science advances [Sci Adv] 2020 Jul 01; Vol. 6 (27). Date of Electronic Publication: 2020 Jul 01 (Print Publication: 2020).

Dendritic Cells in Irradiated Mice Trigger the Functional Plasticity and Antitumor Activity of Adoptively Transferred Tc17 Cells via IL12 Signaling.

Autor: Bowers JS; Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina. Department of Surgery, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina. bowersjs@musc.edu paulos@musc.edu., Nelson MH; Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina. Department of Surgery, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina., Kundimi S; Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina. Department of Surgery, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina., Bailey SR; Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina. Department of Surgery, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina., Huff LW; Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina. Department of Surgery, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina., Schwartz KM; Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina. Department of Surgery, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina., Cole DJ; Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina. Department of Surgery, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina., Rubinstein MP; Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina. Department of Surgery, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina., Paulos CM; Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina. Department of Surgery, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina. bowersjs@musc.edu paulos@musc.edu.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2015 Jun 01; Vol. 21 (11), pp. 2546-57. Date of Electronic Publication: 2015 Apr 22.

Harnessing the Microbiome to Enhance Cancer Immunotherapy.

Autor: Nelson MH; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA ; Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA., Diven MA; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA., Huff LW; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA ; Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA., Paulos CM; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA ; Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.

Publikováno v: Journal of immunology research [J Immunol Res] 2015; Vol. 2015, pp. 368736. Date of Electronic Publication: 2015 May 25.