Výsledky vyhledávání - "Huey-shin. Lin"

Reactions of 1,3-bis(2-chloroethyl)-1-nitrosourea and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in aqueous solution

Publikováno v: Journal of Medicinal Chemistry. 22:1193-1198

Products formed from the reaction of two chloroethylnitrosoureas in neutral aqueous solution have been identified and quantified. Mixture components recovered after a 1-h incubation period accounted for 75--85% of the starting nitrosourea. Approximat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392dbe7d6d6a0c92e7d262dd5262c93a
https://doi.org/10.1021/jm00196a009

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Pharmacokinetic Profile of a New Anticonvulsant, Stiripentol, in the Rhesus Monkey

Autor: René H. Levy, Huey-shin Lin

Publikováno v: Epilepsia. 24:692-702

Stiripentol is a new anticonvulsant drug derived from phenyl-l-pentene-ol. One of its metabolites resulting from opening of the methylenedioxy ring also possesses anticonvulsant activity. This study undertook to define the overall pharmacokinetic pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44eeb826b453fc3b1a8a9c31484a3859
https://doi.org/10.1111/j.1528-1157.1983.tb04632.x

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Direct reaction mixture analysis by probe insertion chemical ionization mass spectrometry

Autor: Huey-shin. Lin, R. J. Weinkam

Publikováno v: Analytical Chemistry. 51:972-975

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7bb836eaf4e7ddad027859efc59cc428
https://doi.org/10.1021/ac50043a044

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Pharmacokinetics of Stiripentol in Normal Man: Evidence of Nonlinearity

Autor: Jacques A. Tor, René H. Levy, Henri M. Blehaut, Huey-shin Lin

Publikováno v: The Journal of Clinical Pharmacology. 23:523-533

The pharmacokinetics and metabolism of stiripentol, a new antiepileptic drug, were investigated in normal male subjects after single-dose and multiple-dose administration. Each of six subjects received single doses of 300, 600, and 1200 mg of stiripe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8927a5c08f0d5e5df428b06e07a9fc15
https://doi.org/10.1002/j.1552-4604.1983.tb01799.x

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Metabolism of 1,3-bis(2-chloroethyl)-1-nitrosourea by rat hepatic microsomes

Autor: Robert J. Weinkam, Huey-Shin Lin

Publikováno v: Journal of Medicinal Chemistry. 24:761-763

The in vitro metabolism of the anticancer agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) has been studied in male Fischer 344 rat liver microsomal preparations. The previously identified product. 1,3-bis(2-chloroethyl)urea (BCU), has been shown to

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https://doi.org/10.1021/jm00138a025

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Chloroethylnitrosourea Cancer Chemotherapeutic Agents

Autor: Huey-Shin Lin, Robert J. Weinkam

Publisher Summary This chapter discusses the chloroethylnitrosourea cancer chemotherapeutic agents. Chloroethylnitrosoureas have proven to be highly effective cancer chemotherapeutic agents that are in common clinical use. Along with the developments

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b99ead3caa215f02308014981e07981a
https://doi.org/10.1016/s1054-3589(08)60019-8