Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Huey-Miin Chen"'
Autor:
Ana Nikolic, Francesca Maule, Anna Bobyn, Katrina Ellestad, Seungil Paik, Sajid A. Marhon, Parinaz Mehdipour, Xueqing Lun, Huey-Miin Chen, Claire Mallard, Alexander J. Hay, Michael J. Johnston, Christopher J. Gafuik, Franz J. Zemp, Yaoqing Shen, Nicoletta Ninkovic, Katalin Osz, Elodie Labit, N. Daniel Berger, Duncan K. Brownsey, John J. Kelly, Jeff Biernaskie, Peter B. Dirks, Darren J. Derksen, Steven J. M. Jones, Donna L. Senger, Jennifer A. Chan, Douglas J. Mahoney, Daniel D. De Carvalho, Marco Gallo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Self-renewal is a crucial property of glioblastoma cells that is enabled by the choreographed functions of chromatin regulators and transcription factors. Identifying targetable epigenetic mechanisms of self-renewal could therefore represent
Externí odkaz:
https://doaj.org/article/028fa80da48448499589471060a20e19
Autor:
Yang Yang, Biao Ma, Mahbod Djamshidi, Qingrun Zhang, Anusi Sarkar, Ayan Chanda, Uyen Tran, Jung Soh, Christina Sandall, Huey-Miin Chen, Justin A. MacDonald, Shirin Bonni, Christoph W. Sensen, Jianhua Zheng, Karl Riabowol
Publikováno v:
European Journal of Cell Biology, Vol 102, Iss 3, Pp 151341- (2023)
ING1 is a chromatin targeting subunit of the Sin3a histone deacetylase (HDAC) complex that alters chromatin structure to subsequently regulate gene expression. We find that ING1 knockdown increases expression of Twist1, Zeb 1&2, Snai1, Bmi1 and TSHZ1
Externí odkaz:
https://doaj.org/article/1436a51a89e047f3b13b738b31e903d7
Autor:
Huey-Miin Chen, Justin A. MacDonald
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101168- (2022)
Summary: Advances in high-throughput sequencing technologies now yield unprecedented volumes of OMICs data with opportunities to conduct systematic data analyses and derive novel biological insights. Here, we provide protocols to perform differential
Externí odkaz:
https://doaj.org/article/c96d77d988594482b7271778f9fe0953
Autor:
Huey-Miin Chen, Justin A. MacDonald
Publikováno v:
iScience, Vol 24, Iss 8, Pp 102831- (2021)
Summary: Colon adenocarcinoma is a prevalent malignancy with significant mortality. Hence, the identification of molecular biomarkers with prognostic significance is important for improved treatment and patient outcomes. Clinical traits and RNA-Seq o
Externí odkaz:
https://doaj.org/article/0b48a942e2ab4f3cb8f53ba943ecf846
Publikováno v:
Cancers, Vol 14, Iss 19, p 4942 (2022)
Cancer stem cells (CSCs) represent a therapy-resistant reservoir in glioblastoma (GBM). It is now becoming clear that epigenetic and chromatin remodelling programs link the stemlike behaviour of CSCs to their treatment resistance. New evidence indica
Externí odkaz:
https://doaj.org/article/b2179991a20147b6843302b28001d82b
Autor:
Jaye M. Platnich, Hyunjae Chung, Arthur Lau, Christina F. Sandall, Adom Bondzi-Simpson, Huey-Miin Chen, Takanori Komada, Aaron C. Trotman-Grant, Jeremy R. Brandelli, Justin Chun, Paul L. Beck, Dana J. Philpott, Stephen E. Girardin, May Ho, Roger P. Johnson, Justin A. MacDonald, Glen D. Armstrong, Daniel A. Muruve
Publikováno v:
Cell Reports, Vol 25, Iss 6, Pp 1525-1536.e7 (2018)
Summary: The non-canonical caspase-4 and canonical NLRP3 inflammasomes are both activated by intracellular lipopolysaccharide (LPS), but the crosstalk between these two pathways remains unclear. Shiga toxin 2 (Stx2)/LPS complex, from pathogenic enter
Externí odkaz:
https://doaj.org/article/b1fc8d30a7c34e8d876e21e962d781d8
Various signaling molecules affecting epithelial restitution and wound healing are dysregulated in ulcerative colitis. Recent evidence demonstrates the necessity of Hippo-YAP/TAZ signaling, interceded by cytoskeletal remodeling, for intestinal regene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23c6ba11bcc40c223a0ae719d2f8f6a4
https://doi.org/10.1101/2021.12.03.471118
https://doi.org/10.1101/2021.12.03.471118
Autor:
Justin MacDonald, Tina Huey-Miin Chen
Publikováno v:
Inflamm Bowel Dis
Background Ulcerative colitis (UC) is a progressive disorder that elevates the risk of colon cancer development through a colitis-dysplasia-carcinoma sequence. Gene expression profiling of colitis-associated lesions obtained from patients with varied
Autor:
Justin A. MacDonald, Huey-Miin Chen
Ulcerative colitis (UC) is a progressive disorder that elevates the risk of cancer development through a colitis-dysplasia-carcinoma sequence. Differential gene expression (DEGs) profiles of three UC clinical subtypes and healthy controls were develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86aee432f883c5245e745afb2eb5ee98
https://doi.org/10.1101/2021.09.21.21263916
https://doi.org/10.1101/2021.09.21.21263916
Autor:
Stephen E. Girardin, Takanori Komada, Justin A. MacDonald, Huey-Miin Chen, Daniel A. Muruve, Paul L. Beck, Roger P. Johnson, Jaye M. Platnich, Adom Bondzi-Simpson, Jeremy R. Brandelli, Arthur Lau, Aaron Trotman-Grant, Hyunjae Chung, Christina F. Sandall, Glen D. Armstrong, Justin Chun, Dana J. Philpott, May Ho
Publikováno v:
Cell Reports, Vol 25, Iss 6, Pp 1525-1536.e7 (2018)
Summary: The non-canonical caspase-4 and canonical NLRP3 inflammasomes are both activated by intracellular lipopolysaccharide (LPS), but the crosstalk between these two pathways remains unclear. Shiga toxin 2 (Stx2)/LPS complex, from pathogenic enter