Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Huey-Jen L. Lin"'
Autor:
Michael W.Y. Chan, Yi-Wen Huang, Corinna Hartman-Frey, Chieh-Ti Kuo, Daniel Deatherage, Huaxia Qin, Alfred S.L. Cheng, Pearlly S. Yan, Ramana V. Davuluri, Tim H.-M. Huang, Kenneth P. Nephew, Huey-Jen L. Lin
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 9, Pp 908-919 (2008)
Transforming growth factor-beta (TGF-β)/SMAD signaling is a key growth regulatory pathway often dysregulated in ovarian cancer and other malignancies. Although loss of TGF-β–mediated growth inhibition has been shown to contribute to aberrant cell
Externí odkaz:
https://doaj.org/article/5c810bd16a6a4a22bc50b38b4ba93cf7
Autor:
Tim H.-M. Huang, Victor X. Jin, Alfred S. L. Cheng, Huey-Jen L. Lin, Charles L. Shapiro, Bhuvaneswari Ramaswamy, Cenny Taslim, Pei-Yin Hsu, Daniel E. Deatherage, Sandya Liyanarachchi, Yi-Wen Huang, Fei Gu, Rulong Shen, Yu-I Weng, Xun Lan, Ta-Ming Liu, Tao Zuo
Supplementary Figures 1-6, Tables 1-15, Methods from Epigenetic Silencing Mediated through Activated PI3K/AKT Signaling in Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90c8740a2ba20bff2c5a97e0c3e92c4
https://doi.org/10.1158/0008-5472.22389515.v1
https://doi.org/10.1158/0008-5472.22389515.v1
Autor:
Tim H.-M. Huang, Michael C. Ostrowski, Ann-Lii Cheng, Pearlly S. Yan, Shili Lin, Lisa Asamoto, Dustin Potter, Daniel E. Deatherage, Rulong Shen, Shuying Sun, Sandya Liyanarachchi, Chieh Ti Kuo, Ching-Hung Lin, Tao Zuo, Huey-Jen L. Lin
The interplay between histone modifications and promoter hypermethylation provides a causative explanation for epigenetic gene silencing in cancer. Less is known about the upstream initiators that direct this process. Here, we report that the Cystati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e14c6175872de36c362df21320510646
https://doi.org/10.1158/0008-5472.c.6497111
https://doi.org/10.1158/0008-5472.c.6497111
Autor:
Tim H.-M. Huang, Michael C. Ostrowski, Ann-Lii Cheng, Pearlly S. Yan, Shili Lin, Lisa Asamoto, Dustin Potter, Daniel E. Deatherage, Rulong Shen, Shuying Sun, Sandya Liyanarachchi, Chieh Ti Kuo, Ching-Hung Lin, Tao Zuo, Huey-Jen L. Lin
Supplementary Methods, Figures 1-5, Tables 1-5 from Breast Cancer–Associated Fibroblasts Confer AKT1-Mediated Epigenetic Silencing of Cystatin M in Epithelial Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c2297b6d1305443dcb8462531c3471f
https://doi.org/10.1158/0008-5472.22373507
https://doi.org/10.1158/0008-5472.22373507
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36891 (2012)
The cis-acting promoter element responsible for epigenetic silencing of retinoic acid receptor responder 1 (RARRES1) by methylation is unclear. Likewise, how aberrant methylation interplays effectors and thus affects breast neoplastic features remain
Externí odkaz:
https://doaj.org/article/6264257b7fd64263bcbaf7c93717c0cb
Autor:
Ying-Wei Li, Matthew T. Zuzolo, Huey-Jen L. Lin, Michael W.Y. Chan, Jennifer Chao Weber, Zhengang Peng
Publikováno v:
Toxicology and Epigenetics
Publikováno v:
Cancer Research. 71:7226-7237
STAT3 is constitutively activated in colon cancer but its contributions in cancer-initiating cells have not been explored. In this study, we characterized STAT3 in aldehyde dehydrogenase (ALDH)-positive (ALDH+) and CD133-positive (CD133+) subpopulati
Autor:
Daniel E. Deatherage, Xun Lan, Tao Zuo, Victor X. Jin, Ta-Ming Liu, Huey Jen L Lin, Rulong Shen, Charles L. Shapiro, Bhuvaneswari Ramaswamy, Cenny Taslim, Fei Gu, Pei Yin Hsu, Yi-Wen Huang, Sandya Liyanarachchi, Yu I. Weng, Alfred S. L. Cheng, Tim H M Huang
Publikováno v:
Cancer Research. 71:1752-1762
Trimethylation of histone 3 lysine 27 (H3K27me3) is a critical epigenetic mark for the maintenance of gene silencing. Additional accumulation of DNA methylation in target loci is thought to cooperatively support this epigenetic silencing during tumor
Autor:
Jian Liang Chou, Michael W.Y. Chan, Tai Kuang Chao, Yu Ping Liao, Chieh Ti Kuo, Yi Hui Lai, Lin Yu Chen, Tim H M Huang, Yi-Wen Huang, Shu-Huei Hsiao, Pearlly S. Yan, Chien-Kuo Tai, Ramana V. Davuluri, Her Young Su, Hung Cheng Lai, Corinna Hartman-Frey, Daniel E. Deatherage, Hui Wen Yang, Kenneth P. Nephew, Huey Jen L Lin
Publikováno v:
Laboratory Investigation. 90:414-425
Resistance to TGF-beta is frequently observed in ovarian cancer, and disrupted TGF-beta/SMAD4 signaling results in the aberrant expression of downstream target genes in the disease. Our previous study showed that ADAM19, a SMAD4 target gene, is downr
Autor:
Zhengang Peng, Tao Zuo, Sonya S. Yamashita, Jennifer R. Chao, Tim H M Huang, Huey Jen L Lin, Lisa K. Asamoto
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1790:920-924
It is becoming increasingly evident that discrete genetic alterations in neoplastic cells alone cannot explain multistep carcinogenesis whereby tumor cells are able to express diverse phenotypes during the complex phases of tumor development and prog