Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Huey Jin Lim"'
Autor:
Kenon Chua, Arthur Yi Loong Sim, Eric Yew Meng Yeo, Muhammad Sufyan Bin Masroni, Wah Wah Naw, Sai Mun Leong, Kee Wah Lee, Huey Jin Lim, David M. Virshup, Victor Kwan Min Lee
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4759 (2023)
There is an increasing urgency in the search for new drugs to target high-grade cancers such as osteosarcomas (OS), as these have limited therapeutic options and poor prognostic outlook. Even though key molecular events leading to tumorigenesis are n
Externí odkaz:
https://doaj.org/article/53adbe271dd349ecaaa9c5fe02765a9b
Autor:
Ananya Pal, Jia Yu Leung, Gareth Chin Khye Ang, Vinay Kumar Rao, Luca Pignata, Huey Jin Lim, Maxime Hebrard, Kenneth TE Chang, Victor KM Lee, Ernesto Guccione, Reshma Taneja
Publikováno v:
eLife, Vol 9 (2020)
Wnt signaling is downregulated in embryonal rhabdomyosarcoma (ERMS) and contributes to the block of differentiation. Epigenetic mechanisms leading to its suppression are unknown and could pave the way toward novel therapeutic modalities. We demonstra
Externí odkaz:
https://doaj.org/article/db70951a46d04ec4b8dcef9cb836464b
Autor:
H. Phillip Koeffler, Jeffrey W. Tyner, Charles Forscher, Anand Mayakonda, Marilynn Chow, Sigal Gery, Jonathan W. Said, Ngan Doan, Huey Jin Lim, Victor Kwan Min Lee, David D. Gae, Brendan Pang, Qi Cao, De-Chen Lin, Haibo Sun
Fig. S1. GSEA analysis revealed significant enrichment of gene associated with genomic unstable EWS phenotype (A), cell cycle (B) and NF-κB (C) in SYK knockdown cells, and gene associated with metastasis (D) in cells treated with the SYK inhibitor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab0ab41a53fa1084607efb20ad68eda
https://doi.org/10.1158/1078-0432.22468367.v1
https://doi.org/10.1158/1078-0432.22468367.v1
Autor:
H. Phillip Koeffler, Jeffrey W. Tyner, Charles Forscher, Anand Mayakonda, Marilynn Chow, Sigal Gery, Jonathan W. Said, Ngan Doan, Huey Jin Lim, Victor Kwan Min Lee, David D. Gae, Brendan Pang, Qi Cao, De-Chen Lin, Haibo Sun
Purpose: Ewing sarcoma (EWS) is a devastating soft tissue sarcoma affecting predominantly young individuals. Tyrosine kinases (TK) and associated pathways are continuously activated in many malignancies, including EWS; these enzymes provide candidate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93a0334472e77b8fec3e8e16dd0de64
https://doi.org/10.1158/1078-0432.c.6526913.v1
https://doi.org/10.1158/1078-0432.c.6526913.v1
Autor:
Reshma Taneja, Ernesto Guccione, Victor K. Lee, Kenneth T. Chang, Sudha Suriyamurthy, Huey Jin Lim, Luca Pignata, Vinay Kumar Rao, Monica Palanichamy Kala, Akshay V. Bhat
Alveolar rhabdomyosarcoma (ARMS) is an aggressive pediatric cancer with poor prognosis. As transient and stable modifications to chromatin have emerged as critical mechanisms in oncogenic signaling, efforts to target epigenetic modifiers as a therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50b5099c1fb7e2aa06ef53d21bf9f2c1
https://doi.org/10.1158/0008-5472.c.6511646.v1
https://doi.org/10.1158/0008-5472.c.6511646.v1
Autor:
Reshma Taneja, Ernesto Guccione, Victor K. Lee, Kenneth T. Chang, Sudha Suriyamurthy, Huey Jin Lim, Luca Pignata, Vinay Kumar Rao, Monica Palanichamy Kala, Akshay V. Bhat
Supplementary Figure S1. Inhibition of G9a activity reduces colony formation. Supplementary Figure S2. Inhibition of G9a expression or activity in RH30 cells impacts proliferation, differentiation and motility Supplementary Figure S3. Inhibition of G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff7b5da59bbfa505579f76c3e1d3cf5
https://doi.org/10.1158/0008-5472.22423997
https://doi.org/10.1158/0008-5472.22423997
Autor:
H. Phillip Koeffler, Jeffrey W. Tyner, Charles Forscher, Anand Mayakonda, Marilynn Chow, Sigal Gery, Jonathan W. Said, Ngan Doan, Huey Jin Lim, Victor Kwan Min Lee, David D. Gae, Brendan Pang, Qi Cao, De-Chen Lin, Haibo Sun
Table S1. Small molecule inhibitors. Listing of all 116 agents on the screening inhibitor panel with respective molecular targets and sources Table S2. Primers for QRT-PCR and plasmid construction. Table S3. IC50s of 116 small molecule inhibitors in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7e8a15d385eb203e9e624030f8226f
https://doi.org/10.1158/1078-0432.22468361
https://doi.org/10.1158/1078-0432.22468361
Autor:
H. Phillip Koeffler, Raja Rajalingam, Sharon Shacham, Erkan Baloglu, Charles Forscher, Tom Thomas, Anand Mayakonda, Peiguo Chu, Jonathan W. Said, Ngan Doan, Huey Jin Lim, Victor Kwan Min Lee, Brendan Pang, Henry Yang, Liang Xu, Sigal Gery, Zhiqiang Zhao, Helene Marijon, Xiao Guo, Qi Cao, De-Chen Lin, Haibo Sun
Ewing sarcoma (EWS) is an aggressive bone malignancy that mainly affects children and young adults. The mechanisms by which EWS (EWSR1) fusion genes drive the disease are not fully understood. CRM1 (XPO1) traffics proteins from the nucleus, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a68a15b58b4fef850f1829b4b26714e
https://doi.org/10.1158/0008-5472.c.6507743.v1
https://doi.org/10.1158/0008-5472.c.6507743.v1
Autor:
H. Phillip Koeffler, Raja Rajalingam, Sharon Shacham, Erkan Baloglu, Charles Forscher, Tom Thomas, Anand Mayakonda, Peiguo Chu, Jonathan W. Said, Ngan Doan, Huey Jin Lim, Victor Kwan Min Lee, Brendan Pang, Henry Yang, Liang Xu, Sigal Gery, Zhiqiang Zhao, Helene Marijon, Xiao Guo, Qi Cao, De-Chen Lin, Haibo Sun
Figure legends for supplemental figures S1-S6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6af682032d618aa2e65f089068a5a7
https://doi.org/10.1158/0008-5472.22409276.v1
https://doi.org/10.1158/0008-5472.22409276.v1
Autor:
H. Phillip Koeffler, Raja Rajalingam, Sharon Shacham, Erkan Baloglu, Charles Forscher, Tom Thomas, Anand Mayakonda, Peiguo Chu, Jonathan W. Said, Ngan Doan, Huey Jin Lim, Victor Kwan Min Lee, Brendan Pang, Henry Yang, Liang Xu, Sigal Gery, Zhiqiang Zhao, Helene Marijon, Xiao Guo, Qi Cao, De-Chen Lin, Haibo Sun
Table S1. qRT-PCR primers. Table S2. CRM1 expression among different cancer types patient sample tissues. Table S3. CRM1 Expression among different cancer types ( cancer cell lines from CCLE database). Table S4. patients clinical infomation and h sco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fdd084af61a97bf793e984b1b25eec3
https://doi.org/10.1158/0008-5472.22409270
https://doi.org/10.1158/0008-5472.22409270