Výsledky vyhledávání - "Huey Fen Chiu"

Cytotoxicities and Topoisomerase I Inhibitory Activities of 2-[2-(2-Alkynylphenyl)ethynyl]benzonitriles, 1-Aryldec-3-ene-1,5-diynes, and Related Bis(enediynyl)arene Compounds

Autor: Chi-Fong Lin, Pei-Chen Hsieh, Chyi-Jia Wang, Huey-Fen Chiu, Wen-Der Lu, Yao-Haur Kuo, Ming-Jung Wu

Publikováno v: Helvetica Chimica Acta. 85:2564-2575

The activities of a series of acyclic enediynes, 2-(6-substituted hex-3-ene-1,5-diynyl)benzonitriles (1–5) and their derivatives 7–23 were evaluated against several solid tumor cell lines and topoisomerase I. Compounds 1–5 show selective cytoto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82410bbf4696b3fdde80595c7de5bc4b
https://doi.org/10.1002/1522-2675(200208)85:8<2564::aid-hlca2564>3.0.co

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A Series of Enediynes as Novel Inhibitors of Topoisomerase I

Autor: Huey-Fen Chiu, Chi-Fong Lin, Ming-Jung Wu, Wen-Der Lu, Pei-Chen Hsieh

Publikováno v: Bioorganic & Medicinal Chemistry. 9:1707-1711

A series of acyclic enediynes, 2-((6-substituted)-3-hexen-1,5-diynyl)benzonitriles (8--11), display potent inhibition against topoisomerase I without the formation of active biradical intermediates and show inhibitory activity against topoisomerase I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c869b308a4b237d0242a4cc259dc9b33
https://doi.org/10.1016/s0968-0896(01)00081-5

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Synthesis of (15S,16S,21R)-4-deoxyrollicosin analog

Autor: Ming-Jung Wu, Ling Yu Hsieh, Huey Fen Chiu, Wan Ru Lin, Chi Fong Lin, Jeng Lin Lee, Yang Chang Wu, Kun Sheng Wang

Publikováno v: Tetrahedron Letters. 44:7833-7835

Synthesis of 4-deoxy rollicosin analog 2 was completed in nine steps, which was based on palladium-catalyzed coupling of two building blocks 3 and 4 . Lactone 3 was synthesized from 5-hexyn-1-ol, and vinyl iodide 4 was accessed from l -glutamate and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f647c57c59385bf3682f361bc11a57ed
https://doi.org/10.1016/j.tetlet.2003.08.088

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ChemInform Abstract: Synthesis of a Hydroxylated Muricatacin Analogue Related to Squamocin

Autor: Ming-Jung Wu, Li-Lan Wei, Huey-Fen Chiu, Pei‐Chen Hsieh, Yang Chang Wu, Shih‐Hung Tsai

Publikováno v: ChemInform. 30

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::487eca4a2b953daef668098b6d841515
https://doi.org/10.1002/chin.199923295

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The alkaloids of Artabotrys uncinatus

Autor: Yi-Chen Chia, Yang-Chang Wu, Fang Rong Chang, Tian-Jye Hsieh, Chung Yi Chen, Hang-Ching Lin, Huey-Fen Chiu

Publikováno v: Journal of natural products. 64(9)

A novel type of alpha,beta-butenolide alkaloid, uncinine (1), two novel oxoaporphines, artabonatine C (2) and artabonatine D (3), a new oxazoloaporphine, artabonatine E (4), and a new 7,7'-bisdehydroaporphine, artabonatine F (5), along with 25 known

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148ec3f5b6e98fd9abe182133b01fba0
https://pubmed.ncbi.nlm.nih.gov/11575948

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Synthesis of a hydroxylated muricatacin analog related to squamocin

Autor: Huey Fen Chiu, Shih Hung Tsai, Ming-Jung Wu, Yang Chang Wu, Pei Chen Hsieh, Li Lan Wei

Publikováno v: Tetrahedron Letters. 40:1975-1976

Compound 1 was synthesized in 9 steps and 5.5% overall yield from heptanal. The IC 50 of compound 1 against the growth of human hepatocarcinoma cell lines (Hep G 2 and 2,2,15) are 22.0 and 21.8 μM, respectively.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b8fbc42313a86f7dbd9e12a71d131bd
https://doi.org/10.1016/s0040-4039(99)00127-6

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