Radiographic endophenotyping in hip osteoarthritis improves the precision of genetic association analysis

Autor: Panoutsopoulou, K., Thiagarajah, S., Zengini, E., Day-Williams, A.G., Ramos, Y.F.M., Meessen, J.M.T.A., Huetink, K., Nelissen, R.G.H.H., Southam, L., Rayner, N.W., Doherty, M., Meulenbelt, I., Zeggini, E., Wilkinson, J.M., ArcOGEN Consortium

Publikováno v: Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases, 76(7), 1199-1206

OBJECTIVE: Osteoarthritis (OA) has a strong genetic component but the success of previous genome-wide association studies (GWAS) has been restricted due to insufficient sample sizes and phenotype heterogeneity. Our aim was to examine the effect of cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7aef8195c907c7a902932eeb2530b147
https://hdl.handle.net/1887/114534

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Radiographic endophenotyping in hip osteoarthritis improves the precision of genetic association analysis.

Autor: Panoutsopoulou K; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK., Thiagarajah S; Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK., Zengini E; Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.; 5th Psychiatric Department, Dromokaiteio Psychiatric Hospital of Athens, Athens, Greece., Day-Williams AG; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.; Department of Genomics and Computational Biology, Biogen Idec, Cambridge, Massachusetts, USA., Ramos YF; Department of Molecular Epidemiology, LUMC, Leiden, The Netherlands., Meessen JM; Department of Molecular Epidemiology, LUMC, Leiden, The Netherlands.; Department of Orthopaedics, LUMC, Leiden, The Netherlands., Huetink K; Department of Orthopaedics, LUMC, Leiden, The Netherlands., Nelissen RG; Department of Orthopaedics, LUMC, Leiden, The Netherlands., Southam L; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.; Wellcome Trust Centre for Human Genetics, Oxford, UK., Rayner NW; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.; Wellcome Trust Centre for Human Genetics, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Doherty M; Academic Rheumatology, University of Nottingham, Nottingham, UK., Meulenbelt I; Department of Molecular Epidemiology, LUMC, Leiden, The Netherlands., Zeggini E; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK., Wilkinson JM; Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.

Publikováno v: Annals of the rheumatic diseases [Ann Rheum Dis] 2017 Jul; Vol. 76 (7), pp. 1199-1206. Date of Electronic Publication: 2016 Dec 14.