Moderate exercise protects against joint disease in a murine model of osteoarthritis

Autor: Huesa, C., Dunning, L., MacDougall, K., Fegen, M., Ortiz, A., McCulloch, K., McGrath, S., Litherland, G. J., Crilly, A., Van ‘T Hof, R. J., Ferrell, W. R., Goodyear, C. S., Lockhart, J. C.

Publikováno v: Frontiers in physiology. 13

Exercise is recommended as a non-pharmacological therapy for osteoarthritis (OA). Various exercise regimes, with differing intensities and duration, have been used in a range of OA rodent models. These studies show gentle or moderate exercise reduces

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cefdcd7ef00578634b36863a8baffeeb
https://pubmed.ncbi.nlm.nih.gov/36545287

New insights into NPP1 function: Lessons from clinical and animal studies

Autor: Mackenzie, N.C.W., Huesa, C., Rutsch, F., MacRae, V.E.

Publikováno v: In Bone November 2012 51(5):961-968

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Mechanical stimulation of bone cells using fluid flow

Autor: Huesa, C., Bakker, A.D., Helfrich, M.H., Ralston, S.H.

Publikováno v: Bone Research Protocols, 573-592
ISSUE=2nd;STARTPAGE=573;ENDPAGE=592;TITLE=Bone Research Protocols
Methods in Molecular Biology ISBN: 9781617794148

This chapter describes several methods suitable for mechanically stimulating monolayers of bone cells by fluid shear stress (FSS) in vitro. Fluid flow is generated by pumping culture medium through two parallel plates, one of which contains a monolay

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb9251c6493a69a363513cb33bad3f1
https://doi.org/10.1007/978-1-61779-415-5_36

Direct stimulation of bone mass by increased GH signalling in the osteoblasts of Socs2(-/-) mice

Autor: Dobie, R., MacRae, V.E., Huesa, C., van't Hof, R., Ahmed, S.F., Farquharson, C.

Publikováno v: JOURNAL OF ENDOCRINOLOGY

The suppressor of cytokine signalling (Socs2−/−)-knockout mouse is characterised by an overgrowth phenotype due to enhanced GH signalling. The objective of this study was to define the Socs2−/− bone phenotype and determine whether GH promotes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6f3e2abf1cb6254efd16df7e0fbb624b