The target landscape of clinical kinase drugs.

Autor: Klaeger S; Chair of Proteomics and Bioanalytics, Technical University of Munich (TUM), Freising, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Heinzlmeir S; Chair of Proteomics and Bioanalytics, Technical University of Munich (TUM), Freising, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Wilhelm M; Chair of Proteomics and Bioanalytics, Technical University of Munich (TUM), Freising, Germany., Polzer H; German Cancer Consortium (DKTK), Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Internal Medicine III, University Hospital, Ludwig-Maximilians-Universität (LMU) München, Munich, Germany., Vick B; German Cancer Consortium (DKTK), Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, German Center for Environmental Health (HMGU), Munich, Germany., Koenig PA; Institut für Klinische Chemie und Pathobiochemie, TUM, Munich, Germany., Reinecke M; Chair of Proteomics and Bioanalytics, Technical University of Munich (TUM), Freising, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Ruprecht B; Chair of Proteomics and Bioanalytics, Technical University of Munich (TUM), Freising, Germany., Petzoldt S; Chair of Proteomics and Bioanalytics, Technical University of Munich (TUM), Freising, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Meng C; Chair of Proteomics and Bioanalytics, Technical University of Munich (TUM), Freising, Germany., Zecha J; Chair of Proteomics and Bioanalytics, Technical University of Munich (TUM), Freising, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Reiter K; German Cancer Consortium (DKTK), Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Internal Medicine III, University Hospital, Ludwig-Maximilians-Universität (LMU) München, Munich, Germany., Qiao H; Chair of Proteomics and Bioanalytics, Technical University of Munich (TUM), Freising, Germany., Helm D; Chair of Proteomics and Bioanalytics, Technical University of Munich (TUM), Freising, Germany., Koch H; Chair of Proteomics and Bioanalytics, Technical University of Munich (TUM), Freising, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Schoof M; Chair of Proteomics and Bioanalytics, Technical University of Munich (TUM), Freising, Germany., Canevari G; Oncology, Nerviano Medical Sciences Srl, Milan, Italy., Casale E; Oncology, Nerviano Medical Sciences Srl, Milan, Italy., Depaolini SR; Oncology, Nerviano Medical Sciences Srl, Milan, Italy., Feuchtinger A; Research Unit Analytical Pathology, Helmholtz Zentrum München, Neuherberg, Germany., Wu Z; Chair of Proteomics and Bioanalytics, Technical University of Munich (TUM), Freising, Germany., Schmidt T; Chair of Proteomics and Bioanalytics, Technical University of Munich (TUM), Freising, Germany., Rueckert L; SAP SE, Potsdam, Germany., Becker W; SAP SE, Potsdam, Germany., Huenges J; SAP SE, Potsdam, Germany., Garz AK; German Cancer Consortium (DKTK), Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Medicine III, Klinikum rechts der Isar, TUM, Munich, Germany., Gohlke BO; German Cancer Consortium (DKTK), Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Structural Bioinformatics Group, Charité-Universitätsmedizin, Berlin, Germany., Zolg DP; Chair of Proteomics and Bioanalytics, Technical University of Munich (TUM), Freising, Germany., Kayser G; Institute of Surgical Pathology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Vooder T; Center of Thoracic Surgery, Krefeld, Germany.; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Tartu University Hospital, Tartu, Estonia., Preissner R; German Cancer Consortium (DKTK), Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Structural Bioinformatics Group, Charité-Universitätsmedizin, Berlin, Germany., Hahne H; Chair of Proteomics and Bioanalytics, Technical University of Munich (TUM), Freising, Germany., Tõnisson N; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Tartu University Hospital, Tartu, Estonia., Kramer K; Chair of Proteomics and Bioanalytics, Technical University of Munich (TUM), Freising, Germany., Götze K; German Cancer Consortium (DKTK), Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Medicine III, Klinikum rechts der Isar, TUM, Munich, Germany., Bassermann F; German Cancer Consortium (DKTK), Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Medicine III, Klinikum rechts der Isar, TUM, Munich, Germany., Schlegl J; SAP SE, Walldorf, Germany., Ehrlich HC; SAP SE, Potsdam, Germany., Aiche S; SAP SE, Potsdam, Germany., Walch A; Research Unit Analytical Pathology, Helmholtz Zentrum München, Neuherberg, Germany., Greif PA; German Cancer Consortium (DKTK), Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Internal Medicine III, University Hospital, Ludwig-Maximilians-Universität (LMU) München, Munich, Germany., Schneider S; Department of Chemistry, TUM, Garching, Germany.; Center For Integrated Protein Science Munich (CIPSM), Munich, Germany., Felder ER; Oncology, Nerviano Medical Sciences Srl, Milan, Italy., Ruland J; German Cancer Consortium (DKTK), Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Institut für Klinische Chemie und Pathobiochemie, TUM, Munich, Germany., Médard G; Chair of Proteomics and Bioanalytics, Technical University of Munich (TUM), Freising, Germany., Jeremias I; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, German Center for Environmental Health (HMGU), Munich, Germany.; Department of Pediatrics, Dr von Hauner Children's Hospital, LMU, Munich, Germany., Spiekermann K; German Cancer Consortium (DKTK), Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Internal Medicine III, University Hospital, Ludwig-Maximilians-Universität (LMU) München, Munich, Germany., Kuster B; Chair of Proteomics and Bioanalytics, Technical University of Munich (TUM), Freising, Germany. kuster@tum.de.; German Cancer Consortium (DKTK), Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Center For Integrated Protein Science Munich (CIPSM), Munich, Germany.; Bavarian Biomolecular Mass Spectrometry Center (BayBioMS), TUM, Freising, Germany.

Publikováno v: Science (New York, N.Y.) [Science] 2017 Dec 01; Vol. 358 (6367).

Leucettinib-21, a DYRK1A Kinase Inhibitor as Clinical Drug Candidate for Alzheimer's Disease and Down Syndrome.

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Impact of soil model complexity on the long-term thermal performance prediction of a new shallow bore ground heat exchanger.

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Autor: Joisa, Chinmaya U., Chen, Kevin A., Berginski, Matthew E., Golitz, Brian T., Jenner, Madison R., Loeza, Gabriela Herrera, Jen Jen Yeh, Gomez, Shawn M.

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