MERTK inhibition selectively activates a DC - T-cell axis to provide anti-leukemia immunity.

Autor: Huelse JM; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Department of Pediatrics, Emory University, Atlanta, GA, 30322, USA., Bhasin SS; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Department of Pediatrics, Emory University, Atlanta, GA, 30322, USA., Jacobsen KM; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Department of Pediatrics, Emory University, Atlanta, GA, 30322, USA., Yim J; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Department of Pediatrics, Emory University, Atlanta, GA, 30322, USA., Thomas BE; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Department of Pediatrics, Emory University, Atlanta, GA, 30322, USA., Branella GM; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Department of Pediatrics, Emory University, Atlanta, GA, 30322, USA., Bakhtiari M; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Department of Pediatrics, Emory University, Atlanta, GA, 30322, USA., Chimenti ML; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Department of Pediatrics, Emory University, Atlanta, GA, 30322, USA., Baxter TA; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Department of Pediatrics, Emory University, Atlanta, GA, 30322, USA., Raikar SS; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Department of Pediatrics, Emory University, Atlanta, GA, 30322, USA., Wang X; Center for Integrative Chemical Biology and Drug Discovery and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.; UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC, 27599, USA., Frye SV; Center for Integrative Chemical Biology and Drug Discovery and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.; UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC, 27599, USA., Henry CJ; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Department of Pediatrics, Emory University, Atlanta, GA, 30322, USA.; Department of Immunology and Microbiology, The University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA., Earp HS; UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC, 27599, USA.; Departments of Medicine and Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Bhasin M; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Department of Pediatrics, Emory University, Atlanta, GA, 30322, USA.; Cancer Immunology Program, Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.; Wallace H Coulter Department of Biomedical Engineering, Emory University and Georgia Tech, Atlanta, GA, 30322, USA., DeRyckere D; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Department of Pediatrics, Emory University, Atlanta, GA, 30322, USA., Graham DK; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Department of Pediatrics, Emory University, Atlanta, GA, 30322, USA. douglas.graham@choa.org.

Publikováno v: Leukemia [Leukemia] 2024 Sep 25. Date of Electronic Publication: 2024 Sep 25.

TAM family kinases as therapeutic targets at the interface of cancer and immunity.

Autor: DeRyckere D; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA.; Department of Paediatrics, Emory University School of Medicine, Atlanta, GA, USA., Huelse JM; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA.; Department of Paediatrics, Emory University School of Medicine, Atlanta, GA, USA., Earp HS; Department of Medicine, UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA.; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Graham DK; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA. douglas.graham@choa.org.; Department of Paediatrics, Emory University School of Medicine, Atlanta, GA, USA. douglas.graham@choa.org.

Publikováno v: Nature reviews. Clinical oncology [Nat Rev Clin Oncol] 2023 Nov; Vol. 20 (11), pp. 755-779. Date of Electronic Publication: 2023 Sep 04.

Corrigendum to "MERTK in cancer therapy: Targeting the receptor tyrosine kinase in tumor cells and the immune system" [Pharmacology & Therapeutics 213 (2020) 107577].

Autor: Huelse JM; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Department of Pediatrics, Emory University, Atlanta, GA, USA., Fridlyand DM; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Department of Pediatrics, Emory University, Atlanta, GA, USA., Earp S; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA., DeRyckere D; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Department of Pediatrics, Emory University, Atlanta, GA, USA., Graham DK; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Department of Pediatrics, Emory University, Atlanta, GA, USA. Electronic address: Douglas.Graham@choa.org.

Publikováno v: Pharmacology & therapeutics [Pharmacol Ther] 2021 Sep; Vol. 225, pp. 107822. Date of Electronic Publication: 2021 Mar 10.

Data-Driven Construction of Antitumor Agents with Controlled Polypharmacology.

Autor: Da C; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599-7363 , United States., Zhang D; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599-7363 , United States., Stashko M; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599-7363 , United States., Vasileiadi E; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, and Department of Pediatrics , Emory University , Atlanta , Georgia 30322 , United States., Parker RE; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, and Department of Pediatrics , Emory University , Atlanta , Georgia 30322 , United States., Minson KA; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, and Department of Pediatrics , Emory University , Atlanta , Georgia 30322 , United States., Huey MG; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, and Department of Pediatrics , Emory University , Atlanta , Georgia 30322 , United States., Huelse JM; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, and Department of Pediatrics , Emory University , Atlanta , Georgia 30322 , United States., Hunter D, Gilbert TSK, Norris-Drouin J; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599-7363 , United States., Miley M, Herring LE, Graves LM, DeRyckere D; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, and Department of Pediatrics , Emory University , Atlanta , Georgia 30322 , United States., Earp HS, Graham DK; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, and Department of Pediatrics , Emory University , Atlanta , Georgia 30322 , United States., Frye SV; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599-7363 , United States., Wang X; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599-7363 , United States., Kireev D; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599-7363 , United States.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2019 Oct 02; Vol. 141 (39), pp. 15700-15709. Date of Electronic Publication: 2019 Sep 20.