Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Hue N. T. Tran"'
Autor:
Sina Jami, Jennifer R. Deuis, Tabea Klasfauseweh, Xiaoyang Cheng, Sergey Kurdyukov, Felicity Chung, Andrei L. Okorokov, Shengnan Li, Jiangtao Zhang, Ben Cristofori-Armstrong, Mathilde R. Israel, Robert J. Ju, Samuel D. Robinson, Peng Zhao, Lotten Ragnarsson, Åsa Andersson, Poanna Tran, Vanessa Schendel, Kirsten L. McMahon, Hue N. T. Tran, Yanni K.-Y. Chin, Yifei Zhu, Junyu Liu, Theo Crawford, Saipriyaa Purushothamvasan, Abdella M. Habib, David A. Andersson, Lachlan D. Rash, John N. Wood, Jing Zhao, Samantha J. Stehbens, Mehdi Mobli, Andreas Leffler, Daohua Jiang, James J. Cox, Stephen G. Waxman, Sulayman D. Dib-Hajj, G. Gregory Neely, Thomas Durek, Irina Vetter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Voltage-gated sodium (NaV) channels are critical regulators of neuronal excitability and are targeted by many toxins that directly interact with the pore-forming α subunit, typically via extracellular loops of the voltage-sensing domains, o
Externí odkaz:
https://doaj.org/article/ef7fee6301d340c5b67edc494cc4b801
Autor:
Kirsten L. McMahon, Hue N. T. Tran, Jennifer R. Deuis, David J. Craik, Irina Vetter, Christina I. Schroeder
Publikováno v:
Toxins, Vol 14, Iss 9, p 600 (2022)
µ-Conotoxins are small, potent, peptide voltage-gated sodium (NaV) channel inhibitors characterised by a conserved cysteine framework. Despite promising in vivo studies indicating analgesic potential of these compounds, selectivity towards the thera
Externí odkaz:
https://doaj.org/article/284b70228f8842f0997a55259521fe7b
Autor:
Alican Gulsevin, Roger L. Papke, Clare Stokes, Hue N. T. Tran, Aihua H. Jin, Irina Vetter, Jens Meiler
Publikováno v:
Toxins, Vol 13, Iss 8, p 555 (2021)
α-conotoxins are 13–19 amino acid toxin peptides that bind various nicotinic acetylcholine receptor (nAChR) subtypes. α-conotoxin Mr1.7c (MrIC) is a 17 amino acid peptide that targets α7 nAChR. Although MrIC has no activating effect on α7 nAChR
Externí odkaz:
https://doaj.org/article/59b9fd8bde3d41f1acc5a78ea6fe96a6
Autor:
David J. Craik, Christina I. Schroeder, Akello J. Agwa, Mathilde R. Israel, Alexander Mueller, Irina Vetter, Jennifer R. Deuis, Hue N. T. Tran, Kirsten L. McMahon, Poanna Tran
Publikováno v:
J Biol Chem
Huwentoxin-IV (HwTx-IV) is a gating modifier peptide toxin from spiders that has weak affinity for the lipid bilayer. As some gating modifier toxins have affinity for model lipid bilayers, a tripartite relationship among gating modifier toxins, volta
Autor:
Kuok Yap, Irina Vetter, Jennifer R. Deuis, Hue N. T. Tran, Poanna Tran, Christina I. Schroeder, Kirsten L. McMahon, David J. Craik
Publikováno v:
Bioconjug Chem
Double-knotted peptides identified in venoms and synthetic bivalent peptide constructs targeting ion channels are emerging tools for the study of ion channel pharmacology and physiology. These highly complex and disulfide-rich peptides contain two in
Autor:
Mark A. T. Blaskovich, Alysha G. Elliott, Christina I. Schroeder, Rajeshwari Meli, Séverine Morisset-Lopez, Hue N. T. Tran, Sabrina Spiller, Hayeon Baik, Nayara Braga Emidio, Markus Muttenthaler, Annette G. Beck-Sickinger
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (13), pp.9484-9495. ⟨10.1021/acs.jmedchem.1c00767⟩
Journal of Medicinal Chemistry, 2021, 64 (13), pp.9484-9495. ⟨10.1021/acs.jmedchem.1c00767⟩
Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (13), pp.9484-9495. ⟨10.1021/acs.jmedchem.1c00767⟩
Journal of Medicinal Chemistry, 2021, 64 (13), pp.9484-9495. ⟨10.1021/acs.jmedchem.1c00767⟩
International audience; TFF3 regulates essential gastro- and neuroprotective functions, but its molecular mode of action remains poorly understood. Synthetic intractability and lack of reliable bioassays and validated receptors are bottlenecks for me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e711806df3a34b8bee790ad9eaf8c0
https://hal.archives-ouvertes.fr/hal-03335490
https://hal.archives-ouvertes.fr/hal-03335490
Autor:
Richard J. Lewis, Jennifer R. Deuis, Christina I. Schroeder, Irina Vetter, Hue N. T. Tran, Kirsten L. McMahon
Publikováno v:
Biomedicines, Vol 8, Iss 391, p 391 (2020)
Biomedicines
Volume 8
Issue 10
Biomedicines
Volume 8
Issue 10
Voltage-gated sodium (NaV) channel subtypes, including NaV1.7, are promising targets for the treatment of neurological diseases, such as chronic pain. Cone snail-derived µ
conotoxins are small, potent NaV channel inhibitors which represent
conotoxins are small, potent NaV channel inhibitors which represent
Autor:
Hue N T, Tran, Poanna, Tran, Jennifer R, Deuis, Akello J, Agwa, Alan H, Zhang, Irina, Vetter, Christina I, Schroeder
Publikováno v:
Bioconjugate chemistry. 31(1)
Disulfide-rich animal venom peptides targeting either the voltage-sensing domain or the pore domain of voltage-gated sodium channel 1.7 (Na
Autor:
Irina Vetter, Fernando Albericio, Åsa Andersson, Hue N. T. Tran, Markus Muttenthaler, Nayara Braga Emidio, Philip E. Dawson
Publikováno v:
Journal of Medicinal Chemistry
High susceptibility to proteolytic degradation in the gastrointestinal tract limits the therapeutic application of peptide drugs in gastrointestinal disorders. Linaclotide is an orally administered peptide drug for the treatment of irritable bowel sy