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DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives

Autor: Neumann, Fernanda, Gourdain, Stéphanie, Albac, Christelle, Dekker, Alain D., Bui, Linh Chi, Dairou, Julien, Schmitz-Afonso, Isabelle, Hue, Nathalie, Rodrigues-Lima, Fernando, Delabar, Jean M., Potier, Marie-Claude, Le Caër, Jean-Pierre, Touboul, David, Delatour, Benoît, Cariou, Kevin, Dodd, Robert H.

Publikováno v: Scientific Reports
Scientific Reports, 2018, 8, pp.2859. ⟨10.1038/s41598-018-20984-z⟩
Scientific Reports, 8:2859. Nature Publishing Group
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports, Nature Publishing Group, 2018, 8, pp.2859. ⟨10.1038/s41598-018-20984-z⟩

International audience; Inhibition of DYRK1A kinase, produced by chromosome 21 and consequently overproduced in trisomy 21 subjects, has been suggested as a therapeutic approach to treating the cognitive deficiencies observed in Down syndrome (DS). W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1567651c2ba665159ee0e253160c218d
https://hal.sorbonne-universite.fr/hal-02292094/document

Large Diversity and Original Structures of Acyl-Homoserine Lactones in Strain MOLA 401, a Marine Rhodobacteraceae Bacterium

Autor: Doberva, Margot, Stien, Didier, Sorres, Jonathan, Hue, Nathalie, Sanchez-Ferandin, Sophie, Eparvier, Véronique, Ferandin, Yoan, Lebaron, Philippe, Lami, Raphaël

Publikováno v: Frontiers in Microbiology
Frontiers in Microbiology, 2017, 8, pp.1152. ⟨10.3389/fmicb.2017.01152⟩
Frontiers in Microbiology, Vol 8 (2017)
Frontiers in Microbiology, Frontiers Media, 2017, 8, pp.1152. ⟨10.3389/fmicb.2017.01152⟩

International audience; Quorum sensing (QS) is a density-dependent mechanism allowing bacteria to synchronize their physiological activities, mediated by a wide range of signaling molecules including N-acyl-homoserine lactones (AHLs). Production of A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4777df6fd19579cb18866bd7d428e169
https://hal.sorbonne-universite.fr/hal-01556563/document

Additional file 4: of Transcriptome analysis revealed that a quorum sensing system regulates the transfer of the pAt megaplasmid in Agrobacterium tumefaciens

Autor: Mhedbi-Hajri, Nadia, Yahiaoui, Noura, Mondy, Samuel, Hue, Nathalie, PĂŠlissier, Franck, Faure, Denis, Dessaux, Yves

The 32 differentially expressed genes identified by RNA-seq. Only changes above 3 fold with a p-value lower than 5 10 â 2 were considered significant. All differentially expressed genes were upregulated in P4 when compared to P4cinI. (PDF 285Â kb)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::066f9bf5b5a803d731678cb44e5ffcf8