Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line

Autor: Gescher Andreas, Gallacher-Horley Barbara, Fox Louise H, Howells Lynne M, Hudson E Ann, Manson Margaret M

Publikováno v: BMC Cancer, Vol 3, Iss 1, p 2 (2003)

Abstract Background Many tumours undergo disregulation of polyamine homeostasis and upregulation of ornithine decarboxylase (ODC) activity, which can promote carcinogenesis. In animal models of colon carcinogenesis, inhibition of ODC activity by difl

Externí odkaz: https://doaj.org/article/0da7189a5c8e4605865e049fd002c428

Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line.

Autor: Hudson, E. Ann¹ eah5@le.ac.uk, Howells, Lynne M.¹ lh28@le.ac.uk, Gallacher-Horley, Barbara² bg10@le.ac.uk, Fox, Louise H.¹ lhf2@le.ac.uk, Gescher, Andreas³ ag15@le.ac.uk, Manson, Margaret M.¹ mmm2@le.ac.uk

Publikováno v: BMC Cancer. 2003, Vol. 3, p2-18. 18p. 1 Chart, 9 Graphs.

Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells

Autor: Squires, Matthew S.¹, Hudson, E. Ann¹, Howells, Lynne¹, Sale, Stewart², Houghton, Catherine E.³, Jones, J. Louise⁴, Fox, Louise H.¹, Dickens, Martin⁵, Prigent, Sally A.⁵ sap8@le.ac.uk, Manson, Margaret M.¹ mmm2@le.ac.uk

Publikováno v: Biochemical Pharmacology. Feb2003, Vol. 65 Issue 3, p361. 16p.

Characterization of a promoter for γ-glutamyl transpeptidase activated in rat liver in response to aflatoxin B1 and ethoxyquin¹.

Autor: Griffiths, Susan A., Good, Valerie M., Gordon, Linda A., Hudson, E. Ann, Barrett, Mandy C., Munks, Rebecca J. L., Manson, Margaret M.

Publikováno v: Molecular Carcinogenesis; Dec1995, Vol. 14 Issue 4, p251-262, 12p

Inhibition of phosphatidylinositol 3-kinase/protein kinase B signaling is not sufficient to account for indole-3-carbinol-induced apoptosis in some breast and prostate tumor cells.

Autor: Howells LM; Cancer Biomarkers and Prevention Group, Department of Biochemistry and Cancer Studies, Biocentre, University of Leicester, Leicester, United Kingdom., Hudson EA, Manson MM

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2005 Dec 01; Vol. 11 (23), pp. 8521-7.