Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Huda Zahid"'
Autor:
Hideki Aihara, Huda Zahid, Marcus Fischer, Ke Shi, Camila O. dos Santos, Ernst Schönbrunn, Manjulata Singh, A. Chan, Joseph W. Landry, Caroline R. Buchholz, Stanley Nithianantham, William C. K. Pomerantz, Michael F. Ciccone
Publikováno v:
J Med Chem
The nucleosome remodeling factor (NURF) alters chromatin accessibility through interactions with its largest subunit,the bromodomain PHD finger transcription factor BPTF. BPTF is overexpressed in several cancers and is an emerging anticancer target.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c87b96779fd84ea2f54e480679e3403
https://doi.org/10.1021/acs.jmedchem.1c01294
https://doi.org/10.1021/acs.jmedchem.1c01294
Autor:
Huda Zahid, Jeff Costello, Jennifer Kimbrough, Marisa Actis, Zoran Rankovic, William Pomerantz
Targeted protein degradation is an emerging technology that can be used for modulating the activity of epigenetic protein targets. Among bromodomain-containing proteins, a number of degraders for the BET family have been developed while non-BET bromo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb117d7df403effc8ad5bed01abf55ef
https://doi.org/10.26434/chemrxiv-2022-41npn
https://doi.org/10.26434/chemrxiv-2022-41npn
Publikováno v:
Curr Opin Chem Biol
Nucleosome remodeling provides access to genomic DNA for recruitment of the transcriptional machinery to mediate gene expression. The aberrant function of nucleosome remodeling complexes has been correlated to human cancer, making them emerging thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ef3a8633c7c4cf93b48b29a849a126
https://doi.org/10.1016/j.cbpa.2021.02.003
https://doi.org/10.1016/j.cbpa.2021.02.003
Publikováno v:
Biochemistry
Epigenetic reader domains regulate chromatin structure and modulate gene expression through the recognition of post-translational modifications on histones. Recently, reader domains have also been found to harbor double-stranded (ds) DNA-binding acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0460e3af4febe0cb1ad37588ab6efeb2
https://europepmc.org/articles/PMC9682295/
https://europepmc.org/articles/PMC9682295/
Autor:
Usama B. Farrukh, Aishah Bilal, Huda Zahid, Maheen Iqbal, Safia Manzoor, Farhat Firdous, Muhammad Furqan, Muhammad Azeem, Abdul‐Hamid Emwas, Meshari Alazmi, Xin Gao, Rahman S. Z. Saleem, Amir Faisal
Publikováno v:
ChemistrySelect. 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79cb3df82d4dd2fd7b1793ba557d55c7
https://doi.org/10.1002/slct.202104218
https://doi.org/10.1002/slct.202104218
Autor:
Jorden A. Johnson, Siva Kumar Talluri, Peter D. Ycas, A. Chan, William C. K. Pomerantz, Ernst Schönbrunn, Noelle M. Olson, Huda Zahid
Publikováno v:
Org Biomol Chem
Bromodomain-containing proteins regulate transcription through protein-protein interactions with chromatin and serve as scaffolding proteins for recruiting essential members of the transcriptional machinery. One such protein is the bromodomain and PH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf085b8923b1b6fea179d9a96f185443
https://doi.org/10.1039/d0ob00506a
https://doi.org/10.1039/d0ob00506a
Autor:
Huarui Cui, Anand Divakaran, Zachariah J. Hoell, Mikael O. Ellingson, Cole R. Scholtz, Huda Zahid, Jorden A. Johnson, Elizabeth C. Griffith, Clifford T. Gee, Amani L. Lee, Shalil Khanal, Ke Shi, Hideki Aihara, Vijay H. Shah, Richard E. Lee, Daniel A. Harki, William C. K. Pomerantz
Publikováno v:
J Med Chem
Chemical probes for epigenetic proteins are essential tools for dissecting the molecular mechanisms for gene regulation and therapeutic development. The bromodomain and extra-terminal (BET) proteins are master transcriptional regulators. Despite prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b7a4c86e5079b9c8290b3133b80308
https://pubmed.ncbi.nlm.nih.gov/35007061
https://pubmed.ncbi.nlm.nih.gov/35007061
Autor:
Huda Zahid, Wenwei Lin, Anand Divakaran, Daniel A. Harki, Taosheng Chen, William C. K. Pomerantz
Targeted protein degradation is a powerful induced-proximity tool to control cellular concentrations of native proteins using small molecules. However, the design of selectivity in protein degradation remains challenging. In the case of Bromodomain a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679319e949e9d1c9719097be01674f53
https://doi.org/10.33774/chemrxiv-2021-zvq4t
https://doi.org/10.33774/chemrxiv-2021-zvq4t
Autor:
William C. K. Pomerantz, Huarui Cui, Nora R. Vail, Ke Shi, Anand Divakaran, Jorden A. Johnson, Huda Zahid, Grover P. Miller, Daniel A. Harki, Joseph J. Topczewski, Caroline R. Buchholz, Hideki Aihara, Mary A. Schleiff, Angela S. Carlson
Publikováno v:
J Med Chem
The bromodomain and extra terminal (BET) protein family recognizes acetylated lysines within histones and transcription factors using two N-terminal bromodomains, D1 and D2. The protein–protein interactions between BET bromodomains, acetylated hist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7902ab86e4ce714d58bf51d36986f5
https://europepmc.org/articles/PMC8491147/
https://europepmc.org/articles/PMC8491147/
Autor:
Anand Divakaran, Jorden A. Johnson, Ke Shi, Huarui Cui, Hideki Aihara, Daniel A. Harki, Anil K. Pandey, Mikael O Ellingson, Huda Zahid, William C. K. Pomerantz, Zachariah J Hoell
Publikováno v:
Angew Chem Int Ed Engl
Bromodomain and extra-terminal (BET) family proteins, BRD2-4 and T, are important drug targets; however, the biological functions of each bromodomain remain ill-defined. Chemical probes that selectively inhibit a single BET bromodomain are lacking, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b79da71e3806f7d8c1a0a9ceab6903e
https://pubmed.ncbi.nlm.nih.gov/32975004
https://pubmed.ncbi.nlm.nih.gov/32975004