Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Huda H. Al-Khalaf"'
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 6, Pp 631-640 (2013)
Activated cancer-associated fibroblasts (CAFs) or myofibroblasts not only facilitate tumor growth and spread but also affect tumor response to therapeutic agents. Therefore, it became clear that efficient therapeutic regimens should also take into ac
Externí odkaz:
https://doaj.org/article/24651a2706fa4174a3e6b5d4eb2cb539
Publikováno v:
Oncotarget
Osteosarcoma is the most common malignant bone tumor in children, adolescents, and young adults. This pleiomorphic tumor depends on new blood vessel development, also known as angiogenesis, for tumor growth and metastasis. Therefore, it’s of utmost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cefe6cac6eac096acaaed7cf789bdee
https://doi.org/10.18632/oncotarget.27115
https://doi.org/10.18632/oncotarget.27115
Publikováno v:
Oncogenesis
Oncogenesis, Vol 9, Iss 8, Pp 1-12 (2020)
Oncogenesis, Vol 9, Iss 8, Pp 1-12 (2020)
The AU-rich element RNA-binding protein 1 (AUF1) is an RNA-binding protein, which can both stabilize and destabilize the transcripts of several cancer-related genes. Since epithelial-to-mesenchymal transition (EMT) and the acquisition of cancer stem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93079f158a6c3d784e2a3610a60b23e4
https://pubmed.ncbi.nlm.nih.gov/32759946
https://pubmed.ncbi.nlm.nih.gov/32759946
Publikováno v:
Molecular Cancer Research. 16:1299-1308
p16INK4A and p53 are two major tumor suppressor proteins that are both upregulated in response to various cellular stresses and during senescence and aging. p53 is a well-characterized transcription factor, while p16INK4A a cyclin-dependent kinase in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c12842c8ea11685b801c68bec12509
https://doi.org/10.1158/1541-7786.mcr-18-0017
https://doi.org/10.1158/1541-7786.mcr-18-0017
Autor:
Huda H Al-Khalaf, Dilek Colak, Maher Al-Saif, Albandary Al-Bakheet, Siti-Faujiah Hendrayani, Nujoud Al-Yousef, Namik Kaya, Khalid S Khabar, Abdelilah Aboussekhra
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21111 (2011)
BackgroundThe cyclin-D/CDK4,6/p16(INK4a)/pRB/E2F pathway, a key regulator of the critical G1 to S phase transition of the cell cycle, is universally disrupted in human cancer. However, the precise function of the different members of this pathway and
Externí odkaz:
https://doaj.org/article/d7f9ff83f9be405ab2aa0df2055b4300
Publikováno v:
Molecular Carcinogenesis. 56:1687-1702
p16INK4A and p53 are two important tumor suppressor proteins that play essential roles during cell proliferation and aging through regulating the expression of several genes. Here, we report that p16INK4A and p53 co-regulate a plethora of transcripts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02205d620528c267f6fa015c49bf36f3
https://doi.org/10.1002/mc.22627
https://doi.org/10.1002/mc.22627
Publikováno v:
Mol Cell Biol
During aging, cellular plasticity and senescence play important roles in tissue regeneration and the pathogenesis of different diseases, including cancer. We have recently shown that senescent breast luminal cells can activate their adjacent stromal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ca8c03f3e7ff62038e28448b26fccf
https://pubmed.ncbi.nlm.nih.gov/32015100
https://pubmed.ncbi.nlm.nih.gov/32015100
Publikováno v:
Molecular Carcinogenesis. 56:985-999
Senescence and epithelial-to-mesenchymal transition (EMT) processes are under the control of common tumor suppressor proteins, EMT transcription factors, and microRNAs. However, the molecular mechanisms that coordinate the functional link between sen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be42d13d708dcf05a48e46a983c0ff42
https://doi.org/10.1002/mc.22564
https://doi.org/10.1002/mc.22564
Autor:
Asma Tulbah, Falah Al-Mohanna, Abdelilah Aboussekhra, Bothaina Al-Harbi, Adher Al-Sayed, Abdulaziz Jarman, Huda H. Al-Khalaf, Maria Arafah
Publikováno v:
Molecular and Cellular Biology. 39
Increasing evidence supports the critical role of active stromal adipocytes in breast cancer development and spread. However, the mediators and the mechanisms of action are still elusive. We show here that cancer-associated adipocytes (CAAs) isolated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f93fa127a7d70cb58910f7bcc440a62
https://doi.org/10.1128/mcb.00332-18
https://doi.org/10.1128/mcb.00332-18
Autor:
Huda A. Al-Howail, Amer Al-Mazrou, Abdelilah Aboussekhra, Ibrahim Al-Jammaz, Huda H. Al-Khalaf, Mashael Al-Swailem, Basem Al-Otaibi, Abeer Al-Qasem
Publikováno v:
Molecular Carcinogenesis. 55:233-244
Colorectal cancer (CRC) is a major cause of cancer morbidity and mortality worldwide. Although response rates and overall survival have been improved in recent years, resistance to multiple drug combinations is inevitable. Therefore, the development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a16a1474bc081338f2ad645e84fc0da1
https://doi.org/10.1002/mc.22271
https://doi.org/10.1002/mc.22271