Discovery of BI-9508, a Brain-Penetrant GPR88-Receptor-Agonist Tool Compound for In Vivo Mouse Studies.

Autor: Fer M; Domain Therapeutics, 67400 Illkirch, France., Amalric C; Domain Therapeutics, 67400 Illkirch, France., Arban R; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach an der Riß, Germany., Baron L; Domain Therapeutics, 67400 Illkirch, France., Ben Hamida S; Douglas Research Center, Department of Psychiatry, McGill University, Montréal, Quebec H4H 1R3, Canada.; INSERM UMR 1247- Research Group on Alcohol & Pharmacodependences (GRAP), Université de Picardie Jules Verne, 80000 Amiens, France., Breh-Schlanser P; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach an der Riß, Germany., Cui Y; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach an der Riß, Germany., Darcq E; Douglas Research Center, Department of Psychiatry, McGill University, Montréal, Quebec H4H 1R3, Canada.; INSERM UMR-S1329, Strasbourg Translational Neuroscience & Psychiatry, University of Strasbourg, Strasbourg 67084, France., Eickmeier C; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach an der Riß, Germany., Faye V; Domain Therapeutics, 67400 Illkirch, France., Franchet C; Domain Therapeutics, 67400 Illkirch, France., Frauli M; Domain Therapeutics, 67400 Illkirch, France., Halter C; Domain Therapeutics, 67400 Illkirch, France., Heyer M; Domain Therapeutics, 67400 Illkirch, France., Hoenke C; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach an der Riß, Germany., Hoerer S; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach an der Riß, Germany., Hucke OT; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach an der Riß, Germany., Joseph C; Domain Therapeutics, 67400 Illkirch, France., Kieffer BL; Douglas Research Center, Department of Psychiatry, McGill University, Montréal, Quebec H4H 1R3, Canada.; INSERM UMR-S1329, Strasbourg Translational Neuroscience & Psychiatry, University of Strasbourg, Strasbourg 67084, France., Lebrun L; Domain Therapeutics, 67400 Illkirch, France., Lotz N; Domain Therapeutics, 67400 Illkirch, France., Mayer S; Domain Therapeutics, 67400 Illkirch, France., Omrani A; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach an der Riß, Germany., Recolet M; Domain Therapeutics, 67400 Illkirch, France., Schaeffer L; Domain Therapeutics, 67400 Illkirch, France., Schann S; Domain Therapeutics, 67400 Illkirch, France., Schlecker A; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach an der Riß, Germany., Steinberg E; Domain Therapeutics, 67400 Illkirch, France., Viloria M; Domain Therapeutics, 67400 Illkirch, France., Würstle K; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach an der Riß, Germany., Young K; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach an der Riß, Germany., Zinser A; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach an der Riß, Germany., Montel F; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach an der Riß, Germany., Klepp J; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach an der Riß, Germany.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Jul 11; Vol. 67 (13), pp. 11296-11325. Date of Electronic Publication: 2024 Jul 01.