Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Huck K. Grover"'
Publikováno v:
Chemical Communications. 57:10556-10559
A stereoselective, copper-catalyzed, arene C(sp2)–H functionalization/Michael-type annulation reaction involving α-diazocarbonyl compounds has been developed. The method features low catalyst loadings, high yields, and excellent regio and stereose
Publikováno v:
Organic Letters. 22:224-229
The decomposition of diazodicarbonyl compounds in the presence of various metal catalysts has become a reliable method for the functionalization of indoles via carbenoid intermediates. Exploiting t...
Autor:
Kenneth Virgel N. Esguerra, Jordan K. Thompson, Danny Q. Thach, Zachary G. Brill, Huck K. Grover, Thomas J. Maimone
Publikováno v:
Angew Chem Int Ed Engl
The ophiobolin sesterterpenes are notable plant pathogens which have recently elicited significant chemical and biological attention because of their intriguing carbogenic frameworks, reactive functionalities, and emerging anticancer profiles. Report
Publikováno v:
The Journal of organic chemistry. 86(17)
Studies on Knoevenagel condensations between conjugated dienals and 4-hydroxy-2-pyridone/quinolone-type 1,3-dicarbonyl equivalents led to the development of a simple one-pot strategy to access citridone A and related synthetic cyclopenta[b]furopyrido
Publikováno v:
Organic letters. 23(14)
Indolyl α-diazocarbonyl compounds have proven to be effective starting materials for the construction of various 2,3-ring fused indole frameworks. Activation of the diazo functional group under metal catalysis generates a spiro-cyclic indolenine-typ
Publikováno v:
Science (New York, N.Y.), vol 352, iss 6289
A radical route to ophiobolin rings Chemical ring-closing cascades resemble molecular yoga. One reactive site on a linear precursor can pull the whole molecule into a remarkably complex polycyclic arrangement. Cyclase enzymes rely on substantial inte
Autor:
Michael A. Kerr, Huck K. Grover
Publikováno v:
Synlett. 26:815-819
A preliminary investigation into the prospect of a common synthetic intermediate for the synthesis of a variety of indole alkaloids has led to a synthesis of substituted piperidinones and the corresponding piperidines. These common natural product co
Publikováno v:
Organic & Biomolecular Chemistry. 13:655-671
This review summarizes research directed towards the formation of carbocyclic adducts from donor-acceptor cyclopropanes. The focus of the review is on annulation and cycloaddition reactions (both inter- and intramolecularly) mediated by Lewis or prot
Publikováno v:
The Journal of Organic Chemistry. 78:10534-10540
Treatment of indolylmethyl Meldrum's acids with catalytic scandium triflate and a variety of nucleophiles results in the nucleophilic displacement of the Meldrum's acid moiety via a gramine-type fragmentation. The reaction is useful for the generatio
Publikováno v:
ChemInform. 47
Cyclase enzymes weave simple polyprenyl chains into the elaborate polycyclic ring systems of terpenes, a sequence that is often difficult to emulate under abiotic conditions. Here we report a disparate synthetic approach to complex terpenes whereby s