Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Huck Hui Ng"'
Autor:
Zhengyi Li, Haiyan Xu, Jiaqun Li, Xiao Xu, Junjiao Wang, Danya Wu, Jiateng Zhang, Juan Liu, Ziwei Xue, Guankai Zhan, Bobby Cheng Peow Tan, Di Chen, Yun-Shen Chan, Huck Hui Ng, Wanlu Liu, Chih-Hung Hsu, Dan Zhang, Yang Shen, Hongqing Liang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Acquisition of new stem cell fates relies on the dissolution of the prior regulatory network sustaining the existing cell fates. Currently, extensive insights have been revealed for the totipotency regulatory network around the zygotic genom
Externí odkaz:
https://doaj.org/article/35b1d34d886b45658cb76ff50e98280b
Autor:
Alfred Xuyang Sun, Qiang Yuan, Shawn Tan, Yixin Xiao, Danlei Wang, Audrey Tze Ting Khoo, Levena Sani, Hoang-Dai Tran, Paul Kim, Yong Seng Chiew, Kea Joo Lee, Yi-Chun Yen, Huck Hui Ng, Bing Lim, Hyunsoo Shawn Je
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 1942-1953 (2016)
Gamma-aminobutyric acid (GABA)-releasing interneurons play an important modulatory role in the cortex and have been implicated in multiple neurological disorders. Patient-derived interneurons could provide a foundation for studying the pathogenesis o
Externí odkaz:
https://doaj.org/article/091f2fb94fb34db09bbe7c3f12c0d72b
Autor:
Zhipeng Ai, Xinyu Xiang, Yangquan Xiang, Iwona Szczerbinska, Yuli Qian, Xiao Xu, Chenyang Ma, Yaqi Su, Bing Gao, Hao Shen, Muhammad Nadzim Bin Ramli, Di Chen, Yue Liu, Jia-jie Hao, Huck Hui Ng, Dan Zhang, Yun-Shen Chan, Wanlu Liu, Hongqing Liang
Publikováno v:
Cell reports. 40(8)
Endogenous retroviruses (ERVs) have been reported to participate in pre-implantation development of mammalian embryos. In early human embryogenesis, different ERV sub-families are activated in a highly stage-specific manner. How the specificity of ER
Autor:
Tae Hwan Kwak, Chanhyeok Park, Kee-Pyo Kim, Im Joo Rhyu, Woong Sun, Kwon Ho Hong, Dong Wook Han, Hyunsoo Shawn Je, Huck-Hui Ng, Ji Eun Na, ChiHye Chung, Sai Hali, Ji Hyun Kang, Ju Hyun Lee, Junghyun Jo, Nam Kim, Jonghun Kim, Ha Kyun Ryu, Jeongwoo Kwon
Publikováno v:
STEM CELLS. 38(6):727-740
Recent studies have demonstrated the generation of midbrain-like organoids (MOs) from human pluripotent stem cells. However, the low efficiency of MO generation and the relatively immature and heterogeneous structures of the MOs hinder the translatio
Autor:
Tushar Warrier, Chadi El Farran, Yingying Zeng, Benedict Shao Quan Ho, Don Loi Xu, Qiuye Bao, Zi Hao Zheng, Xuezhi Bi, Kelly Yu Sing Tan, Huck Hui Ng, Derrick Sek Tong Ong, Justin Jang Hann Chu, Amartya Sanyal, Melissa Jane Fullwood, James Collins, Hu Li, Jian Xu, Yuin-Han Loh
SETDB1 is a key regulator of lineage-specific genes and endogenous retroviral elements (ERVs) through its deposition of repressive H3K9me3 mark. Apart from its H3K9me3 regulatory role, SETDB1 has seldom been studied in terms of its other potential re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a095b68c3ab5551585bb1f5de6ffe3d2
https://doi.org/10.1101/2022.01.27.478011
https://doi.org/10.1101/2022.01.27.478011
Autor:
Tushar Warrier, Chadi El Farran, Yingying Zeng, Benedict Shao Quan Ho, Qiuye Bao, Zi Hao Zheng, Xuezhi Bi, Huck Hui Ng, Derrick Sek Tong Ong, Justin Jang Hann Chu, Amartya Sanyal, Melissa Jane Fullwood, James J Collins, Hu Li, Jian Xu, Yuin-Han Loh
Publikováno v:
Nucleic Acids Research, 50, 7326-7349
Nucleic Acids Research, 50, 13, pp. 7326-7349
Nucleic Acids Research, 50, 13, pp. 7326-7349
SETDB1 is a key regulator of lineage-specific genes and endogenous retroviral elements (ERVs) through its deposition of repressive H3K9me3 mark. Apart from its H3K9me3 regulatory role, SETDB1 has seldom been studied in terms of its other potential re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd233beb6192832526b725707db2e5f
https://doi.org/10.1093/nar/gkac531
https://doi.org/10.1093/nar/gkac531
Autor:
Mui Hoon Nai, Hoang-Dai Tran, Huck-Hui Ng, Chwee Teck Lim, Kah-Leong Lim, Haidun Yan, Koji Itahana, Menglan Zhang, Stephanie Wai Lin Lim, Qiang Yuan, Yoko Itahana, Giuseppe D'Agostino, Yong-hui Jiang, Alfred Xuyang Sun, Eng-King Tan, Danlei Wang, Hidayat Lokman, Owen J. L. Rackham, Weonjin Yu, Stuart A. Cook, Grace Lim, Ya Yin Chang, Masahiro Fukuda, Hyunsoo Shawn Je, Jiong Tang
Publikováno v:
Science. 366:1486-1492
Hyperexcitable neurons in brain organoids Individuals with Angelman syndrome experience intellectual disability and seizures throughout their lives. In this condition, ubiquitin-mediated degradation of a key potassium channel is disrupted, allowing f
Autor:
Chun Yi Ng, Khang Leng Lee, Mark D. Muthiah, Kan-Xing Wu, Florence W. J. Chioh, Konstanze Tan, Gwyneth S. T. Soon, Asim Shabbir, Wai Mun Loo, Zun Siong Low, Qingfeng Chen, Nguan Soon Tan, Huck Hui Ng, Yock Young Dan, Christine Cheung
The top cause of mortality in patients with non-alcoholic fatty liver disease (NAFLD) is cardiovascular complications. However, the mechanisms of NAFLD-associated vasculopathy remain understudied. We developed blood outgrowth endothelial cell (BOEC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05633d097bd18cd0175e7b2892be6d39
https://doi.org/10.1101/2021.12.13.472411
https://doi.org/10.1101/2021.12.13.472411
Publikováno v:
Cell Regeneration
Cell Regeneration, Vol 10, Iss 1, Pp 1-19 (2021)
Cell Regeneration, Vol 10, Iss 1, Pp 1-19 (2021)
Building human organs in a dish has been a long term goal of researchers in pursue of physiologically relevant models of human disease and for replacement of worn out and diseased organs. The liver has been an organ of interest for its central role i
Autor:
Hidayat Lokman, Huck-Hui Ng, Audrey Tze Ting Khoo, Wei-Yi Ong, Junghyun Jo, Grace Lim, Hoang Dai Tran, Seung-Jae Lee, Weonjin Yu, Lin Yang, Lai Ping Yaw, Ya Yin Chang, Jessica Jiaxin Xie, Kah-Leong Lim, Bin Xiao, Eng-King Tan, Tzuen Yih Saw, Byung Chul Jung, Alfred Xuyang Sun, Hyunsoo Shawn Je
Publikováno v:
Annals of neurology. 90(3)
Objective: We utilized human midbrain-like organoids (hMLOs) generated from human pluripotent stem cells carrying glucocerebrosidase gene (GBA1) and α-synuclein (α-syn; SNCA) perturbations to investigate genotype-to-phenotype relationships in Parki