Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Hubert P. Flores"'
Autor:
LinLin Tian, Yuanxuan Xia, Hubert P Flores, Meghan C Campbell, Stephen M Moerlein, Joel S Perlmutter
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132064 (2015)
Apathy commonly occurs in Parkinson disease (PD) patients; however, the role of dopamine in the pathophysiology of apathy remains elusive. We previously demonstrated that dopaminergic dysfunction within the ventral tegmental area (VTA)-nucleus accumb
Externí odkaz:
https://doaj.org/article/d39a8ebf3df04e3da28cb4ab3d03474f
Publikováno v:
Pesquimat, Vol 13, Iss 1 (2014)
The aim of this paper is to briefly discuss some strategies that have been developed for the construction of trigonometric polynomial m0 under certain conditions. Also show the relationship between the function scale ϕ, the wavelet and the trigonome
Externí odkaz:
https://doaj.org/article/4dbd769bdac84e4aa3004c60e0155ff0
Autor:
Susan Searles Nielsen, Susan R. Criswell, Lianne Sheppard, John L Huang, Brad A. Racette, Harvey Checkoway, Mark N. Warden, Stephen M. Moerlein, Noah S. Seixas, Hubert P. Flores, Joel S. Perlmutter
Publikováno v:
NeuroToxicology. 64:43-49
Occupational manganese (Mn) exposure is associated with the development of parkinsonism; however, the mechanism of neurotoxicity is unknown. Brain positron emission tomography (PET) imaging provides a non-invasive method of assessing dopamineric neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e3dbfe45abe7b8bc3ce40cf0b5b8a9
https://doi.org/10.1016/j.neuro.2017.07.004
https://doi.org/10.1016/j.neuro.2017.07.004
Autor:
Joel S. Perlmutter, Xuyi Yue, Kota Kaneshige, Zhude Tu, Stanley M. Parsons, Xiang Zhang, Hongjun Jin, Zonghua Luo, Hui Liu, Hubert P. Flores
Publikováno v:
Org. Biomol. Chem.. 15:5197-5209
The vesicular acetylcholine transporter (VAChT) is a reliable biomarker for assessing cholinergic dysfunction associated with dementia. We recently reported three new potent and selective carbon-11 labeled VAChT radiotracers. Herein, we report the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e6c9e1eb391576114a1da805894e55
https://doi.org/10.1039/c7ob00854f
https://doi.org/10.1039/c7ob00854f
Autor:
Brad A. Racette, Harvey Checkoway, Mark N. Warden, Susan Searles Nielsen, Susan R. Criswell, Jason Lenox-Krug, Sophia Racette, Lianne Sheppard, Hubert P. Flores
Objective T1-weighted brain magnetic resonance imaging (MRI) of the basal ganglia provides a noninvasive measure of manganese (Mn) exposure, and may also represent a biomarker for clinical neurotoxicity. Methods We acquired T1-weighted MRI scans in 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980945e6366b3f21e90625008b747bc6
https://europepmc.org/articles/PMC7098806/
https://europepmc.org/articles/PMC7098806/
Autor:
Hongjun Jin, Xuyi Yue, Stanley M. Parsons, Prashanth K. Padakanti, Hui Liu, Hubert P. Flores, Lihai Yu, Xiang Zhang, Kota Kaneshige, Zhude Tu, Joel S. Perlmutter
Publikováno v:
Bioorganic & medicinal chemistry, vol 23, iss 15
Nine fluorine-containing vesicular acetylcholine transporter (VAChT) inhibitors were synthesized and screened as potential PET tracers for imaging the VAChT. Compound 18a was one of the most promising carbonyl-containing benzovesamicol analogs; the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3601589b6deaaa2f1a0978bcff741767
https://doi.org/10.1016/j.bmc.2015.05.058
https://doi.org/10.1016/j.bmc.2015.05.058
Autor:
Zhude Tu, Zonghua Luo, Hongjun Jin, Stanley M. Parsons, LinLin Tian, Ethan DeNardo McSpadden, Xuyi Yue, Xiang Zhang, Hui Liu, Hubert P. Flores, Joel S. Perlmutter
Twelve optically pure enantiomers were obtained using either crystallization or chiral high performance liquid chromatography (HPLC) separation methodologies to resolve six racemic sigma-1 (σ1) receptor ligands. The in vitro binding affinities of ea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a65eaf4115f5099d1642bceb881323b
https://europepmc.org/articles/PMC5303003/
https://europepmc.org/articles/PMC5303003/
Autor:
Xiang Zhang, Hongjun Jin, Zhude Tu, Ruike Wang, Prashanth K. Padakanti, Stanley M. Parsons, Joel S. Perlmutter, Junfeng Li, Hubert P. Flores, Jinquan Cui
Publikováno v:
Molecular imaging and biology, vol 16, iss 6
PurposeThe vesicular acetylcholine transporter (VAChT) is a specific biomarker for imaging presynaptic cholinergic neurons. Herein, two potent and selective (11)C-labeled VAChT inhibitors were evaluated in rodents and nonhuman primates for imaging VA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b29749f5400b0881faaa0abf8379e4aa
https://doi.org/10.1007/s11307-014-0749-9
https://doi.org/10.1007/s11307-014-0749-9
Autor:
Yi Su, Morvarid Karimi, Hubert P. Flores, Joel S. Perlmutter, Tom O. Videen, Stephen M. Moerlein
Publikováno v:
Movement Disorders. 28:2002-2006
Background: Multiple studies have demonstrated decreases in striatal D2-like (D2, D3) radioligand binding in primary focal dystonias. Although most investigations have focused on D2-specific receptors (D2R), a recent study suggests that the decreased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63547636952159da9ab1946433e96971
https://doi.org/10.1002/mds.25720
https://doi.org/10.1002/mds.25720
Autor:
Gammon M. Earhart, Fredy J. Revilla, Samer D. Tabbal, Kelly K. Hill, Mwiza Ushe, Hubert P. Flores, Meghan C. Campbell, Johanna M Hartlein, Heather M. Lugar, Tom O. Videen, Joel S. Perlmutter, Tamara Hershey, Morvarid Karimi, Marie E. McNeely
Publikováno v:
Experimental Neurology. 241:105-112
Objectives The effects of subthalamic nucleus (STN) deep brain stimulation (DBS) on gait and balance vary and the underlying mechanisms remain unclear. DBS location may alter motor benefit due to anatomical heterogeneity in STN. The purposes of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a0b775ac843fe7994f6e842df056b1
https://doi.org/10.1016/j.expneurol.2012.12.003
https://doi.org/10.1016/j.expneurol.2012.12.003