Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Hubert Ming Tse"'
Publikováno v:
The Journal of Immunology. 208:103.06-103.06
Proinflammatory cytokines, reactive oxygen species (ROS), and T cells contribute to β-cell destruction in Type 1 diabetes (T1D). NADPH oxidase (NOX) generate superoxide, a precursor for a variety of ROS, regulate cell survival, differentiation, sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff7e8673d1d1689de799b8aa21c873f1
https://doi.org/10.4049/jimmunol.208.supp.103.06
https://doi.org/10.4049/jimmunol.208.supp.103.06
Autor:
Jared P Taylor, Hubert Ming Tse
Publikováno v:
The Journal of Immunology. 206:64.08-64.08
Single nucleotide polymorphisms (SNP) in the human IFIH1 gene are associated with autoimmunity and interferonopathies. The rs1990760 SNP, which results in an amino acid change from alanine to threonine at position 946 (A946T), is associated with seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d97c37006a257c4cc9e329602bbcc9e
https://doi.org/10.4049/jimmunol.206.supp.64.08
https://doi.org/10.4049/jimmunol.206.supp.64.08
Publikováno v:
The Journal of Immunology. 202:178.7-178.7
Viral infections can trigger the synthesis of proinflammatory cytokines and free radicals that contribute to pancreatic β-cell destruction leading to Type 1 diabetes (T1D). We previously demonstrated that Coxsackievirus B3 (CB3) infection of Non-Obe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b3d7bb76bc16c7ef233bb34adaf1a7a
https://doi.org/10.4049/jimmunol.202.supp.178.7
https://doi.org/10.4049/jimmunol.202.supp.178.7
Publikováno v:
The Journal of Immunology. 200:55.28-55.28
Islet transplantation can restore β-cell function in patients with Type 1 diabetes (T1D), however, limited islet availability, toxicity of immunosuppressants, and poor graft survival are major hurdles for clinical application. We hypothesize that is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7de130ccb89ffb089846b9d2f39e9675
https://doi.org/10.4049/jimmunol.200.supp.55.28
https://doi.org/10.4049/jimmunol.200.supp.55.28
Publikováno v:
The Journal of Immunology. 200:162.12-162.12
While microbial infections can trigger autoimmune diabetes, ultimately, innate immune activation and the synthesis of free radicals, proinflammatory cytokines, and Type I interferons contribute to pancreatic β-cell destruction in Type 1 diabetes (T1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cc5ea7ab2fe585c70aad6d1ab6b29ff
https://doi.org/10.4049/jimmunol.200.supp.162.12
https://doi.org/10.4049/jimmunol.200.supp.162.12
Publikováno v:
The Journal of Immunology. 198:58.10-58.10
Free radicals contribute to Type 1 diabetes (T1D) autoimmune responses. We recently demonstrated that superoxide-deficient CD4 T cells exhibited increased effector responses and diabetogenicity, but the redox-dependent mechanism(s) mediating T cell a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12c8ae94eb5419823e55e3bc4fe8d12a
https://doi.org/10.4049/jimmunol.198.supp.58.10
https://doi.org/10.4049/jimmunol.198.supp.58.10
Autor:
Nadine N Morgan, Hubert Ming Tse
Publikováno v:
The Journal of Immunology. 196:118.2-118.2
Reactive oxygen species play a key role in mediating T cell autoreactivity in the development of autoimmune diseases including Type 1 diabetes (T1D). It was recently shown that redox regulation of cell surface thiol levels can influence T cell activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb82fa27420960dc73481392720999cb
https://doi.org/10.4049/jimmunol.196.supp.118.2
https://doi.org/10.4049/jimmunol.196.supp.118.2
Publikováno v:
The Journal of Immunology. 196:118.1-118.1
Viral infections are highly-suspected environmental triggers of autoimmune Type 1 diabetes (T1D), but the mechanism remains unclear. Many innate immune pro-inflammatory anti-viral factors, including IFN-α/β, TNF-α, CXCL10 and CCL5, are pathogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52539e0f3439561523c6984346331b24
https://doi.org/10.4049/jimmunol.196.supp.118.1
https://doi.org/10.4049/jimmunol.196.supp.118.1
Autor:
Hubert Ming Tse, Lindsey E. Padgett, Dana Pham-Hua, Bing Xue, Brian Anderson, Michael Zeiger, Veronika Kozlovskaya, Eugenia Kharlampieva
Publikováno v:
The Journal of Immunology. 196:140.26-140.26
Type 1 diabetes (T1D) is an autoimmune disease resulting in pancreatic b-cell lysis via reactive oxygen species (ROS), pro-inflammatory cytokines, and islet-infiltrating leukocytes. One promising treatment for T1D is islet transplantation, but its cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5432a9c1b9145a885d8745734317f6aa
https://doi.org/10.4049/jimmunol.196.supp.140.26
https://doi.org/10.4049/jimmunol.196.supp.140.26
Autor:
Lindsey E Padgett, Hubert Ming Tse
Publikováno v:
The Journal of Immunology. 196:202.19-202.19
Efficient T cell immune activation requires a synergistic interaction between innate immune-derived reactive oxygen species (ROS) and pro-inflammatory cytokines. Our laboratory previously demonstrated that in the absence of NADPH oxidase (NOX)-derive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38580356585e00fe42cfc402693d8108
https://doi.org/10.4049/jimmunol.196.supp.202.19
https://doi.org/10.4049/jimmunol.196.supp.202.19