Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Hubert M Tse"'
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 12, Iss 2 (2024)
Introduction Static incubation (static glucose-stimulated insulin secretion, sGSIS) is a measure of islet secretory function. The Stimulation Index (SI; insulin produced in high glucose/insulin produced in low glucose) is currently used as a product
Externí odkaz:
https://doaj.org/article/a2883b83a3bc46e59f5f9b2e828927f0
Autor:
Alexandra Martin, Gail J. Mick, Heather M. Choat, Alison A. Lunsford, Hubert M. Tse, Gerald G. McGwin, Kenneth L. McCormick
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Based on preclinical studies, gamma aminobutyric acid (GABA) and immunization for the enzyme that produces GABA glutamate decarboxylase (GAD) could be a potential therapy for type 1 diabetes. Here the authors report that in a placebo-controlled, doub
Externí odkaz:
https://doaj.org/article/bd187b568e574842b032370e414dbc17
Autor:
Jin-Yong Chung, Yongjie Ma, Dingguo Zhang, Hayden H. Bickerton, Eric Stokes, Sweta B. Patel, Hubert M. Tse, Joseph Feduska, Rob S. Welner, Ronadip R. Banerjee
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106439- (2023)
Summary: Pancreatic β-cell mass expands during pregnancy and regresses in the postpartum period in conjunction with dynamic metabolic demands on maternal glucose homeostasis. To understand transcriptional changes driving these adaptations in β-cell
Externí odkaz:
https://doaj.org/article/e462455c24ea41eba113a99958e8fbf9
Autor:
Guanlan Xu, Tiffany D. Grimes, Truman B. Grayson, Junqin Chen, Lance A. Thielen, Hubert M. Tse, Peng Li, Matt Kanke, Tai-Tu Lin, Athena A. Schepmoes, Adam C. Swensen, Vladislav A. Petyuk, Fernando Ovalle, Praveen Sethupathy, Wei-Jun Qian, Anath Shalev
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Oral verapamil lowers inflammatory markers and daily insulin needs in subjects with type 1 diabetes and helps preserve pancreatic beta cell function for at least two years. In this context, serum chromogranin A provides a promising therapy marker.
Externí odkaz:
https://doaj.org/article/4e4dbf4ca54f400292b98c7c54971be1
Autor:
Samuel I. Blum, Jared P. Taylor, Jessie M. Barra, Ashley R. Burg, Qiao Shang, Shihong Qiu, Oren Shechter, Aleah R. Hayes, Todd J. Green, Aron M. Geurts, Yi-Guang Chen, Hubert M. Tse
Publikováno v:
JCI Insight, Vol 8, Iss 2 (2023)
Type 1 diabetes (T1D) is an autoimmune disease resulting in pancreatic β cell destruction. Coxsackievirus B3 (CVB3) infection and melanoma differentiation-associated protein 5–dependent (MDA5-dependent) antiviral responses are linked with T1D deve
Externí odkaz:
https://doaj.org/article/481ea67a6fde4ec79a6074eb8b6ff38c
Autor:
Katie E. Heath, Joseph M. Feduska, Jared P. Taylor, Julie A. Houp, Davide Botta, Frances E. Lund, Gail J. Mick, Gerald McGwin, Kenneth L. McCormick, Hubert M. Tse
Publikováno v:
Biomedicines, Vol 11, Iss 7, p 1948 (2023)
Type 1 diabetes (T1D) is an autoimmune disease culminating in the destruction of insulin-producing pancreatic cells. There is a need for the development of novel antigen-specific strategies to delay cell destruction, including combinatorial strategie
Externí odkaz:
https://doaj.org/article/87fca8b0abb74ff7898353e973960d0c
Autor:
Kateryna Polishevska, Sandra Kelly, Purushothaman Kuppan, Karen L. Seeberger, Saloni Aggarwal, Joy Paramor, Larry D. Unsworth, Hubert M. Tse, Gregory S. Korbutt, Andrew R. Pepper
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1137 (2023)
Beta cell replacement therapies can restore glycemic control to select individuals living with type 1 diabetes. However, the obligation of lifelong immunosuppression restricts cell therapies from replacing exogenous insulin administration. Encapsulat
Externí odkaz:
https://doaj.org/article/66a636e3137441e39325b8f3f61481b3
Publikováno v:
JCI Insight, Vol 7, Iss 4 (2022)
Type 1 diabetes is an autoimmune disease characterized by insulin-producing β cell destruction. Although islet transplantation restores euglycemia and improves patient outcomes, an ideal transplant site remains elusive. Brown adipose tissue (BAT) ha
Externí odkaz:
https://doaj.org/article/ea8b52a79e0144b28ad1a60b19df5c50
Autor:
Jared P. Taylor, Hubert M. Tse
Publikováno v:
Redox Biology, Vol 48, Iss , Pp 102159- (2021)
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) are enzymes that generate superoxide or hydrogen peroxide from molecular oxygen utilizing NADPH as an electron donor. There are seven enzymes in the NOX family: NOX1-5 and dual oxidas
Externí odkaz:
https://doaj.org/article/baf255f7e1004065919d385061bb255b
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Type 1 diabetes (T1D) is an autoimmune disease characterized by autoreactive T cell-mediated destruction of insulin-producing pancreatic beta-cells. Loss of beta-cells leads to insulin insufficiency and hyperglycemia, with patients eventually requiri
Externí odkaz:
https://doaj.org/article/525f0d48bc1041999138423c092c223d