Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Hubert Fleury"'
Autor:
Hubert Fleury, Nicolas Malaquin, Véronique Tu, Sophie Gilbert, Aurélie Martinez, Marc-Alexandre Olivier, Skye Alexandre Sauriol, Laudine Communal, Kim Leclerc-Desaulniers, Euridice Carmona, Diane Provencher, Anne-Marie Mes-Masson, Francis Rodier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/ed50d1fb4e7042b095404c0fe115e55f
Autor:
David Allard, Isabelle Cousineau, Eric H Ma, Bertrand Allard, Yacine Bareche, Hubert Fleury, John Stagg
Publikováno v:
eLife, Vol 12 (2023)
CD73 is an ectonucleotidase overexpressed on tumor cells that suppresses anti-tumor immunity. Accordingly, several CD73 inhibitors are currently being evaluated in the clinic, including in large randomized clinical trials. Yet, the tumor cell-intrins
Externí odkaz:
https://doaj.org/article/54283ce127e14f698a4be600a42ce22d
Autor:
Maxime Cahuzac, Patricia Langlois, Benjamin Péant, Hubert Fleury, Anne-Marie Mes-Masson, Fred Saad
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Pre-activation of autophagy mediates resistance to olaparib by decreasing nuclear SQSTM1/p62, which increases homologous recombination-mediated repair through filamin A expression and BRCA1/Rad51 recruitment.
Externí odkaz:
https://doaj.org/article/90493fedb1da4a0c9ce515338e9d1823
Autor:
Caitlin T. Fierheller, Laure Guitton-Sert, Wejdan M. Alenezi, Timothée Revil, Kathleen K. Oros, Yuandi Gao, Karine Bedard, Suzanna L. Arcand, Corinne Serruya, Supriya Behl, Liliane Meunier, Hubert Fleury, Eleanor Fewings, Deepak N. Subramanian, Javad Nadaf, Jeffrey P. Bruce, Rachel Bell, Diane Provencher, William D. Foulkes, Zaki El Haffaf, Anne-Marie Mes-Masson, Jacek Majewski, Trevor J. Pugh, Marc Tischkowitz, Paul A. James, Ian G. Campbell, Celia M. T. Greenwood, Jiannis Ragoussis, Jean-Yves Masson, Patricia N. Tonin
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-26 (2021)
Abstract Background Familial ovarian cancer (OC) cases not harbouring pathogenic variants in either of the BRCA1 and BRCA2 OC-predisposing genes, which function in homologous recombination (HR) of DNA, could involve pathogenic variants in other DNA r
Externí odkaz:
https://doaj.org/article/52b67832911d434ca9c1266c56a3622d
Autor:
Melica Nourmoussavi Brodeur, Kayla Simeone, Kim Leclerc-Deslauniers, Hubert Fleury, Euridice Carmona, Diane M. Provencher, Anne-Marie Mes-Masson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. Among the key challenges in developing effective therapeutics is the poor translation of preclinical models used in the drug discovery pipeline. This leaves drug attrit
Externí odkaz:
https://doaj.org/article/8cf5cb2dcdec424aabc6b0c6535c4a57
Autor:
Hubert Fleury, Nicolas Malaquin, Véronique Tu, Sophie Gilbert, Aurélie Martinez, Marc-Alexandre Olivier, Skye Alexandre Sauriol, Laudine Communal, Kim Leclerc-Desaulniers, Euridice Carmona, Diane Provencher, Anne-Marie Mes-Masson, Francis Rodier
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Abstract Senescence is a tumor suppression mechanism defined by stable proliferation arrest. Here we demonstrate that the known synthetic lethal interaction between poly(ADP-ribose) polymerase 1 inhibitors (PARPi) and DNA repair triggers p53-independ
Externí odkaz:
https://doaj.org/article/4e2c1618e64c4bbe831260ba6926f628
Autor:
Bishnubrata Patra, Muhammad Abdul Lateef, Melica Nourmoussavi Brodeur, Hubert Fleury, Euridice Carmona, Benjamin Péant, Diane Provencher, Anne-Marie Mes-Masson, Thomas Gervais
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0244549 (2020)
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy in North America, underscoring the need for the development of new therapeutic strategies for the management of this disease. Although many drugs are pre-clinically tested ever
Externí odkaz:
https://doaj.org/article/d266e6ed81b6455cb1b0cba6b5001e96
Autor:
Fred Saad, Anne-Marie Mes-Masson, Francis Rodier, Kim Leclerc-Desaulniers, Hubert Fleury, Véronique Tu, Nicolas Malaquin, Benjamin Péant, Sophie Gilbert
Supplementary Data from Targeting IKKε in Androgen-Independent Prostate Cancer Causes Phenotypic Senescence and Genomic Instability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f81e82557729c541c2a2cfd0ba61e6b
https://doi.org/10.1158/1535-7163.22522387
https://doi.org/10.1158/1535-7163.22522387
Autor:
Fred Saad, Anne-Marie Mes-Masson, Francis Rodier, Kim Leclerc-Desaulniers, Hubert Fleury, Véronique Tu, Nicolas Malaquin, Benjamin Péant, Sophie Gilbert
Supplementary Figure from Targeting IKKε in Androgen-Independent Prostate Cancer Causes Phenotypic Senescence and Genomic Instability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842f6038bdf70d5ef37084f1666c49dc
https://doi.org/10.1158/1535-7163.22522384
https://doi.org/10.1158/1535-7163.22522384
Autor:
Fred Saad, Anne-Marie Mes-Masson, Francis Rodier, Kim Leclerc-Desaulniers, Hubert Fleury, Véronique Tu, Nicolas Malaquin, Benjamin Péant, Sophie Gilbert
Advanced prostate cancer will often progress to a lethal, castration-resistant state. We previously demonstrated that IKKε expression correlated with the aggressiveness of prostate cancer disease. Here, we address the potential of IKKε as a therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668860dbc5c5fe127a60d9848bdfde5c
https://doi.org/10.1158/1535-7163.c.6543358
https://doi.org/10.1158/1535-7163.c.6543358