Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Hubert Arokium"'
Autor:
Lilit Simonyan, Mathilde Gonin, James Hanks, Jordan Friedlein, Kevin Dutrec, Hubert Arokium, Akandé Rouchidane Eyitayo, Toukounou Megann Doudy, Stéphane Chaignepain, Stéphen Manon, Laurent Dejean
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
The S184 residue of Bax is the target of several protein kinases regulating cell fate, including AKT. It is well-established that, in cellulo, the substitution of S184 by a non-phosphorylatable residue stimulates both the mitochondrial localization o
Externí odkaz:
https://doaj.org/article/64d6b3d2d0bf4495bb4bb1c2dca1ceac
Autor:
Gajendra W. Suryawanshi, Hubert Arokium, Sanggu Kim, Wannisa Khamaikawin, Samantha Lin, Saki Shimizu, Koollawat Chupradit, YooJin Lee, Yiming Xie, Xin Guan, Vasantika Suryawanshi, Angela P. Presson, Dong-Sung An, Irvin S. Y. Chen
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-20 (2021)
Abstract Background Current understanding of hematopoiesis is largely derived from mouse models that are physiologically distant from humans. Humanized mice provide the most physiologically relevant small animal model to study human diseases, most no
Externí odkaz:
https://doaj.org/article/a33261ec0106441cb92fe0e423004265
Autor:
Wannisa Khamaikawin, Saki Shimizu, Masakazu Kamata, Ruth Cortado, Yujin Jung, Jennifer Lam, Jing Wen, Patrick Kim, Yiming Xie, Sanggu Kim, Hubert Arokium, Angela P. Presson, Irvin S.Y. Chen, Dong Sung An
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss , Pp 23-32 (2018)
Investigations of anti-HIV-1 human hematopoietic stem/progenitor cell (HSPC)-based gene therapy have been performed by HIV-1 challenge after the engraftment of gene-modified HSPCs in humanized mouse models. However, the clinical application of gene t
Externí odkaz:
https://doaj.org/article/836d21f4c4f245cbb6e241a7b6b951aa
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 4086 (2021)
BCL-2 family members are major regulators of apoptotic cell death in mammals. They form an intricate regulatory network that ultimately regulates the release of apoptogenic factors from mitochondria to the cytosol. The ectopic expression of mammalian
Externí odkaz:
https://doaj.org/article/a369c43e044c4d679c34efda486661f1
Autor:
Hubert Arokium, Masakazu Kamata, Sanggu Kim, Namshin Kim, Min Liang, Angela P Presson, Irvin S Chen
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e108682 (2014)
Long interspersed element-1 (LINE-1 or L1) retrotransposition induces insertional mutations that can result in diseases. It was recently shown that the copy number of L1 and other retroelements is stable in induced pluripotent stem cells (iPSCs). How
Externí odkaz:
https://doaj.org/article/1dae87dcc7c04802bda2e4f1357220b1
Autor:
Gene-Errol E Ringpis, Saki Shimizu, Hubert Arokium, Joanna Camba-Colón, Maria V Carroll, Ruth Cortado, Yiming Xie, Patrick Y Kim, Anna Sahakyan, Emily L Lowe, Munetoshi Narukawa, Fadi N Kandarian, Bryan P Burke, Geoff P Symonds, Dong Sung An, Irvin S Y Chen, Masakazu Kamata
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e53492 (2012)
Down-regulation of the HIV-1 coreceptor CCR5 holds significant potential for long-term protection against HIV-1 in patients. Using the humanized bone marrow/liver/thymus (hu-BLT) mouse model which allows investigation of human hematopoietic stem/prog
Externí odkaz:
https://doaj.org/article/2b0ee1ff496b470290d5a8ee5f6b119e
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2021, 22 (8), pp.4086. ⟨10.3390/ijms22084086⟩
International Journal of Molecular Sciences, Vol 22, Iss 4086, p 4086 (2021)
International Journal of Molecular Sciences, MDPI, 2021, 22 (8), pp.4086. ⟨10.3390/ijms22084086⟩
International Journal of Molecular Sciences, Vol 22, Iss 4086, p 4086 (2021)
International audience; BCL-2 family members are major regulators of apoptotic cell death in mammals. They form an intricate regulatory network that ultimately regulates the release of apoptogenic factors from mitochondria to the cytosol. The ectopic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6898f6d151b366a5233a58035a03ef5
https://hal.archives-ouvertes.fr/hal-03395265
https://hal.archives-ouvertes.fr/hal-03395265
Autor:
Vasantika Suryawanshi, Xin Guan, Samantha Lin, Wannisa Khamaikawin, Saki Shimizu, Hubert Arokium, Dong-Sung An, Angela P. Presson, Koollawat Chupradit, Yiming Xie, Irvin S. Y. Chen, Sanggu Kim, Gajendra W. Suryawanshi, YooJin Lee
Background: Current understanding of hematopoiesis is largely derived from mouse models that are physiologically distant from humans. Humanized mice provide the most physiologically relevant small animal model to study human diseases, most notably pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3b306102097188b67035bc758ee4b46
https://doi.org/10.1101/2020.08.21.261537
https://doi.org/10.1101/2020.08.21.261537
Autor:
Namshin Kim, Hyewon Choi, Yiming Xie, Jing Wen, Eugene Wang, Hubert Arokium, Gajendra W. Suryawanshi, Sanggu Kim, Chong Zhang, Irvin S. Y. Chen, Shihyoung Kim, Dong-Sung An, Wannisa Khamaikawin, Hannah Yu, Saki Shimizu, Angela P. Presson
Publikováno v:
Science Advances
A novel approach enables a direct comparison of anti-HIV– and non–gene-modified stem-cell engraftment in an HIV-1–infected host.
Despite advances in hematopoietic stem/progenitor cell (HSPC) transplant for HIV-1–infected patients, the im
Despite advances in hematopoietic stem/progenitor cell (HSPC) transplant for HIV-1–infected patients, the im
Autor:
Jennifer Lam, Ruth Cortado, Yiming Xie, Angela P. Presson, Yujin Jung, Masakazu Kamata, Hubert Arokium, Irvin S. Y. Chen, Wannisa Khamaikawin, Patrick Y. Kim, Dong Sung An, Sanggu Kim, Jing Wen, Saki Shimizu
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss, Pp 23-32 (2018)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Investigations of anti-HIV-1 human hematopoietic stem/progenitor cell (HSPC)-based gene therapy have been performed by HIV-1 challenge after the engraftment of gene-modified HSPCs in humanized mouse models. However, the clinical application of gene t