Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Hubert Thole"'
Publikováno v:
FEBS Open Bio, Vol 11, Iss 4, Pp 1084-1092 (2021)
P‐glycoprotein (Pgp) detoxifies cells by exporting hundreds of chemically dissimilar hydrophobic and amphipathic compounds and is implicated in multidrug resistance (MDR) in the treatment of cancers. Photoaffinity labeling of plasma membrane vesicl
Externí odkaz:
https://doaj.org/article/c2b81dd83c9042d1b7692f7ae5d4f30b
Autor:
Gabriele Möller, Bettina Husen, Dorota Kowalik, Leena Hirvelä, Dariusz Plewczynski, Leszek Rychlewski, Josef Messinger, Hubert Thole, Jerzy Adamski
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e10969 (2010)
Steroid-related cancers can be treated by inhibitors of steroid metabolism. In searching for new inhibitors of human 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD 1) for the treatment of breast cancer or endometriosis, novel substances based
Externí odkaz:
https://doaj.org/article/06b4b6d915cf4e4aa8a692666c9b6054
Autor:
Jerzy Adamski, Katja Vouk, Pieter Houba, Martina Ribič-Pucelj, Jasna Šinkovec, Tina Šmuc, Christina Guggenberger, Bettina Husen, Hubert Thole, Claudia Thaete, Tea Lanišnik Rižner
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 125:231-242
In the search for novel biomarkers of endometriosis, we selected 152 genes from the GeneLogic database based on results of genome-wide expression analysis of ovarian endometriosis, plus 20 genes related to estrogen metabolism and action. We then perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9de66b8b116ded5ae9ede11d9ed1798
https://doi.org/10.1016/j.jsbmb.2011.03.010
https://doi.org/10.1016/j.jsbmb.2011.03.010
Autor:
Josef Messinger, Ulrich L. Günther, Christian Ludwig, Jerzy Adamski, Maria J.P. van Dongen, Hubert Thole, Gabriele Möller, Michel Stephan, Christina Fischer, Paul J. A. Michiels
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 117:93-98
The enzyme 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) has become an important drug target for breast cancer because it catalyzes the interconversion of estrone to the biologically more potent estradiol which also plays a crucial role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0553528e6084b6351d8f4e7c61e707b5
https://doi.org/10.1016/j.jsbmb.2009.07.004
https://doi.org/10.1016/j.jsbmb.2009.07.004
Autor:
Sabine Fechner, Elke Winterhager, Markus Schmidt, Ruth Grümmer, Bettina Husen, Hubert Thole, Rainer Kimmig, Isabella Gashaw
Publikováno v:
Fertility and Sterility. 88:1029-1038
Objective To investigate the regulation of estrogen-converting enzymes in human ectopic endometrial tissue. Design Animal study. Setting Academic medical center. Animal(s) Sixty female nude mice with implanted human endometrial tissue. Patient(s) Twe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e4800c0eb3afbb75b27dbd6c3736b99
https://doi.org/10.1016/j.fertnstert.2006.11.153
https://doi.org/10.1016/j.fertnstert.2006.11.153
Publikováno v:
Molecular and Cellular Endocrinology. 248:109-113
17Beta-hydroxysteroid dehydrogenase (17HSD1) is an enzyme activating estrone (E1) to estradiol (E2). In the present study, a mechanistic animal model was set up for evaluating putative inhibitors for the human enzyme in vivo. Estrogen-dependent MCF-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b214968ecc73f57a824a5e85aa510c95
https://doi.org/10.1016/j.mce.2005.11.042
https://doi.org/10.1016/j.mce.2005.11.042
Autor:
Hubert Thole, Ashok Konda, Uwe Schön, Monika Buchholz, Uwe Reinecker, M. S. Prabhu, Josef Messinger
Publikováno v:
Tetrahedron Letters. 46:7111-7115
An efficient Pd(0)-catalyzed protocol for the rapid and efficient preparation of 3-aminoestrone via 3-benzylaminoestrone from estrone–triflate is described. The three step synthesis proceeds with an overall yield of about 55% using X-Phos as optima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43b0f5666e5f2db5896bde16c41e4443
https://doi.org/10.1016/j.tetlet.2005.08.105
https://doi.org/10.1016/j.tetlet.2005.08.105
Autor:
Regine Kraft, Anja Krippner-Heidenreich, Bernhard Lüscher, Myra M. Hurt, Gesa Walsemann, Maroun J. Beyrouthy, Robert V. Talanian, Hubert Thole, Stefanie Speckgens
Publikováno v:
Molecular and Cellular Biology. 25:3704-3714
The transcriptional regulator Yin Yang 1 (YY1) controls many aspects of cell behavior and is essential for development. We analyzed the fate of YY1 during apoptosis and studied the functional consequences. We observed that this factor is rapidly tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcc1321988c1b86feaa00f80fc5526e
https://doi.org/10.1128/mcb.25.9.3704-3714.2005
https://doi.org/10.1128/mcb.25.9.3704-3714.2005
Autor:
Ursula Teichmann, Rudolf Leiser, Hubert Thole, Christina Wirth, Bernd Hoffmann, Klaus Failing, Gerhard Schuler
Publikováno v:
Biology of Reproduction. 66:976-982
The bovine placenta produces estrogens from the first trimester until the end of its life span. However, with the exception of the immediate prepartal and intrapartal phases, in which an involvement of placental estrogens has been suggested for the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd81bb3fab7dd32d732592ebbb171cd2
https://doi.org/10.1095/biolreprod66.4.976
https://doi.org/10.1095/biolreprod66.4.976
Publikováno v:
European Journal of Biochemistry. 269:1278-1286
Previous biochemical studies have indicated that the membrane-bound thyrotropin-releasing hormone (TRH)-degrading enzyme (TRH-DE) from brain and liver and the serum TRH-DE are derived from the same gene. These studies also suggested that the serum en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66b0c07b04a983bf840429903b274a06
https://doi.org/10.1046/j.1432-1033.2002.02768.x
https://doi.org/10.1046/j.1432-1033.2002.02768.x