Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Hubert, Truebel"'
Autor:
Jack W. Scannell, James Bosley, John A. Hickman, Gerard R. Dawson, Hubert Truebel, Guilherme S. Ferreira, Duncan Richards, J. Mark Treherne
Publikováno v:
Nature Reviews Drug Discovery. 21:915-931
Successful drug discovery is like finding oases of safety and efficacy in chemical and biological deserts. Screens in disease models, and other decision tools used in drug research and development (R&D), point towards oases when they score therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::215d03ac920c1d2ff8a18551f3f01f94
https://doi.org/10.1038/s41573-022-00552-x
https://doi.org/10.1038/s41573-022-00552-x
Publikováno v:
Research in Social and Administrative Pharmacy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7998ae3157a2496d109631192ad314a5
https://doi.org/10.1016/j.sapharm.2023.05.007
https://doi.org/10.1016/j.sapharm.2023.05.007
Publikováno v:
Drug Discovery Today. 27:1326-1331
Although 'unmet medical need' (UMN) is an increasingly used term in the healthcare sector instrumental to the approximate value of drug discovery projects relevant to portfolio management, no standardized approach exists for its quantification. Espec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df604633f340bec92eba1ec73ce36fca
https://doi.org/10.1016/j.drudis.2021.12.019
https://doi.org/10.1016/j.drudis.2021.12.019
Autor:
Hubert Truebel, Mark Seidler
Publikováno v:
Nature reviews. Drug discovery. 21(12)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98260f3e40170fb818cac754a3b3f0a
https://pubmed.ncbi.nlm.nih.gov/36167985
https://pubmed.ncbi.nlm.nih.gov/36167985
Autor:
Alexander Schmidt, Jakob Balitzki, Ljubica Grmaca, Julia Vogel, Philip Boehme, Katharina Boden, Jörg Hüser, Hubert Truebel, Thomas Mondritzki
Publikováno v:
Heart failure reviews.
Innovations in the development of novel heart failure therapies are essential to further increase the predictive value of early research findings. Animal models are still playing a pivotal role in ‘translational research’. In recent years, the tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f34e130583f707a8f62a46dca9fe74f2
https://pubmed.ncbi.nlm.nih.gov/36001250
https://pubmed.ncbi.nlm.nih.gov/36001250
Autor:
Thomas Thurston, Hubert Truebel
Publikováno v:
Drug Discovery Today. 25:2089-2094
In drug development, a crucial step is the transition of a company from preclinical stages to human trials: the so-called 'Valley-of-Death' (VoD) that most efforts do not survive. Here, we analyzed how the valuations of biotech companies in the life
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d841413efbfd2399a76793b023663aa3
https://doi.org/10.1016/j.drudis.2020.09.033
https://doi.org/10.1016/j.drudis.2020.09.033
Autor:
Asif Rahman, Joseph J. Frassica, Hubert Truebel, Philip Boehme, Yale Chang, K. Jansson, E. Schwager, Minnan Xu-Wilson, Gregory Boverman, Brian David Gross, S. Schiffer
Publikováno v:
npj Digital Medicine, Vol 4, Iss 1, Pp 1-9 (2021)
Heterogeneous patient populations, complex pharmacology and low recruitment rates in the Intensive Care Unit (ICU) have led to the failure of many clinical trials. Recently, machine learning (ML) emerged as a new technology to process and identify bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2527be65a6c933fe827243a05bf5001
https://doi.org/10.1038/s41746-021-00505-5
https://doi.org/10.1038/s41746-021-00505-5
Autor:
Mira Pavkovic, Jörg Hüser, Martina Delbeck, Pierre Wasnaire, Anja Buchmüller, Wilfried Dinh, Thomas Mondritzki, Elisabeth Pook, Hanna Tinel, Axel Kretschmer, Carsten Schmeck, Hubert Truebel, Peter Kolkhof
Publikováno v:
Journal of Cardiovascular Pharmacology. 74:44-52
Increased plasma vasopressin levels have been shown to be associated with the progression of congestive heart failure. Vasopressin mediates water retention by renal tubular V2 receptor activation as well as vasoconstriction, cardiac hypertrophy, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ba46fb465addea10690793d97c93fe
https://doi.org/10.1097/fjc.0000000000000677
https://doi.org/10.1097/fjc.0000000000000677
Autor:
Sven Schmiedl, Philip Boehme, Thomas Ostermann, Hubert Truebel, Thorsten Langer, P. A. Thuermann, H. Doll, Dirk Cysarz, Jacek Szymanski, Sandra Wuester
Publikováno v:
European Journal of Applied Physiology. 119:1253-1260
Helium in oxygen (HELIOX) can relieve airway obstruction and lower the work of breathing because it increases the threshold at which turbulent gas flow is induced. Less turbulent and more laminar flow lowers the work of breathing. According to guidel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c7aa06698546047c8ec7a89b2a48af5
https://doi.org/10.1007/s00421-019-04116-7
https://doi.org/10.1007/s00421-019-04116-7
Autor:
Axel Kuck, Kristian Kinscher, Leonard Fehring, Helmut Hildebrandt, Johannes Doerner, Jonas Lange, Hubert Truebel, Philip Boehme, Celina Bade, Thomas Mondritzki
Publikováno v:
International Journal of Environmental Research and Public Health; Volume 19; Issue 14; Pages: 8466
Background: Value-Based Care (VBC) is being discussed to provide better outcomes to patients, with an aim to reimburse healthcare providers (HCPs) based on the quality of care they deliver. Little is known about German HCPs’ knowledge of VBC. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5531becf67701f4dd355b37ff6c9af0
https://doi.org/10.3390/ijerph19148466
https://doi.org/10.3390/ijerph19148466