Zobrazeno 1 - 10
of 206
pro vyhledávání: '"Hubert, Schorle"'
Autor:
Ondrej Sanovec, Michaela Frolikova, Veronika Kraus, Jana Vondrakova, Maryam Qasemi, Daniela Spevakova, Ondrej Simonik, Lindsay Moritz, Drew Lewis Caswell, Frantisek Liska, Lukas Ded, Jiri Cerny, Tomer Avidor-Reiss, Saher Sue Hammoud, Hubert Schorle, Pavla Postlerova, Klaus Steger, Katerina Komrskova
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
There is a well-established link between abnormal sperm chromatin states and poor motility, however, how these two processes are interdependent is unknown. Here, we identified a possible mechanistic insight by showing that Protamine 2, a nuclear DNA
Externí odkaz:
https://doaj.org/article/01217af291054fa2bce783d7e7012b4f
Autor:
Simon Schneider, Andjela Kovacevic, Michelle Mayer, Ann-Kristin Dicke, Lena Arévalo, Sophie A Koser, Jan N Hansen, Samuel Young, Christoph Brenker, Sabine Kliesch, Dagmar Wachten, Gregor Kirfel, Timo Strünker, Frank Tüttelmann, Hubert Schorle
Publikováno v:
eLife, Vol 12 (2023)
Cylicins are testis-specific proteins, which are exclusively expressed during spermiogenesis. In mice and humans, two Cylicins, the gonosomal X-linked Cylicin 1 (Cylc1/CYLC1) and the autosomal Cylicin 2 (Cylc2/CYLC2) genes, have been identified. Cyli
Externí odkaz:
https://doaj.org/article/d7b2c5f7a719474eb70622b7f2bb0821
Autor:
Clara Agudo-Rios, Amber Rogers, Isaiah King, Virali Bhagat, Le My Tu Nguyen, Carlos Córdova-Fletes, Diego Krapf, Jerome F. Strauss, Lena Arévalo, Gina Esther Merges, Hubert Schorle, Eduardo R. S. Roldan, Maria Eugenia Teves
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Protamines (PRM1 and PRM2) are small, arginine-rich, nuclear proteins that replace histones in the final stages of spermiogenesis, ensuring chromatin compaction and nuclear remodeling. Defects in protamination lead to increased DNA fragmentation and
Externí odkaz:
https://doaj.org/article/0b3dc1b728e94eb9a72c3ca60a98d04f
Autor:
Rebekka Vogtmann, Alina Riedel, Ivanka Sassmannshausen, Sarah Langer, Elisabeth Kühnel-Terjung, Rainer Kimmig, Hubert Schorle, Elke Winterhager, Alexandra Gellhaus
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2040 (2024)
Preeclampsia (PE) is characterized by maternal hypertension and placental dysfunction, often leading to fetal growth restriction (FGR). It is associated with an overexpression of the anti-angiogenic sFLT1 protein, which originates from the placenta a
Externí odkaz:
https://doaj.org/article/15793ccb024f49a39659f3441f4cc120
Autor:
Margaretha A. Skowron, Teresa K. Becker, Lukas Kurz, Sina Jostes, Felix Bremmer, Florian Fronhoffs, Kai Funke, Gamal A. Wakileh, Melanie R. Müller, Aaron Burmeister, Thomas Lenz, Anja Stefanski, Kai Stühler, Patrick Petzsch, Karl Köhrer, Peter Altevogt, Peter Albers, Glen Kristiansen, Hubert Schorle, Daniel Nettersheim
Publikováno v:
Molecular Oncology, Vol 16, Iss 4, Pp 982-1008 (2022)
Testicular germ cell tumors (GCTs) are stratified into seminomas and nonseminomas. Seminomas share many histological and molecular features with primordial germ cells, whereas the nonseminoma stem cell population—embryonal carcinoma (EC)—is pluri
Externí odkaz:
https://doaj.org/article/8b019692a23e4a8fbca36ce693337779
Autor:
Jan Langkabel, Arik Horne, Lorenzo Bonaguro, Lisa Holsten, Tatiana Hesse, Alexej Knaus, Yannick Riedel, Matthias Becker, Kristian Händler, Tarek Elmzzahi, Kevin Bassler, Nico Reusch, Leon Harootoonovtch Yeghiazarian, Tal Pecht, Adem Saglam, Thomas Ulas, Anna C. Aschenbrenner, Franziska Kaiser, Caroline Kubaczka, Joachim L. Schultze, Hubert Schorle
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Synthetic embryo models have arisen as an approach to probe early development in vitro, facilitating the study of difficult to access stages. Here the authors present a simple system for generating embryo-like structures that resemble peri-implantati
Externí odkaz:
https://doaj.org/article/4777dcfcfbcb4d98ae83f5dc3f98bef3
Autor:
Cornelia Fink, Nelli Baal, Jochen Wilhelm, Poonam Sarode, Roswitha Weigel, Valérie Schumacher, Daniel Nettersheim, Hubert Schorle, Carmen Schröck, Martin Bergmann, Sabine Kliesch, Monika Kressin, Rajkumar Savai
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 7, Pp 731-742 (2021)
Germ cell neoplasia in situ (GCNIS) is the noninvasive precursor of testicular germ cell tumors type II, the most common cancer in young men, which originates from embryonic germ cells blocked in their maturation. GCNIS is associated with impaired Se
Externí odkaz:
https://doaj.org/article/2eeffefdcd874ae3b7d3662678c9baf0
Autor:
Lena Arévalo, Gina Esther Merges, Simon Schneider, Franka Enow Oben, Isabelle Sophie Neumann, Hubert Schorle
Publikováno v:
PLoS Genetics, Vol 18, Iss 6, p e1010272 (2022)
Protamines are unique sperm-specific proteins that package and protect paternal chromatin until fertilization. A subset of mammalian species expresses two protamines (PRM1 and PRM2), while in others PRM1 is sufficient for sperm chromatin packaging. A
Externí odkaz:
https://doaj.org/article/9d9d940ce4144d3aa33873d55a80fea3
Autor:
Julia Armbruster, Mostafa A. Aboouf, Max Gassmann, Angela Egert, Hubert Schorle, Veit Hornung, Tobias Schmidt, Jonathan L. Schmid-Burgk, Glen Kristiansen, Anne Bicker, Thomas Hankeln, Hao Zhu, Thomas A. Gorr
Publikováno v:
PLoS ONE, Vol 17, Iss 10 (2022)
Myoglobin (MB) is known to bind and deliver oxygen in striated muscles at high expression levels. MB is also expressed at much reduced levels in mammary epithelial cells, where the protein´s function is unclear. In this study, we aim to determine wh
Externí odkaz:
https://doaj.org/article/034667929e304d02929e2820f85604a6
Autor:
Naila Umer, Lena Arévalo, Sharang Phadke, Keerthika Lohanadan, Gregor Kirfel, Dominik Sons, Denise Sofia, Walter Witke, Hubert Schorle
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Profilins (PFNs) are key regulatory proteins for the actin polymerization in cells and are encoded in mouse and humans by four Pfn genes. PFNs are involved in cell mobility, cell growth, neurogenesis, and metastasis of tumor cells. The testes-specifi
Externí odkaz:
https://doaj.org/article/d5215482101f4e63ab46d98bc0bfa201