Zobrazeno 1 - 10
of 1 767
pro vyhledávání: '"Hubert, Scharnagl"'
Autor:
Faisal Aziz, Norbert J. Tripolt, Peter N. Pferschy, Hubert Scharnagl, Mahmoud Abdellatif, Abderrahim Oulhaj, Martin Benedikt, Ewald Kolesnik, Dirk von Lewinski, Harald Sourij
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-10 (2024)
Abstract Background Sodium-glucose co-transporter 2 inhibitors (SGLT2i) have been suggested to exert cardioprotective effects in patients with heart failure, possibly by improving the metabolism of ketone bodies in the myocardium. Methods This post h
Externí odkaz:
https://doaj.org/article/07ffd372f2ab42df9425a10e0e586e5c
Autor:
Janne Pott, Azin Kheirkhah, Jesper R. Gadin, Marcus E. Kleber, Graciela E. Delgado, Holger Kirsten, Lukas Forer, Stefanie M. Hauck, Ralph Burkhardt, Hubert Scharnagl, Markus Loeffler, Winfried März, Joachim Thiery, Christian Gieger, Annette Peters, Angela Silveira, Ferdinand van’t Hooft, Florian Kronenberg, Markus Scholz
Publikováno v:
Biology of Sex Differences, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key player of lipid metabolism with higher plasma levels in women throughout their life. Statin treatment affects PCSK9 levels also showing evidence of sex-differential ef
Externí odkaz:
https://doaj.org/article/52974b7065a44f87b840e07239a4601b
Autor:
Iva Klobučar, Hansjörg Habisch, Lucija Klobučar, Matias Trbušić, Gudrun Pregartner, Andrea Berghold, Gerhard M. Kostner, Hubert Scharnagl, Tobias Madl, Saša Frank, Vesna Degoricija
Publikováno v:
Biomedicines, Vol 12, Iss 9, p 1972 (2024)
The strong associations between the serum levels of adiponectin and the lipoprotein subclasses observed in healthy subjects are much weaker in patients with metabolic syndrome (MS). However, the impact of sex on these associations remained unexplored
Externí odkaz:
https://doaj.org/article/ccf406e0d3b24884ba034b297089c133
Autor:
Iva Klobučar, Hansjörg Habisch, Lucija Klobučar, Matias Trbušić, Gudrun Pregartner, Andrea Berghold, Gerhard M. Kostner, Hubert Scharnagl, Tobias Madl, Saša Frank, Vesna Degoricija
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 5050 (2024)
Metabolic syndrome (MS) is a widespread disease in developed countries, accompanied, among others, by decreased adiponectin serum levels and perturbed lipoprotein metabolism. The associations between the serum levels of adiponectin and lipoproteins h
Externí odkaz:
https://doaj.org/article/38463837651e4fa48f0eb6cf13f06752
Autor:
Claudia D. Fuchs, Natalie Sroda, Hubert Scharnagl, Ruchi Gupta, Wesley Minto, Tatjana Stojakovic, John T. Liles, Grant Budas, David Hollenback, Michael Trauner
Publikováno v:
JHEP Reports, Vol 5, Iss 11, Pp 100874- (2023)
Background & Aims: The nuclear receptor farnesoid X receptor (FXR) is a key regulator of hepatic bile acid (BA) and lipid metabolism, inflammation and fibrosis. Here, we aimed to explore the potential of cilofexor (GS-9674), a non-steroidal FXR agoni
Externí odkaz:
https://doaj.org/article/98d4075a323d4c7285415bf45d052aaa
Autor:
Claudia D. Fuchs, Thierry Claudel, Veronika Mlitz, Alessandra Riva, Moritz Menz, Ksenia Brusilovskaya, Felix Haller, Maximilian Baumgartner, Philipp Königshofer, Lukas W. Unger, Wilhelm Sjöland, Hubert Scharnagl, Tatjana Stojakovic, Georg Busslinger, Thomas Reiberger, Hanns-Ulrich Marschall, Michael Trauner
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 5, Pp 847-856 (2023)
Background & Aims: Glucagon-like peptide (GLP)-2 may exert antifibrotic effects on hepatic stellate cells (HSCs). Thus, we aimed to test whether application of the GLP-2 analogue teduglutide has hepatoprotective and antifibrotic effects in the Mdr2/A
Externí odkaz:
https://doaj.org/article/38608f1e5ab54160be285257cf74e3a7
Autor:
Claudia D. Fuchs, Emmanuel D. Dixon, Tim Hendrikx, Veronika Mlitz, Annika Wahlström, Marcus Ståhlman, Hubert Scharnagl, Tatjana Stojakovic, Christoph J. Binder, Hanns‐Ulrich Marschall, Michael Trauner
Publikováno v:
Hepatology Communications, Vol 6, Iss 9, Pp 2368-2378 (2022)
Abstract Bile salt export pump (Bsep) (Abcb11)−/− mice are protected from acquired cholestatic injury due to metabolic preconditioning with a hydrophilic bile acid (BA) pool with formation of tetrahydroxylated bile acids (THBAs). We aimed to expl
Externí odkaz:
https://doaj.org/article/2eb49cbe92514bb2bf2ca7d245d3ffe7
Autor:
Angela P. Moissl, Stefan Lorkowski, Andreas Meinitzer, Stefan Pilz, Hubert Scharnagl, Graciela E. Delgado, Marcus E. Kleber, Bernhard K. Krämer, Burkert Pieske, Martin R. Grübler, Helmut Brussee, Dirk von Lewinski, Hermann Toplak, Astrid Fahrleitner-Pammer, Winfried März, Andreas Tomaschitz
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106459- (2023)
Summary: Branched-chain amino acids (BCAAs) are effectors of metabolic diseases, but their impact on mortality is largely unknown. We investigated the association of BCAA with risk factors and mortality in 2,236 participants of the Ludwigshafen Risk
Externí odkaz:
https://doaj.org/article/6a953afe75424800a553f68d656a16ca
Autor:
Caren Sourij, Faisal Aziz, Sarah Krappinger, Andreas Praschk, Thomas Metzner, Harald Kojzar, Andreas Zirlik, Tatjana Stojakovic, Dieter Pätzold, Dirk von Lewinski, Robert Zweiker, Hubert Scharnagl, Harald Sourij
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15531 (2023)
Lipoprotein(a) (Lp(a)) is considered an independent risk factor for cardiovascular diseases. The plasma concentration of Lp(a) is largely genetically determined but varies over a wide range within the population. This study investigated changes in Lp
Externí odkaz:
https://doaj.org/article/b4282282ea764b8e97f4436150e6481b
Autor:
Michael Holzer, Senka Ljubojevic-Holzer, Douglas Ricardo Souza Junior, Julia T. Stadler, Alankrita Rani, Hubert Scharnagl, Graziella Eliza Ronsein, Gunther Marsche
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 12, Pp 100307- (2022)
The HDL proteome has been widely recognized as an important mediator of HDL function. While a variety of HDL isolation methods exist, their impact on the HDL proteome and its associated function remain largely unknown. Here, we compared three of the
Externí odkaz:
https://doaj.org/article/78bccfc9dd0f4d298a32e31e5fd85ad2