The lipooligosaccharide of the gut symbiont Akkermansia muciniphila exhibits a remarkable structure and TLR signaling capacity

Autor: Pilar Garcia-Vello, Hanne L. P. Tytgat, Janneke Elzinga, Matthias Van Hul, Hubert Plovier, Marta Tiemblo-Martin, Patrice D. Cani, Simone Nicolardi, Marco Fragai, Cristina De Castro, Flaviana Di Lorenzo, Alba Silipo, Antonio Molinaro, Willem M. de Vos

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Abstract The cell-envelope of Gram-negative bacteria contains endotoxic lipopolysaccharides (LPS) that are recognized by the innate immune system via Toll-Like Receptors (TLRs). The intestinal mucosal symbiont Akkermansia muciniphila is known to conf

Externí odkaz: https://doaj.org/article/f6dae89e0f5e4f84b676e2c79896f6ea

Erythritol Availability in Bovine, Murine and Human Models Highlights a Potential Role for the Host Aldose Reductase during Brucella Infection

Autor: Thibault Barbier, Arnaud Machelart, Amaia Zúñiga-Ripa, Hubert Plovier, Charlotte Hougardy, Elodie Lobet, Kevin Willemart, Eric Muraille, Xavier De Bolle, Emile Van Schaftingen, Ignacio Moriyón, Jean-Jacques Letesson

Publikováno v: Frontiers in Microbiology, Vol 8 (2017)

Erythritol is the preferential carbon source for most brucellae, a group of facultative intracellular bacteria that cause a worldwide zoonosis. Since this polyol is abundant in genital organs of ruminants and swine, it is widely accepted that erythri

Externí odkaz: https://doaj.org/article/575807365bd94234a9acf1ac1f3de78e

Convergent evolution of zoonotic Brucella species toward the selective use of the pentose phosphate pathway

Autor: Ignacio Moriyón, Amaia Zúñiga-Ripa, Thibault Godard, Hubert Plovier, Xavier De Bolle, Thibault Barbier, Kevin Willemart, Emile Van Schaftingen, Jean-Jacques Letesson, Arnaud Machelart, Christoph Wittmann

Publikováno v: Machelart, A, Willemart, K, Zúñiga-Ripa, A, Godard, T, Plovier, H, Wittmann, C, Moriyón, I, De Bolle, X, Van Schaftingen, E, Letesson, J-J & Barbier, T 2020, ' Convergent evolution of zoonotic Brucella species toward the selective use of the pentose phosphate pathway ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 42, pp. 26374-26381 . https://doi.org/10.1073/pnas.2008939117

Mechanistic understanding of the factors that govern host tropism remains incompletely understood for most pathogens. Brucella species, which are capable of infecting a wide range of hosts, offer a useful avenue to address this question. We hypothesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4d0123a63e1eff20756f8437ccd5a5
https://pure.unamur.be/ws/files/52044708/Machelart_et_al_2020.pdf

Pasteurized Akkermansia muciniphila protects from fat mass gain but not from bone loss

Autor: Julia M. Scheffler, Hubert Plovier, Patrice D. Cani, Ulrika Islander, Lina Lawenius, Willem M. de Vos, Klara Sjögren, Petra Henning, Karin H Nilsson, Hannah Colldén, Claes Ohlsson, Karin Gustafsson

Publikováno v: American Journal of Physiology. Endocrinology and Metabolism, 318(4), E480-E491
American Journal of Physiology. Endocrinology and Metabolism 318 (2020) 4
American Journal of Physiology-Endocrinology and Metabolism, Vol. 318, no.4, p. E480-E491 (2020)

Probiotic bacteria can protect from ovariectomy (ovx)-induced bone loss in mice. Akkermansia muciniphila is considered to have probiotic potential due to its beneficial effect on obesity and insulin resistance. The purpose of the present study was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e8a16eb42bc2a5bd189924162e54169
http://hdl.handle.net/10138/326336

Pasteurized

Autor: Lina, Lawenius, Julia M, Scheffler, Karin L, Gustafsson, Petra, Henning, Karin H, Nilsson, Hannah, Colldén, Ulrika, Islander, Hubert, Plovier, Patrice D, Cani, Willem M, de Vos, Claes, Ohlsson, Klara, Sjögren

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism

Probiotic bacteria can protect from ovariectomy (ovx)-induced bone loss in mice. Akkermansia muciniphila is considered to have probiotic potential due to its beneficial effect on obesity and insulin resistance. The purpose of the present study was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ceee4a83c10927cfa8c8f74ba2905fe8
https://pubmed.ncbi.nlm.nih.gov/31961709